The automated computational workflow QUICHE reveals structural definitions of antitumor responses in triple-negative breast cancer - Nature Cancer Ranek et al. developed a computational method that analyzes proteomic imaging and detects differentially enriched cellular niches, including low-prevalence niches. They applied this tool to inform the...

🌟Out today in Nature Cancer, two automated tools to analyze prognostic spatial features of TNBC

by Michael Angelo & co @joleneranek.bsky.social @noahgreenwald.bsky.social

QUICHE detects differentially enriched cellular niches, including low-prevalence niches.

www.nature.com/articles/s43...

This month’s cover illustration depicts the repopulation of cardiac-resident macrophages with cardioprotective monocyte-derived cells as chemotherapy-guided patchwork mending of the cardiac macrophage pool.

The January 2026 issue of #ScienceImmunology is out!

This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu

I had a fantastic time working with Allyssa Phelps on this project and our team of co-authors. @mcmasteruniversity.bsky.social

Pathogenic IgE-fated memory B cell responses retain functional plasticity Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling.

Thrilled to kick off the new year with our paper on memory B cell plasticity, now out in Science Immunology! Here we explored whether allergen-specific memory B cells can deviate off their IgE trajectory.

www.science.org/doi/10.1126/...
@sciimmunology.bsky.social

Pathogenic B cell responses to allergens are reprogrammed by blockade of IL-4 and IL-13 signaling @sciimmunology.bsky.social @kellybruton.bsky.social @mcmasteruniversity.bsky.social
www.science.org/doi/10.1126/...

Registration has officially opened for the 4th annual Spatial Biology Summit! Join us in person or virtually this September for an incredible lineup of speakers angelolab.com/spatial-biol...

Would love to be added to the list!

B cells in non-lymphoid tissues - Nature Reviews Immunology B cells are major drivers of systemic immunity, but they also act locally in non-lymphoid organs. This Review highlights new insights into mechanisms of tissue B cell function as well as efforts to le...

Excited our review on B cells in non-lymphoid tissues is out now! Across infection, cancer, autoimmunity and at homeostasis B cells are functioning in non-lymphoid tissues. @natrevimmunol.bsky.social Check it out! doi.org/10.1038/s415...