A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
Excellent work by @juliaeckert.bsky.social- now online!
What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?
I'm @juliaeckert.bsky.social. Let's explore some analysis software!
Got this fantastic opportunity to attend a special interest symposium at MIMS2025, and present a poster about my ongoing scRNAseq work. Brilliant talks and engaging discussions- thank you Australian and New Zealand Society for Immunology for hosting such an insightful event! #scrnaseq #immunology
How do epithelia adapt to mechanical stresses? What roles do junctional complexes AJs & desmosomes play in this mechanotransduction?
Check out our new review article by @juliaeckert.bsky.social & Virgile Viasnoff, discussing these ideas! 👇
Congratulations Caren - this is wonderful news and we are all delighted.
Congratulations @juliaeckert.bsky.social for this feat!
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
How is extrusion of infected host cells related to ERK (extracellular signal-regulated kinase) activity?
Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.
Happy to share our new publication in
@naturematerials.bsky.social
on mechanical cell competition! Great collaboration between our CAM team, Chavrier's and Doostmohammadi's. Special congrats
@luanger.bsky.social, @andreasschoenit.bsky.social, Siavash Monfared! 🎉
www.nature.com/articles/s41...
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
This dot is a region that intersect multiple cell junctions in an epithelia. These dots act as tiny anchors of cell contacts and they’re critical for epithelial coherence during homeostasis AND development.
I’m @katecavanaugh.bsky.social and I’ll be your guide on this 🧵 about tricellular vertices.
ICYMI: Discover new insights on chromosome size sensing by kinetochores, mechanical resistance at tight junctions, force-exerting focal adhesions formed by T cells, and how nuclei serve as mechanical bumpers, in our new #Mechanobiology collection 👉 https://buff.ly/3EK0uaq
🚨 We are thrilled to announce our amazing list of keynote speakers!!
@PCusachs
@GeorgHalder
@hirashima0203.bsky.social
@iberd.bsky.social
@johannaivaska.bsky.social
@gijsjekoenderink.bsky.social
@laurentnguyen.com
@renkawitzteam.bsky.social
@Sixt_Lab
...
Epigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...
Want to learn more about cell extrusion? What causes it and why is it essential? Check out this fantastic thread by our student @zoya-mann.bsky.social elaborating on the epithelial mechanics of cell extrusion!👇
Follow @epimechfc.bsky.social for more such cool threads..
My lab at the Max Planck Institute for Molecular Biomedicine in Muenster, Germany offers postdoc positions in stem cell mechanobiology. www.mpi-muenster.mpg.de/departments/... drop me an email
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Roffay, C., Chan, C. J., Guirao, B., Hiiragi, T., & Graner, F. (2021). Inferring cell junction tension and pressure from cell geometry. Development (Cambridge, England), 148(18), dev192773. #EpithelialMechanicsReview
journals.biologists.com/dev/article/...
Check this out!👇
Our new work reveals anilin’s putative role in mediating actomyosin remodeling and membrane composition
Two post-doctoral positions to study the mechanisms of epithelial homeostasis are available in the laboratory of Professor Alpha Yap @yap-lab.bsky.social (Institute for Molecular Bioscience, IMB, University of Queensland).
focalplane.biologists.com/cell-biology...
🚨Postdoc vacancy alert!
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Looking for a tool to analyse cell / tissue orientation on surfaces of 3D systems?
Check out this extremely user friendly tool generated by @juliaeckert.bsky.social in her new preprint👇
🚨Postdoc vacancy alert!
Interested to work on apoptosis/inflammation? Have some experience in biosensor-imaging and quantitative analysis of dynamic systems?
2 positions available for 2 years with potential of extension
Apply now! 👉
uq.wd3.myworkdayjobs.com/uqcareers/jo...
Thrilled to share our new preprint on detecting the nematic orientation field on surfaces of 3D multicellular systems!
www.biorxiv.org/content/10.1...
Huge thanks to all authors: @tobyandrews.bsky.social,Joe Pollard, @rashmi-priya.bsky.social, @yap-lab.bsky.social &Richard Morris
Any 3D systems?👇
