Frontiers | γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids Cervical cancer is a leading cause of death among women globally, primarily driven by high-risk papillomaviruses. However, the effectiveness of chemotherapy ...

At our latest lab journal club, with Angélque Cayer, we discussed PMC10711208: a study showing γδ T cells preferentially kill HPV-transformed and cancer cervical organoids, linked to DNA-damage pathways & BTN3A1/BTN2A1.
#γδTcells
#CancerImmunology
#HPV
#Organoids
www.frontiersin.org/journals/imm...

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

More than an association. Looks like it’s through EBNA2!
By @shady-myounis.bsky.social et al., @stanforddeptmed.bsky.social.
www.science.org/doi/10.1126/...

Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient - Nature Communications Immune checkpoint blockade cancer therapy has been designed to enable tumor killing by conventional αβ T cells. Here authors show that in a Merkel cell carcinoma patient showing complete response to a...

At yesterday’s lab journal club, with
@yeganeh-almasi.bsky.social, we discussed PMC10848161: A case study showing γδ T cells driving lasting anti-tumor immunity during PD-1 blockade in Merkel cell carcinoma.
@natcomms.nature.com
#Immunotherapy #γδTcells
www.nature.com/articles/s41...

Novel trispecific killer engager targeting B7-H3 enhances natural killer cell antitumor activity against head and neck cancer Background Patients with head and neck squamous cell carcinoma (HNSCC), particularly the human papillomavirus negative (HPV −) subset, have a dismal prognosis. Furthermore, patients with Fanconi anemi...

At today’s lab journal club, we discussed PMC12306285: a trispecific killer engager targeting B7-H3 that boosts NK cell activity against head & neck cancer, even under hypoxia.
#Immunotherapy #NKcells
#CancerResearch #ImmunoSky
jitc.bmj.com/content/13/7...

My lab (1st photo), together with the Djaoud lab (2nd photo) took a little break from the lab to enjoy the stunning fall colors and crisp air at Gatineau Park. It was a refreshing gathering, full of connection and shared appreciation for each other, celebrating the accomplishments this past semester

Thank you, Payal. It was really nice to finally meet you in person! 🙂

Thank you, Monika! It was lovely to meet you.

We had an amazing γδ T Cell Conference with @yeganeh-almasi.bsky.social, @marileel.bsky.social & the incredible #gdTcells community, @forum-gd.bsky.social. Yeganeh & Marilee presented their work on KIR-enriched polyclonal γδ T cells in cancer immunotherapy. See you all in Wrocław in two years!

The program for the 11th International γδ T Cell Conference is now live!

Visit www.gammadeltatoronto.ca and register before the early bird deadline (Jan 13).

#gdTcells #gd2025 #BestConferenceEver

CMV elicits an expansion of CD16+CD8+ innate-like T cells, including αβ and γδ T cells, in utero.
@jclinical-invest.bsky.social
www.jci.org/articles/vie...