Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

"proteasome-derived defence peptides could provide an untapped source of natural antibiotics..." 🤯

www.nature.com/articles/s41...

Clams as biosensors of water quality 😄

Ensuring rigour of low-biomass microbiome research

www.nature.com/articles/s41...

Defense Against Dishonest Charts This is a guide to protect ourselves and to preserve what is good about turning data into visual things.

This excellent interactive tutorial on misleading data visualizations explores the idea of a "counter chart" — the graph you draw in response to refute a misleading claims

flowingdata.com/projects/dis...

an excellent resource for my upcoming synthetic biology lectures, thank you, very well timed! 😄

How to "program" living cells.🧫

In 2000, physicists (incl. Michael Elowitz) made bacteria blink on-and-off every 150 minutes. Their experiment, which blended mathematics and wet-lab methods, launched the field of synthetic biology.

Learn how they did it in my first interactive story!

My cats’ favourite thing is colourful tin foil. Breaks the bank, that one.

Out now! We consolidated >600 Dutch yeast and characterised their activity against spoilage yeasts and relevant human and plant pathogens, focusing on yeasts that secrete antifungal proteins. Great resource for biocontrol and beyond.
pubmed.ncbi.nlm.nih.gov/39875071/

Engineering a genomically recoded organism with one stop codon - Nature Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into pro...

Amazing work from Farren Isaacs team at Yale - reducing E.coli's genetic code down to only using a single stop codon. A 62 codon GRO with lots of potential for applications. www.nature.com/articles/s41...

Microbes Saving Lives and Reducing Suffering Click on the article title to read more.

#Microbes Saving Lives & Reducing Suffering—led by KenTimmis, this is a call to action for understanding and exploiting microbes & their role in helping humans at the face of current challenges as a global society @microbiotech.bsky.social
enviromicro-journals.onlinelibrary.wiley.com/doi/full/10....

Building orthogonal ribosome control for engineering biology at University of Leeds on FindAPhD.com PhD Project - Building orthogonal ribosome control for engineering biology at University of Leeds, listed on FindAPhD.com

2) Engineering novel methods for ribosome control
with @rna-julie.bsky.social
Deadline 14 March.
findaphd.com/phds/project...

Happy to chat to anyone interested ahead of the deadlines!

2/2

Building a fluorescent toolbox for exploring translation in Vibrio natriegens at University of Leeds on FindAPhD.com PhD Project - Building a fluorescent toolbox for exploring translation in Vibrio natriegens at University of Leeds, listed on FindAPhD.com

Two PhD positions available in my group:

1) Investigating ribosome biology in V.natriegens by single particle tracking
with @ryanfseipke.bsky.social @aleksponjavic.bsky.social
Deadline 28 February.
www.findaphd.com/phds/project...

1/2

Solid-State Nanopore Real-Time Assay for Monitoring Cas9 Endonuclease Reactivity The field of nanopore sensing is now moving beyond nucleic acid sequencing. An exciting avenue is the use of nanopore platforms for the monitoring of biochemical reactions. Biological nanopores have b...

We cannot join #SMPS4 but hot off the press our nanopore work to monitor CAS9 reactivity and its off-target effects. pubs.acs.org/doi/10.1021/...

👋👋 Hi everyone! The Astbury Centre is now on Bluesky. Follow along for updates about exciting Astbury Centre science. For now, we have put together a starter pack of members of the Astbury Centre community.

London SynBio Network 6 London SynBio afterwork talks and networking event on Thursday 12th of December

Join us Jan. 23, 17:45 for the first 2025 LSN event!
🧬 Designing de novo tRNAs for Genetic Code Expansion
Amir Guppy
🧪 Harnessing synbio tools for solving crucial biotech questions
Dr. Anastasiya Kishkevich

events.humanitix.com/copy-of-lond...

Happy New Year everyone. Just a reminder that there are 3 days left to apply for a BBSRC-funded PhD position with myself and Julie Aspden on ribosome synthetic biology!

Nominations for the 2025 Dorothy Bishop Award are now open!

Thoroughly enjoyed Next-Gen Synthetic Biology #NGSB24 in Ghent.

A special blend of incredible speakers and laid back forum to chat science.

Halfway home with a head buzzing with ideas and a lengthy reading list for next week.👩‍🔬📚

Thanks to the organisers! @vibtrainconf.bsky.social

really nice work! will definitely consider it for my introductory R class.

I'm writing up a brief history of the tidyverse? What do you want to know about it? #rstats

Currently advertising a fully funded PhD position open to UK and international students. Deadline 6 Jan 2025.

bsky.app/profile/ecsi...

Building orthogonal ribosome control for engineering biology at University of Leeds on FindAPhD.com PhD Project - Building orthogonal ribosome control for engineering biology at University of Leeds, listed on FindAPhD.com

Project is co-supervised Julie Aspden and part of Leeds' Astbury Centre.

Start date: Oct 2025. Deadline 6 Jan.

Link: www.findaphd.com/phds/project...

Looking for a PhD in molecular/synthetic biology?
Interested in RNA, protein synthesis or molecular machines?

Currently advertising a BBSRC-funded PhD position on engineering novel methods for ribosome control.

Details below. Please don't hesitate to get in touch if you'd like to know more.

Delighted to find, as a recent cat parent, that our cats are promising scientists. Here is Woody demonstrating that cats are non-Newtonian liquids… kind of.

He will write up his findings as soon as nap time is over. Maybe.

London SynBio Network 5 London SynBio afterwork talks and networking event on Thursday 12th of December

Join us Dec. 12, 17:45 for the final LSN event of 2024! 🧬

⏭️ Directed evolution of molecular chaperones towards aggregation-prone proteins
ComeStellio

🏥 Engaging cancer patients on their attitudes towards microbiome engineering
@kimberleyaowen.bsky.social

events.humanitix.com/london-synbi...

Gogec 2025 Team Registration Made with Tally, the simplest way to create forms.

Late registration for Gogec is now open till 21 Dec. Looking forward to seeing many of you (and your projects) there! Register at the link ⬇️

tally.so/r/wzzAX1

A red ribosome in front of a figure showing the phylogenetic relationships between organisms in GARNET with information on growth temperatures and ribosome sequences

📰 Hot off the press at @naturecomms.bsky.social:
RNA language models predict mutations that improve RNA function
www.nature.com/articles/s41...

Congrats to @kshulgina.bsky.social @jhdcate.bsky.social and coauthors on a great C-GEM + @innovativegenomics.bsky.social collaboration! #NSFfunded #RNAsky

Some recent highlights:

> Our recent ribosome engineering paper: x.com/eszter_cs/st...
> Our recent data analysis tool software paper: x.com/eszter_cs/st...
> Our absolute fluorescent protein quantification paper: x.com/eszter_cs/st...

Time for a proper intro: 👋 I am a group leader @ Leeds, focused on the study and engineering of translation control in bacteria.

Our interests span 🦠 Synthetic biology 🧬 Protein synthesis 🎨 Fluorescence 🧮 Quantitative biology and 📈 Data analysis.

Lots going on over the next few weeks, stay tuned!

Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg.
Come and join us at @ImperialChemEng!
Apply at the link below:
www.imperial.ac.uk/jobs/search-...