Friends, I have written you a book on forensic metascience.
It is free. You can have it. Happy St. Valentine's Day.
If you wish to give me a gift back, you can use it to cause trouble - the greatest gift of all.
open.substack.com/pub/jamescla...
How does ageing impact type I and type II myofibre properties in human muscle? Oscar Horwath, Marcus Moberg, Sebastian Edman, @willapro.bsky.social (The Swedish School of Sport and Health Sciences) and Andrew Philp (@centenaryinstitute.bsky.social) investigate.
📜https://buff.ly/40tFBJG
New book "Explanation in Biology" with Cambridge University Press is out & open access!
Covers (1) causal explanation & (2) non-causal/mathematical explanation in life sciences--bio, neuro, etc 🌿🧬🧠
Introduction to philosophical work on scientific explanation!
www.cambridge.org/core/element...
Chair Stop-Motion 🪑💨 Made with 444 pictures taken over 10 days
Just a reminder that SMART goals are not as empirically sound as you might think they are (at least for physical activity and exercise).
Full article: The (over)use of SMART goals for physical activity promotion: A narrative review and critique www.tandfonline.com/doi/full/10....
The field of "ultra-processed" food research & its media coverage are littered with poor definitions & comparisons, w misleading conclusions. This creates an illusion that UPFs provide new insights, but it's all slight-of-hand. @mbolotnikova.bsky.social takes a deep dive www.vox.com/future-perfe...
Aw man, it started happening to me last year!?
Charles Piller’s new book ‘Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s’ will come out in February. A fantastic read about those who discover science fraud and the lack of response by institutions and publishers.
www.publishersweekly.com/9781668031247
I met her on holiday!?!?
Mines a photo I staged in my living room to make it look like I’m speaking at a conference.
Drinking Guinness in *England* before it was cool! 😎
Title slide: Will your code run again? Tips for making code reproducible in R
If you missed my talk but still want to learn how to make your R code more reproducible, my slides are here 🙂:
daxkellie.quarto.pub/will-your-co...
All the links to packages and resources I mentioned are there, so hopefully this can be a nice reference, too!
#ESAus2024 #rstats #quartopub 🧪🌏
Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice | #MyoBlue
pubmed.ncbi.nlm.nih.gov/39641290/
From Stanley & Spence (2024): https://journals.sagepub.com/doi/full/10.1177/25152459241285885. "Myth 1: There is a 95% chance your true score is in your interval Some authors correctly understand that the Standard Error of Measurement can be used to construct a confidence interval for a specific individual’s true score. This type of interval is an SEM-Single-Test-Taker Interval. Unfortunately, however, sometimes these authors then go on to misinterpret the information provided by the confidence interval. For example, Kaplan and Saccuzzo (2013)"
Myth 1: Re-iterating this point over and over again improves psychologists' understanding of statistics in a practically relevant manner.
A figure from https://onlinelibrary.wiley.com/doi/10.1111/sms.14490 showing percentage error for simulated VO2 and VCO2 in 15 different metabolic carts across ranges of 1000-4000 mL/min. The error between carts ranges from -25 to +25%, with most devices clustered around ±10% "FIGURE 4 Relative percentage error for V̇O 2 (top) and V̇CO 2 (bottom), as a function of the simulated V̇O 2 and V̇CO 2 for each device. Errors are averaged over each step of the “Std” (i.e., RER = 1.00) and “CPX” (i.e., RER increases with increased V̇O 2 ) protocols. Because the simulated V̇CO 2 differed between the “Std” and “CPX” protocols, the average simulated value is depicted on the x-axis in the figure. MC, mixing chamber; RER, respiratory exchange ratio; V̇CO 2 , rate of carbon dioxide production; V̇O 2 , rate of oxygen uptake."
Bas van Hooren et al recently published a comprehensive review of metabolic equipment
With rigorous calibration & operation, and taking out all possible biological variation with *simulated* gas exchange, the error between carts is still ±10+%
onlinelibrary.wiley.com/doi/10.1111/...
Title slide: Acting as if our research might matter - Analyzing data Image: A meteor about to strike the earth.
Clinical Researchers:
I am here to warn you about a meteor hurling towards us.
That meteor represents increasing scrutiny of clinical research; and in particular how we approach data collection, analysis, interpretation and reporting.
Prepare now, or face the consequences.
1/
You keep doing you, we’ll just have to catch up! 😅
James, you know I’m a huge fan of yours! So I say this with great respect! Speak clearly in plain language!
Yes, I’m religious. I believe in the holy trinity.
@katebolam.bsky.social welcome Kate!!!!
And I broke Joao Pedro.
@jesperfchristensen.bsky.social welcome to Blue Sky!!!!
So look. I've given about 20 talks where I highlight clinical research waste, and I now always ask the audience if they recognize that figure below. The answer is *always* the same - overwhelmingly No. If *you* recognize it, because you are here and informed, you must help spread the word. Please.
Comprehensive and timely new review on muscle regeneration impairment by diabetes www.sciencedirect.com/science/arti... of note: interesting angle on the synergy between intrinsic and extrinsic detriments of diabetes on muscle stem cells @myoblue.bsky.social
Played in Dublin the other week didn’t they?
✨ PREPRINT 📖🤩
"Study Preregistration: A How-To Guide"
Written for students, this guide outlines the 'what, why, and how' of preregistration, perceived barriers and their solutions, and 10 top tips to adopting and/or critically evaluating this open research practice.
osf.io/preprints/ps...
Some said it couldn’t be done. That it was impossible; ridiculous; absurd. But @tomchivers.bsky.social and I have done it: recorded a whole podcast episode about collider bias. www.thestudiesshowpod.com/p/episode-57...
Ultra-Runners: Help researchers understand more about NSAID use in racing and perhaps find a viable (safer) alternative. #running #ultramarathon
He’s finally out?
Just enough Indie and Rock bands to get me there! 😂
