I’m looking for an automated way to read others’s scientific data without giving credit or acknowledgement, and also claim full credit for insights from it. And I want it to have a fitting name

OAI: say no more

There's also a kind of intentional myopia in focusing just on higher ed when diagnosing "declining trust." Only one of these explanations also has something to say about why there's simultaneously declining trust in elections, public health authorities, etc, in the same spaces over the same period

I'm excited to tell you about the most recent preprint in my lab, demonstrating that a conserved spindle matrix protein, NPP-21/TPR, is required for the stronger checkpoint in germline cells during embryogenesis in C. elegans

Diffusive spreading across dynamic mitochondrial network architectures | PNAS In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...

Congrats to Keaton, Cam, Lena, and all coauthors! 6/6
www.pnas.org/doi/10.1073/...

By analyzing mito dynamics across a variety of human cell lines, Lewis lab PhD candidate Cam found how cells can access both regimes, highlighting how mitochondrial dynamics actively tune intracellular transport!! 🚀 5/

Plot of steady-state network content vs decay time across several mitochondrial connectivity regimes.

As mito network connectivity increases, transport shifts from 3D spreading between clusters (“social”) to lower-dimensional diffusion within continuous networks (“physical”).

📊 This provides a unifying way to think about mitochondrial organization in the context of cell geometry! 4/

Segmented mitochondria from 3 different types of cells, with sub-networks highlighted in bright colors.

In this work, Keaton from the Kolover lab shows that spreading of molecules like proteins, RNA, lipids, and ions depends on key timescales ⏱️: how often mitochondria meet, fuse, and divide. 3/

Mitochondria aren’t static; they form dynamic networks that constantly fuse, divide, and move. 🔄

Depending on the conditions, they can behave like a tightly connected “physical network” or a loose “social network” of transient interactions. 2/

Diffusive spreading across dynamic mitochondrial network architectures | PNAS In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...

Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/
www.pnas.org/doi/10.1073/...

where did you order these?

I had a wonderful time connecting with the research community at the Buck last week! Special thanks to Saam Doroodian, Malene Hansen, and Ashley Webb!

NIGMS is signed onto the F31 NOFO. grants.nih.gov/grants/guide...

MitoTracker transfers from astrocytes to neurons independently of mitochondria The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

Some molecular machines, like ribosomes, can persist for long periods of time in cells.

Could molecular aging of ribosomes shape how proteins are made?

In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)

www.biorxiv.org/content/10.6...

On my way to DC and looking forward to this exciting mini-symposium! #ASBMB26

Megan Doty et al discovered that myelin remains for weeks after cortical axons degenerate. We call the sheaths without an axon de-axoned myelin. During the slow, asynchronous, degeneration, microglia don't play a major role in clearing the axon or de-axoned myelin. www.science.org/doi/10.1126/...

Organelle-Targeted Laurdans Measure Heterogeneity in Subcellular Membranes and Their Responses to Saturated Lipid Stress - PubMed Organelles feature characteristic lipid compositions that lead to differences in membrane properties. In cells, membrane ordering and fluidity are commonly measured using the solvatochromic dye Laurdan, whose fluorescence is sensitive to lipid packing. As a general lipophilic dye, Laurdan stains all …

seen this? pubmed.ncbi.nlm.nih.gov/39069657/

Yes
bsky.app/profile/biot...

No Kings includes Draft Kings

We are organizing a mini-symposium on "Membrane and Organelle Dynamics" at ASBMB 2026! #ASBMB @asbmb.bsky.social
@aydinlab.bsky.social and I have put together a fantastic lineup of speakers for Day 1 morning. Come learn about some cutting-edge research in the field.

Thank you, Lorena! Happy to see this online 😁 🎉

Self-renewal of neuronal mitochondria through asymmetric division - preLights Neurons contain “hotspots” for mitochondrial biogenesis at distal branch points

Check out my first @prelights.bsky.social article, based on some great work done by Dr. Tejashree Waingankar & @samlewis.bsky.social at UC Berkeley 🔬🧬🧠

prelights.biologists.com/highlights/s...

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵

Preprint here!:
www.biorxiv.org/content/10.6...

@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid

Thank you!

@focalplane.bsky.social I recommend www.biorxiv.org/content/10.6...

I'm reading this now based on your recommendation, and it feels like listening to Bjork for the first time

I found me!

A lot of the time I would inject to guide them, as in "the authors chose to measure X to address their hypothesis; could they have measured something else instead? if they had measured Y, would that be a more direct test of their model or less direct, in your opinion?" etc, etc