Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo

www.biorxiv.org/content/10.6...

Can enzymes be made to self-destruct for therapeutic purposes?

“Reaction-hijacking of enzymes to generate potent therapeutic modulators in situ”. Very pleased that our Review is part of the 50th anniversary special edition of Trends in Biochemical Science.

doi.org/10.1016/j.ti...

IRB Barcelona invites applications for Group Leader positions in Chemical Biology (one) and Structural Biology (one) as part of its strategic effort to strengthen molecular sciences. The successful candidates will join a highly multidisciplinary and collaborative institute with strong expertise in cancer and metastasis, ageing and cell reprogramming, metabolism, cell differentiation, signal transduction, and gene expression, working at the interface of structural and computational biology, chemistry, and biology. IRB Barcelona is embedded in a vibrant scientific ecosystem and maintains close collaborations with major research infrastructures such as the Barcelona Supercomputing Center (BSC) and the ALBA Synchrotron, as well as leading research centres, universities, and hospitals in Barcelona. About IRB Barcelona IRB Barcelona (www.irbbarcelona.org) is a multidisciplinary research institute where scientists collaborate to address fundamental biomedical questions and unmet medical needs. The Institute currently hosts more than 500 members from around the world across 27 research groups. How to apply Applications should include a CV, letter of intent, brief (2-page) research proposal, and the names and contact details of at least three referees. Applications must be submitted via https://recruitment.irbbarcelona.org no later than 22 May 2026, quoting reference GL/26/01 (Chemical Biology) or GL/26/02 (Structural Biology). The successful candidates are expected to join in Q4 2026 or 2027, with flexibility depending on individual circumstances. For Informal enquiries, please contact the chair of the Search Committee (Prof. Xavier Salvatella, at xavier.salvatella@irbbarcelona.org) and for details and updates on the selection process please contact the Head of People at (irbglcall@irbbarcelona.org)

Was just asked to spread the word about this position.
Structural biology and Chemical Biology positions in Barcelona, one of the great cities of the world!
www.irbbarcelona.org/sites/defaul...

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...

Thrilled to share a new collaborative preprint, joint with Sean Prigge @johnshopkinssph.bsky.social, on the apicoplast ACP in #malaria parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @parasitesrule.org www.biorxiv.org/content/10.6...

Congrats Ahmad!! 🥂🍾

Our paper on the structural and functional basis of the human dimeric OS9–SEL1L–HRD1 ERAD complex, together with @qilabuva.bsky.social, is now out! Huge congratulations to Leo, Emir, and Elina!
www.nature.com/articles/s41...

Subcellular Structures in Native Hippocampal Synapses Revealed by Cryo-electron Tomography pubmed.ncbi.nlm.nih.gov/41491937/ #cryoEM

🔬 Our first community-contributed image is here!
Stunning SEMs of two Trichomonas vaginalis parasites connected by cytonemes.
Want to share your parasite images? Visit parasitesrule.com to contribute!
📸 Salas et al., eLife 2023 doi:10.7554/eLife.86067 @eLife

A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...

Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...

Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

😍 Zhou Lab on fire!!! 🔥🔥🔥 #cryoet #teamtomo

IsoNet2 determines cellular structures at submolecular resolution without averaging www.biorxiv.org/content/10.64898/2025.12...

Ribosomal Architecture and rRNA Modification Landscape in the Tick-Borne Parasite Babesia divergens pubmed.ncbi.nlm.nih.gov/41293005/ #cryoEM

ZAK activation at the collided ribosome - Nature The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫

www.nature.com/articles/s41...

A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social

Mechanism of Ribosome Stalling by the AMD1 C-terminal Tail Arrest Peptide www.biorxiv.org/content/10.1101/2025.11....

Structural basis of herpesvirus helicase-primase inhibition by pritelivir and amenamevir Structural studies of HSV-1 helicase-primase revealed how pritelivir and amenamevir bind and block its helicase activity.

New work from Tahirov x Lim collaboration! @qixianghe.bsky.social from my lab contributed the cryo-EM structures for this work. We are excited to help explain how anti-HSV drugs work and to guide their future development.
www.science.org/doi/10.1126/...
@unmc.bsky.social @uwbiochem.bsky.social

Seeing is believing-Plasmodium falciparum translation in action pubmed.ncbi.nlm.nih.gov/41202797/ #cryoEM

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

Congrats Paul!! Excited to see this out! 🥳

Chemical propulsion of hemozoin crystal motion in malaria parasites | PNAS Malaria parasites infect red blood cells where they digest host hemoglobin and release free heme inside a lysosome-like organelle called the food v...

Thrilled our study on heme crystal motion in #malaria @parasitesrule.org is now published @pnas.org, support from NIH, @bwfund.bsky.social, @uofutahcihd.bsky.social, UofU 3i. With Fu and Bidone labs @price.utah.edu, @uofubiochem.bsky.social, @uofuhealth.bsky.social
www.pnas.org/doi/10.1073/...

Congrats Misha, looks gorgeous! 🥳Can't wait to dig in 😍

Cryo-EM structure of the naked mole-rat ribosome reveals a stabilized split 28S rRNA The naked mole-rat (Heterocephalus glaber) is a long-lived mammal with remarkable resistance to cancer and hypoxia, suggesting the evolution of robust proteostasis networks. The ribosome, the central ...

We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity.

Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look.
www.biorxiv.org/content/10.1...

Endogenous structure of antimalarial target PfATP4 reveals an apicomplexan-specific P-type ATPase modulator Nature Communications - Here, the authors present the 3.7 Å cryoEM structure of native sodium efflux pump PfATP4 from Plasmodium falciparum, revealing a bound protein that they term...

Learn how our hunt for the native structure of top antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms.nature.com 👉 rdcu.be/eLRlH 🦠🔬❄️

A team effort led by @mehsehret.bsky.social & Anurag Shukla @akhilvaidya.bsky.social! #cryoEM #malaria

When noncanonical olfaction is optimal | PNAS The early olfactory system is canonically described by a “one-receptor-to-one-neuron” model: each olfactory sensory neuron (OSN) expresses a single...

It was so fun to work on this with @gkocker.bsky.social and @clienkaemper.bsky.social! It is out @pnas.org
If you love olfaction and love math, this one is for you!
🦟👃🧮

When noncanonical olfaction is optimal | PNAS www.pnas.org/doi/10.1073/...

Congrats, Halil and Team! 🥳

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 - Nature Communications This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome.
www.nature.com/articles/s41...