🆕🔥🔥CloCeBa RCT
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...
This is fantastic 👏👏👏👏
Over 300 NIH workers have signed a letter to Bhattacharya (the guy who pushed for mass infection during the COVID pandemic) asking him to stop destroying U.S. science & health care
The public can add their name in support (I did that) here:
actionnetwork.org/forms/add-na...
Did you know..75% of wine has significant levels of azole antifungals in it? (German wine anyway)
Potential consequences for driving resistance...
#IDSky #ISHAM
@steventong.bsky.social presents the results of the PSSA domain of the SNAP 🫰 trial - the worlds largest trial of staph aureus bacteremia - at #ESCMID2025
fluclox resulted in higher mortality and more AKI compared to penicillin for PSSA
Excited to announce that we randomised our first patient in the @roadmaptrial.bsky.social today! First of thousands, answering important questions in prosthetic joint infection. See roadmaptrial.com for more deets. #IDSky #PJI #ROADMAP
I signed. Only problem is you have to have a us phone number, US citizens who live abroad don’t…
They are the BEST! That Cartoon speaks so much truth
Same here. This cartoon captures it for me
We use 6 weeks and then Switch to oral Alternative or prolong initial iv. Not sure whether one can just repeat the 1.5g twice again. If Someone has data please share!
In Europe they priced it so it comes out the same cefta Avi PLUS Aztreonam or Emblaveo
Just cefazolin iv initially and then oral Cotrim 960mg TID if kidney and potassium good, otherwise doxy if sensitive or Levo Rifa if others not an option.
In Germany it is BPaL/M , I fell better using Moxi also when MDR and only 6 months. The half life of Bedaquiline makes me nervous about resistance though. That stuff hangs around for ages after the other drugs have been stopped. Why is it not stopped early?
ID gurus - what are your thoughts on the optimal tx for S. pneumo meningitis that is pansensitive?
ESCMID guidelines: PCN or amp/amox
IDSA guidelines: PCN
NICE guidelines: Ceftriaxone
PCN: lower risk of CDiff, antimicrobial stewardship rizz
Ceftriaxone: fewer infusions, pt already on this
#IDsky
Letter indicates resistance to shorter and less toxic drug regimens for multidrug-resistant tuberculosis (MDR-TB) is emerging and spreading between patients.
#IDSky
#TB
www.nejm.org/doi/10.1056/...
Wow will look into this and discuss!
Are you interested in joining a book club with a focus on #Tuberculosis? To create one we need your input! Please fill out this form to share your thoughts on the book club and let us know you'd like to be a part of it: forms.gle/vzKZSW2hTjoQ...
Depending on the bug my go to are, if sensitive, Cotrim, Linezolid, Moxifloxacin, Levo or Metro.
I did, but then had problems with failure. Now they get six weeks strict iv and if all good some mop up if there is still a little bit in MRI. Totally only my gut but seems to work.
Such a Common Problem and EVERY time I look it up to make sure nothing is forgotten and too often nothing is found…. Bookmarked for the next consult that is sure to come
As patient was off antibiotics for three months and PCR chronically low sensitivity not sure of the value.
Help #idsky I have a man with OM with MDR Acinetobacter After ORIF abroad. Hardware was removed, spacer implanted. Received 14 days effective treatment 3 months ago. Then stopped 🤷🏽♀️. Now new hardware placed in 4/4 tissue Cultures no growth. Shall I treat anyway or just take it as a win. No histo.
