Dissecting regulatory syntax in human development with scalable multiomics and deep learning Transcription factors (TFs) establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility, and regulating gene expre...

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️

Thanks to labs of Eric Wagner, Vik khurana and Ashleigh Schaffer for the awesome collaboration that made this work possible! #RNA #StressResponse #RNA #GeneReg #stemcells #Genomics #RNAsky #GeneRegulation #TEsky #AcademicSky
Check out the paper here: authors.elsevier.com/c/1kwzmL7PXu...

Excited to be at @keystonesymposia.bsky.social for first time ! Looking forward to plenty of science&fun at #Epigenetics in #Development and Disease #KSEpigenetics25 keysym.us/KSEpigenetics25 #RNA #GeneReg #RNAsky #GeneRegulation

CpxR regulates yccA and ldtC as an activator and efeU as a repressor despite binding in a similar relative position on these promoters.

How does a TFs function depend on the promoter it regulates? We know that a TF can have different effects on different promoters. For example, consider this case: CpxR regulates ldtCp, yccAp, efeUp at a similar location. Yet two of them are activated, one repressed #GeneReg 🧪 tinyurl.com/3hr9njnd

My PhD supervisor Gabriele Schweikert will be presenting two of my projects here! Please check it out 🧬🖥️

#DevBio #GeneReg

(Bicentenary) Integration of multi-modal datasets to understand the adipose tissue response to obesity at The University of Manchester on FindAPhD.com PhD Project - (Bicentenary) Integration of multi-modal datasets to understand the adipose tissue response to obesity at The University of Manchester, listed on FindAPhD.com

Our project: advanced data science x discovery research

What can we learn about adipose tissue behaviour in obesity from the ever-increasing number of 'omics datasets? (🚶‍♀️ and 🐀) What hypotheses can we then test in vivo?

Details here: tinyurl.com/353a8n9r
Closes: 10th Jan

🧪💻🧬 #AcademicSky #GeneReg

Next, if you're looking for your daily hit of posts that focus on gene regulation, here's a relevant feed:
bsky.app/profile/shau...

The way the feed works is that it searches for posts containing #GeneReg or a set of keywords (see next post).

I'll be heading for the first time to #PAG31 in a few days. Want to talk #lncRNAs, #genereg, #evolution? Hit me up!

Also, any PAG tips/hacks I should know about?

See you in San Diego!

🪴🦊🧬

I'll be heading for the first time to #PAG31 in a few days. Want to talk #lncRNAs, #genereg, #evolution? Hit me up!

Also, any PAG tips/hacks I should know about?

See you all in San Diego!

🪴🦊🧬