New article from Emmanuel Levy'Lab : they discovered that missense mutations in homomeric proteins can trigger supramolecular assembly but, remarkably, these folded protein assemblies are not toxic. A testament to cellular robustness!

Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...

👏 Congratulations @elevylab.bsky.social for your latest publication in @molsystbiol.org: Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system @mocel.bsky.social #UNIGE

🧬 New tool for U-ExM!
HAK-Actin is now available from Spirochrome → a reliable probe to label actin filaments in expansion microscopy.

Check it out at Spirochrome!
#UExM #Actin #Cytoskeleton #SuperResolution

🏅Congratulations to Emeritus Prof. Ueli #Schibler for receiving the #Kappers Medal from the #EBRS: the Society’s highest honor, awarded for outstanding contributions to biological rhythms research @sciencesunige.bsky.social @mocel.bsky.social #UNIGE
ebrs-online.org/index.php/abou

Congratulations @elevylab.bsky.social and collaborators for your latest publication in Cell 👏 and welcome to BlueSky 🦋@mocel.bsky.social‬ @sciencesunige.bsky.social

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...

🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...

d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1 Nature Metabolism - Zangari et al. show that d-cysteine targets NFS1, thus affecting Fe–S cluster biogenesis and impairing tumour growth.

Congratulations Emeritus Prof. #Martinou from @mocel.bsky.social and collaborators for your latest publication in #Nature #Metabolism 👏 rdcu.be/eASgF
👉 Check #UNIGE press release:
www.unige.ch/medias/en/20...

Spatio-temporal control of mitosis using light via a Plk1 inhibitor caged for activity and cellular permeability - Nature Communications Light is a powerful tool for controlling biological processes. Here, the authors demonstrate its use to modulate inhibitor activity and diffusion, enabling precise control of cell division in multicel...

Arresting mitosis with visible light! Brilliant Victoria von Glasenapp from the Gotta and Winssinger labs @UNIGE develops a cool photo-caged PLK1 inhibitor, which we deploy in 3D spheroids to control mitosis with exquisite spatio-temporal precision. Check out the original article: lnkd.in/eTnzy5Nc

Being part of the Pint of Science Geneva team is an absolute blast! 🚀 We’re working hard (and having a little fun too 😁) to bring amazing science talks this 19-21th May.
📌SAVE THE DATE: 19-21 May 2025 🧬
#Science #PintofScience #Geneva

pintofscience.ch

@pintofscience.ch @marinebrunet.bsky.social

Having a good time in the LS2 annual meeting @lifesciswitzerland.bsky.social 😊☺️