Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...
The Golgi may have begun as just an appendage of the ER but now it’s practically the tail wagging the dog.
Yes, that's fair. Fortunate that the shit-talker turned out to be wrong. Feels karmically good when that happens.
Oh, was he an unpleasant chap? His stubborn disagreements with Ramon y Cajal et al are the stuff of legends, but I have not read about him being personally disagreeable.
On April 19, 1898, Camillo Golgi first described what we now call the Golgi apparatus - a structure so striking and unusual that it took more than 50 years for scientists to accept it wasn’t just an artefact.
April 19 is #GolgiDay! Celebrate the cell’s most iconic and best organelle.
Ah yes fair. I second your opinion of Lockwood.
Wuthering Heights
Intense, obsessive love. A dark, gothic atmosphere. Morally complex characters.
A bold, unconventional style (especially for its time) and timeless themes of passion, revenge, and class.
All set against the stormy, beautifully rendered Yorkshire moors.
What’s not to love?
Evolutionary landscape of endomembrane systems. On top are two possible endomembrane systems, represented as directed graphs (pER: proto-endoplasmic reticulum; PM: plasma membrane; IC: intracellular compartment). In the layer below, endomembrane graphs are represented as nodes (white dots) connected by evolutionarily viable transitions (red lines). Collectively these dots and lines define an evolutionary landscape. The landscape breaks up into less functional (left) and more functional (right) endomembrane systems, introducing a selective bias.
How did eukaryotic cells get their Golgi, endosomes, lysosomes and other endomembrane compartments? We show that endomembrane evolution depends on long periods of neutral molecular exploration, punctuated by sudden leaps.
New preprint: www.biorxiv.org/content/10.6...
Preprint from @thattai.bsky.social provides an elegant solution to a profound question: How can evolution – driven by gene duplication, deletion, and mutations produce complex endomembrane systems?
Punctuated Evolution of Endomembrane Compartments in Proto-Eukaryotes
www.biorxiv.org/content/10.6...
🧬 Last call to join us in Cambridge for #EMBOMBoA26 (July 6th-10th)!
We are just one week away from the registration and abstract submission deadline for the EMBO Workshop on the Molecular Biology of Archaea!
Whoa. The clearing worked so well that half the Falcon itself is no longer visible.
This is how we work on our ER stress
I feel relaxed
I am so happy to see @stedhammer.bsky.social last thesis chapter taking the shape of a publication. We looked into the role of the elusive GGAs cargo sorting adaptors. Alex‘s works hints at a role in the modulation of the binding of AP-1 adaptors to its clients #membranes #trafficking #CRISPR
The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with ideas reshaped how we think about cellular organization. #InMemoriam from @adamgrieve.bsky.social and colleagues: rupress.org/jcb/article/...
Credit: Mylan Ansel
Expansion microscopy of a loricate choanoflagellate, generated by Mylan Ansel in our lab 🤩
(yes, the lorica expands. No, we don't understand how either)
Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex...
@embl.org
#JobOffer We’re recruiting a tenure-track group leader working on cell metabolism (broadly defined, including lipid metabolism, organelle bioenergetics, etc.). Happy to chat informally about the department: great science, great people, and strong collaboration opportunities! Reposts appreciated 🙏
A young barmaid behind the bar at the famous French nightclub Folies-Bergère is staring forward in a bored, introspective way. Behind her is a mirror which reflects the lively scene. At the top left you see the green shoes of a trapeze artists. More importantly, at right you see the back of the barmaid, and see that she is face to a man who leans close and seems to be requesting something. This is Manet's famous painting "A Bar at the Folies-Bergère": https://en.wikipedia.org/wiki/A_Bar_at_the_Folies-Berg%C3%A8re
The perspective looks all wrong. You're staring straight at this barmaid, but her reflection in the mirror is way off to right. Even worse, her reflection is facing a guy who doesn't appear in the main view!
But in 2000, a researcher showed this perspective is actually possible!
(1/n)
India won their second cricket T20 World Cup in a row and I caught myself thinking: “Focused strategy, complementary expertise, efficient teamwork, ambitious objectives, coordinated execution, consistent performance, high-impact outcome…”
Grant application in progress, obviously.
Yup, heat could also make it go bad. It might also look yellowish, in addition to being more viscous and autofluorescent.
For once I'd follow the instructions, "store in a cool, dark, dry place!"
I'd just get a new bottle; this one's gone bad. Immersion oil degrades with heat, light, air, or maybe even some contamination got in (water, old oil from a slide).
strong illumination (esp. UV / blue) can photo-oxidize some immersion oils. That can increase autofluorescence and make the oil thicker / viscous over time. Often happens with older/contaminated oil.
Best buddies? More like budding buddies 🪼👯♀️✨ Six stages of asexual budding in Hydra to generate new genetically identical individuals (clones). 🟣: collagen 🟢: stem cells. 📸 Image by Ben Cox #FluorescentFriday
I know this guy very well because it's me! 😅
Thank you for this great opportunity!
We are very proud to present our newest paper on the role of Wnt signalling in abscission dynamics in stem cells! A brief thread to entice you to read Snježana’s exciting foray into signalling.
I had fun writing this N&Vs on two fascinating new papers on centromere evolution in yeast. If you’re interested in how centromeres adapt yet stay functional, here’s my take. rdcu.be/e6DD0 @nature.com @gautamdey.bsky.social @gsherloc.bsky.social @helsenjana.bsky.social @maxhaase.bsky.social
My writing technique
A wonderful collection of contemporary topics and perspectives on secretion and Golgi biology edited by Akihiko Nakano and Jaakko Saraste.
The Golgi Network, Volume II @SN and link.springer.com/book/10.1007...
But The Matrix was released when I was finishing high school.
Very recent movie.