Brainwide blood volume reflects opposing neural populations - Nature Combined functional ultrasound imaging and Neuropixels recording of mouse brains identify two neuronal populations with opposing arousal-related activity and distinct haemodynamic response functions, that occur throughout the brain.

Nature research paper: Brainwide blood volume reflects opposing neural populations

go.nature.com/4vMzi14

Wanna do neuroscience in Paris but can't find interesting lab?

Want to come do a sabbatical but don't know who to collaborate?

Check this webpage aggregating ~all the neuroscience labs (+200) in Paris.

⚠️only the information of 'verified' profiles is reliable⚠️

Please retweet 🙏

parisneuro.fr

Nos super offres || Postdoctorate Researcher (F/M) Anyone who has experienced an all-nighter knows that sleep regulates our emotions. As an example, mood, anxiety, and stress disorders are all associated with the dysregulation of a specific phase of sleep: rapid-eye-movement (REM) sleep. Surprisingly, most sleep researchers focus on the other and most abundant phase of sleep, non-REM (NREM) sleep. In the past years, we have discovered an extreme pattern of neural and vascular activity, affecting virtually all brain regions (with a specific pattern in the amygdala, the brain “hub” involved in emotional processing) specifically occurring during REM sleep (see image). We aim to dissect the generative mechanism of these vascular surges and interrogate their function, in relation to emotional memory and brain clearance processes. We will use a set of innovative technologies including functional ultrasound (fUS) imaging, electrophysiology, fiber photometry and optogenetics in naturally sleeping rodents, as well as advance analysis methods

Apply here: offres.institutducerveau-icm.org/en/jobs/1999...

New article with @oudietted.bsky.social and the @dreamteamicm.bsky.social

Dream-like mental states can occur during wakefulness

Published now in @cp-cellreports.bsky.social

www.cell.com/cell-reports...

Congrats to Nicolas Decat!

New paper out 🎉

Awake fUSI is powerful, but motion can strongly bias the data, even in head-fixed experiments.

In this paper, we tried to systematically characterize those artifacts, benchmark denoising strategies, and turn that into practical recommendations for awake fUSI of mouse brains.

1/12

My group is hiring a postdoc candidate on a fully-funded 2 year postdoctoral position (renewable depending on funding availability). You will use functional ultrasound imaging, electrophysiology and optogenetics to decipher the neurovascular mechanisms of sleep and their role in memory processes 💤.

⚠️ Postdoc Opportunity in System Neuroscience at the Paris Brain Institute ⚠️

Feel passionate about neuroscience and sleep 🧠? Want to learn cutting-edge techniques 🔬 to answer exciting basic science questions? Want to work in a multidisciplinary environment at the heart of Paris 🏨?

Come join us !

@Anthony nous a d'ailleurs ouvert les portes du laboratoire MECADEV ou nous avons pu voir comment fonctionne la recherche chez les reptiles

Ce que la respiration révèle de nous | Tangram | Ausha Respirer, c’est automatique. Mais si le souffle permettait de comprendre le cerveau, la santé… et même d'apprécier l’art ? Dans cet épisode de Tangram, la respiration devient un terrain d’exploration ...

Merci a Sarah-Lou Lepers du podcast Tangram de @psl-univ.bsky.social d'etre venue nous interroger au @mnhn.fr avec @anthony-herrel.bsky.social pour parler de respiration et du sommeil des reptiles🦎 !!

Lien vers l'episode: podcast.ausha.co/tangram/ce-q...

Our study on infraslow rhythm during reptile sleep made the cover of Nature Neuroscience this month !! The outcome of a 6-year endeavour with PA Libourel and colleagues. So happy to see this flashing chameleon out there 🎉 !

Congrats @dlevenstein.bsky.social !!

Thanks @adrian-du.bsky.social !

What a nice piece of signal :)

Neuroscience has a species problem If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle.

If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle rather than an afterthought, writes @suthanalab.bsky.social.

#neuroskyence

www.thetransmitter.org/animal-model...

New paper alert! 🚨

We found that the brain's compass is remarkably stable at two scales

1️⃣ the system maintains its internal organization for weeks
2️⃣ It "remembers" its orientation for weeks, even after a single visit

This may be key to how the brain aligns its other maps.

Paper: rdcu.be/e3waP

The academic community failed Wikipedia for 25 years — now it might fail us Artificial-intelligence systems are feeding on Wikipedia without giving back, and academic indifference is threatening the survival of what is arguably the most widely used reference work on the plane...

"The time for passive consumption has expired. Every scholar should begin contributing their expertise to Wikipedia — not as charity, but as a core duty"

www.nature.com/articles/d41...

A commentary on reptile sleep, with recommendation from @anitaluthi.bsky.social @labluthi.bsky.social

Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...

Very happy to have contributed to this wonderful/tentacular work alongside so many amazing colleagues and friends!

It opens up new ways of understanding grey matter heterotopia associated with altered cortical function and #epilepsy in humans.

🧠🧪🔥

www.nature.com/articles/s41...

Thanks @kasumbisa.bsky.social !!

Thanks!

Thanks a lot @dlevenstein.bsky.social !! These NREM packets/cycles are indeed mysterious :)

Thanks @thomasandrillon.bsky.social !!

Thanks @apeyrache.bsky.social !!

A new comparative study of seven lizard species, including chameleons and bearded dragons, finds an ancient sleep rhythm conserved over millennia.

By Lauren Schenkman

www.thetransmitter.org/sleep/snoozi...

Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...

Many thanks to all co-authors and collaborators across the years: Chloe Froidevaux, Julien Schmidt, Baptiste Barillot, @mickaeltanter.bsky.social , Anthony Herrel, @marksblumberg.bsky.social and Paul-Antoine Libourel.

Read the full paper here: rdcu.be/eWJHb 8/8

Our findings challenge the notion that REM sleep “exist” in lizards but instead give a central place the infraslow rhythm, as a conserved fundamental building block of sleep architecture, dating back its apparition to the common ancestor of amniotes about 320 million years ago. 7/8

Finally, skin brightness – but not skin color – recorded in darkness in the sleeping panther chameleon oscillates at this infraslow rhythm, possibly reflecting blood oxygenation, and bouts of eye movements occurred markedly during one half of the cycle, which could be a marker of vigilance. 6/8

Functional ultrasound imaging showed that the whole brain oscillates at this infraslow rhythm, with blood flow coupled to neural signals during sleep in the bearded dragon and during NREM sleep in mice - but that this coupling disappears during REM sleep (in mice) and wake (in both species). 5/8

All 7 species recorded -the tokay and leopard geckos, the Sudan plated lizard, Argentine tegu, Egyptian rock agama, bearded dragon and panther chameleon- show brain waves synchronized with heart rate, respiratory rate, muscle tone and eye movements - as previously demonstrated during NREM sleep. 4/8

By recording in seven evolutionarily-distant lizard species, we show that neural signals display an infraslow rhythm (period ~100 sec) during sleep, like that previously described in mice and humans (period ~50 sec). The longer period in reptiles could be explained by their lower temperature. 3/8