I am thrilled to share our article, out in
@pnas.org. Exceptional work from @malaymondal.bsky.social, who demonstrated that our redox-sensitive designer biomolecular condensates efficiently deliver a wide array of molecular cargo to HeLa cells.
www.pnas.org/doi/abs/10.1...

The organizing committee: Vijay Rangachari bsky.app/profile/rang..., Anant Paravastu, Ayanjeet Ghosh, and Ayyalusamy Ramamoorthy.

We have an incredible lineup of speakers this year, highlighted by the Keynote by Jennifer Lee, NHLBI. We want to thank our sponsors: The University of Southern Mississippi, bsky.app/profile/uofa..., Alabama; bsky.app/profile/gtre...; and Photothermal Spectroscopy Corp.

We are excited to launch the SouthEast Amyloid CONdensate (SEACON) symposium!! Our inaugural meeting will take place in Ocean Springs, MS, in August 2025. For details, please visit:

www.rangacharilab.com/1st-seacon-s...

Nice work, Samrat!

Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and nucleic acids that have emerged as important players in many cellular functions. Uncovering the sequence determinants of...

@malaymondal.bsky.social led an exceptional work supported by collaboration with the Clemons, Bai, and Huang labs.
This is a follow-up from our previous work on disulfide bond cross-linked condensates: pubs.acs.org/doi/10.1021/...

Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo. Biomolecular condensates (BCs) are phase-separated viscoelastic hubs within demixed solutions enriched in proteins and nucleic acids. Such condensates, also called membraneless organelles, are increas...

Excited to share our new data on the use of redox-sensitive peptide condensates as cell delivery vehicles. We show that our peptide condensates can efficiently deliver a variety of small molecules, DNA, mRNA, and proteins, to the cellular cytoplasm.
www.biorxiv.org/content/10.1....

Excited to share our latest work on amyloid-synthetic polymer blends. pubs.acs.org/doi/10.1021/...

nuts..

Want to know about #IDPs? Why not hear from @rohitpappu68.bsky.social in his typical éloquence royale?

Oh am sure every $ spent on $750b military is legit… saving $12b by killing science and bright minds is worth it..
grants.nih.gov/grants/guide...

Congrats, Alex!

Wishing you all a peaceful, healthy, and a prosperous 2025!!

It was fantastic and humbling to receive a personal email from @J_A_C_S, the editor-in-chief, congratulating us on this work. Malay_Moldal and others deserve all the credit.👏

see related conference: nationalmaglab.org/news-events/...

NEW SOCIETY ALERT! "International Society for Proteinopathies" is a group focused on pathomechanisms of protein-misfolding diseases. If you are interested in protein aggregation and phase transitions, this is for you.
Please come on board with us..
www.proteinopathies.org

Stereochemistry in the disorder–order continuum of protein interactions - Nature Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

A significant discovery elegantly demonstrated...
www.nature.com/articles/s41...

Structural polymorphism in amyloids—states within proteins’ solid-state Proteins are functionally diverse molecules that exist in a plethora of conformations and structures or as disordered ensembles, depending on their pr…

Check out our chapter on "Amyloid Polymorphism" in the book "The Three Functional States of Proteins."
www.sciencedirect.com/science/arti...

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Report: Every dollar of NIH research funding doubles in economic returns Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an

www.fiercebiotech.com/research/rep...

Biomolecular condensate starter pack!

Trying to compile & to bring together biomolecular condensate enthusiasts & critics!

Please join this non-exhaustive (sorry!) collection & just ping me for addition.

#condensates, #phaseseparation, #granules, #IDPs

go.bsky.app/NFqmffa

BONUS! If IDPs are your jam, check out an ever-expanding starter pack!
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Stunning..

A quintessential morning in southern India...

You have good students who care about you... enjoy, and happy birthday :)

Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and nucleic acids that have emerged as important players in many cellular functions. Uncovering the sequence determinants of...

Sharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...

When the tweets are gone, it's time to ❌ the X and flutter to the Bluesky 🦋...