The spectrum of bipolar disorder in older adults Neuropsychopharmacology - The spectrum of bipolar disorder in older adults

This recent review highlights how late-life bipolar disorder is marked by disproportionate cognitive impairment & medical comorbidity that drive functional decline, underscoring the need for age-adjusted clinical strategies 🧠

Neurobiologists Hack Brain Circuits Tied to Placebo Pain Relief Scientists have identified the brain circuits tied to placebo pain relief. Researchers have known that placebo effects can be a powerful treatment, yet the underlying neurological mechanisms have not ...

Excited to share our new study on how the brain generates placebo pain relief!

We developed a mouse model that recapitulates key features of human placebo analgesia, then used it to identify causal circuitry.

www.sciencedirect.com/science/arti...

today.ucsd.edu/story/neurob...

1/n

Nominate your work for this brilliant award for

✨✨preclinical null findings✨✨

www.ecnp.eu/awards/list-...

SubcellulaRVis: a web-based tool to simplify and visualise subcellular compartment enrichment

shiny.its.manchester.ac.uk/subcellularv...

Simply copy/paste your gene/protein list

#NucAcidsRes 2022
academic.oup.com/nar/article/...

Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice | Nature Neuroscience Alzheimer’s disease has widespread effects on brain structure, function and behavior, but we lack a systematic dissection of its impact across hundreds of forebrain and brainstem regions. Here, using diffusion tensor MRI at 25 µm, we mapped the global consequences of mutations in APP and PSEN1 across 231 regions of interest (ROIs) in male and female 5×FAD BXD hybrid mice at 14 months. Over half of the ROIs change in volume along rostrocaudal and mediolateral axes of the CNS, with unexpected swelling in the neocortex, hippocampus and amygdala of up to 10%, counterbalanced by shrinkage in the thalamus, brainstem and most white matter tracts. Yet, total brain volume is unaltered. Variation in individual ROI volumes is highest in females. Differences in fear acquisition and contextual memory performance covary with volumes of several regions and can have opposite polarities between cases and controls. These structural benchmarks establish a foundation for testing therapeutic interventions

Alzheimer's mutations in APP/PSEN1 alter over 50% of 231 brain regions in 5×FAD BXD mice. Detailed MRI maps reveal vast changes at 25μm. PMID:41748785, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-025-02199-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

📢🔔The 39th IMGC starts today!! Amidst blowing snow 🌨️ & northern lights 🌌 in Reykjavik, IMGS members have gathered to share the latest advances in #genetics, #genomes, and #diseasemodeling in mammalian systems 🧬🧪

See the abstract booklet here ➡️ www.imgs.org/program-39th...

#IMGS #IMGC2026

Professor Philippa Borrill

We are devastated to announce that our colleague and friend Professor Philippa Borrill died over the Easter weekend following a rare immune system disorder (HLH). She was a fantastic scientist, collaborator and mentor, and a close friend to many: www.jic.ac.uk/news/profess...

Genetics reveal why people respond differently to GLP-1 weight-loss drugs Genetic variants in GLP1R and GIPR, which encode targets of GLP-1-based medications, offer insights into why responses to these drugs vary and who might face adverse effects.

Why do people respond differently to GLP-1 weight-loss drugs? Genetics has the answer - provided in this genome wide association study led by @adamauton.bsky.social www.nature.com/articles/s41...
🧪

www.nature.com/articles/d41...

If you’re using 10x Genomics (Flex v1) for scRNA-seq, this study is a must-read. 🧪

It uncovers a key artefact:
• Probe barcodes themselves introduce bias
• Some barcodes systematically alter gene expression signals
• Apparent DEGs may be technical, not biological

www.biorxiv.org/content/10.6...

A short episode of social interaction reduces reinstatement of cocaine seeking after abstinence

This effect depends on a competition between functionally specialized dopaminergic ensembles within the VTA

www.nature.com/articles/s41...

Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

🥁🎉The Psychosis Collective proudly presents our first preprint

𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞

𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴

starring Le He & Harriet Feldman

www.biorxiv.org/content/10.6...

We wanted to understand how antipsychotics work. Thread🧵

I am looking for short papers using phylogenetic trees to test alternative hypotheses regarding evolution that can easily be grasped by undergraduate students in biochemistry. Please RT and share your ideas.

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Photo of a cuneiform tablet shown from the front, back, and various side angles. At the bottom is a watermark for the Yale Babylonian Collection, and to the left of that watermark is a 1cm scale. Based on the scale, the tablet is about 4-5cm wide and 3-4cm tall. In the bottom left corner of the image is a tiny winged creature thumbnail, and along the left side are the letters and numbers "GCBC 766 (YPM BC 034383)"

Today, I've been reading a very old medical commentary from ancient Uruk, written in the Akkadian language.

It's a tiny cuneiform tablet that explains words and phrases excerpted from another text - a diagnostic manual, known in antiquity as Sa-gig.

The Candida Genome Database’s new website is now live! Everything has been entirely rewritten from scratch! A quarter of a century old Perl code (some of which I wrote!) producing HTML 2.0 (😬) is all gone, with modern python in its place, producing modern webpages with JavaScript and CSS to make

AI shifts much of the challenge into testing, verification, generalisation, and on-going assessment. Which I have no doubt will be *AI enabled* code bases/systems themselves.

Me & @aysuo.bsky.social are hiring a postdoc to study gene–environment interplay in health & social inequalities 🧬

You'll analyze genomic data as part of a collaboration with Uppsala & Oslo at @amsterdamumc.bsky.social (NL)

werkenbij.amsterdamumc.org/en/vacatures...

Please RT for karma points ♥️

Spontaneous behavior is a succession of self-directed tasks Weinreb et al. reveal a hierarchy of timescales in mouse behavior, including low-level syllables and high-level behavioral states. States and syllables are encoded in different brain areas. Prefrontal...

Have you ever wondered why mice do what they do when they are free to do whatever they want? Check out our latest (and this slightly delayed thread about our recent paper, led by Caleb Weinreb and friends...) www.cell.com/neuron/fullt...

Final version is out now!

karger.com/bbe/article-...

3 new fellowships 👇🏼

We are now recruiting for new philanthropically funded fellowships in Brain Health and Multimorbidity at the University of Edinburgh, in INCR and @edinunineuro.bsky.social 🎉

There are two non-clinical posts and one clinical elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Please repost!

Matt Ridley gave the inaugural "NIH Scientific Freedom Lecture Series" earlier today and I just wanted to run through some of the main claims he made - you'll be unsurprised to learn that almost all of them are false.

Here's his summary slide - let's start there.

🧵👇

1:08 - This data from @davidashbrook.bsky.social, Robert W. Williams, and G. Allan Johnson shows Thioflavin S, which is used to stain amyloid plaques in #Alzheimers research, in a whole mouse brain. Check out their latest publication here: www.nature.com/articles/s41...

To mark the close of #BrainAwarenessWeek, we have a jam-packed roundup of 3D brain data from our #neuroscience community, spanning research areas from Alzheimer’s to psychedelics. Read on to learn more about the brains in this video! 📖

#FluorescenceFriday

🚨 Our lab is hiring postdoctoral fellows in two different areas of research: (1) mitochondrial biology and (2) reproductive science. Postings are below, and you can visit bombawarczaklab.com to learn more about what we do!

Repro: apply.interfolio.com/183045
Mito: apply.interfolio.com/183230

The effects of housing temperature on mouse physiology and implications for disease modeling - Lab Animal This Review summarizes the evidence that housing temperature affects mouse physiology and disease models, highlighting thermoneutral housing as a practical way to improve the reproducibility and trans...

www.nature.com/articles/s41...

New review out! Housing temperature—an important focus of my PhD—shapes mouse physiology and disease modelling. We discuss how it can influence pharmacological outcomes via body mass and energy expenditure.

I thought we were already keeping our mice warm, but this article suggests we need to keep increasing that temp!

Exciting news! The @yorkpsychology.bsky.social are recruiting 3 new ART (research and teaching) lecturers! One role will be prioritised for cognitive, affective and/or social neuroscience.

#neuroskyence #cognition #psychscisky #neurojobs

In London for the Functional Genomics in Mental Health workshop to talk about #genetic #preclinical models for #neuropsychiatric disorders, #brain and behavioural development, and the work we are doing within the #MURIDAE cluster of the @mrcmousenetwork.bsky.social

#MHPFGx 🧠🧬🐭📊