Excited to share our structural insights into how microtubules differentially guide phosphorylation of kinetochore-microtubule regulators, Ndc80 and MCAK, for chromosome segregation. Heroic efforts by Yiming Niu with a fun collaboration with Jennifer DeLuca lab!
www.science.org/doi/10.1126/...
Congratulations! Looking forward to reading this
We finally managed to write Ikers master thesis project together. Interesting and careful work on FAM122A.
www.biorxiv.org/content/10.6...
www.sciencedirect.com/science/arti...
I have multiple positions available to join my lab from this summer: #postdoc, #student and #technician. Adverts to follow but see www.saurinlab.com for further details. #senescence, #mitosis, #cellcycle, #phosphorylation are the key areas. Email me if interested.
To kickstart this new Bluesky account: We're hiring!
The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab.
Details in the flyer — get in touch! 👇
Last days to apply this position in our group! Do join us in this great Institute @crg.eu, with great colleagues, and help shaping the science and culture of our lab!
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
Two new papers from the lab published in The EMBO Journal!
link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1
@ukri.org Could you please make a statement about whether this will impact on grants already in review from autumn 2025? It's hard to accept grant opportunities closing, but even harder to accept the rug being pulled after review. Rumours of a 1-5% acceptance rate would be incredibly hard to take
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
PhD position in my lab!
Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...
We are also recruiting a Postdoc in cell/molecular biology!
3yr, fully funded by @cancerresearchuk.org more details here: news.cancerresearchuk.org/2025/11/27/s...
Apply here: www.imperial.ac.uk/jobs/search-...
Group-based Prediction System (GPS) 6.0
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci.
Register to attend: tinyurl.com/PMCseminar2
Previous seminars: www.youtube.com/@PMCModularity
youtu.be/BFU1OCkhBwo?...
The best thing I’ve listened to all year. A brilliantly articulated vision about the dangers of AI which stresses the importance of societal pressure in demanding a safe future. Please consider listening and deciding for yourself if and how you can help
open.spotify.com/episode/1S8F...
2 recent preprints show the mitotic stopwatch monitors more than just mitotic delays - it protects against WGD, cell enlargement and other stresses that mildly activate p53. It may act to amplify p53 signals to suppress tumourigenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.6...
We’re recruiting a Postdoctoral Researcher at OIST (Okinawa, Japan) to explore how mitotic stress shapes aging.
If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you.
More info: www.oist.jp/careers/post...
Website: www.oist.jp/research/res...
I agree. And others offering ideas or help for work in progress would also be a step forward. We need to collaborate at the ideas stage much more and the internet could really help facilitate that.
Interesting. Looking forward to reading these…Congrats!
Last 3 days to apply for this post. Deadline 27/10/25
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Nice to see that out. Congrats!
The model is based on the fact that paclitaxel binds strongly to microtubules. It could also be relevant for other cancer drugs that bind strongly to abundant cellular targets, such as microtubules or DNA
Seeing a loved one roll the dice with drugs like this (as too many of us will) really hits home how little we know. That was the inspiration to get this idea out. We must learn how these drugs work if we are going to improve on them
A simple idea for how paclitaxel achieves tumour selectivity: It is better retained inside dense tissue, allowing tumour levels to stay high even after it has cleared the healthy cells. A model that requires testing, but could be used to improve treatments if correct
www.biorxiv.org/content/10.1...
