Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome A previously entirely unknown mode of TLR signal transduction is elucidated.

#MysterySolved! Wellcome to the #TRIFosome! Kudos to @clarebryant.bsky.social & friends for visualizing filamentous TRIF @ Science Advances & showing that a supramolecular organizing center #SMOC is required for NfKB, not TBK1, signaling!! www.science.org/doi/10.1126/...

Next on Inflammazoom gasdermins with Katia Cosentino and Tanita Wein Monday at 1 GMT

Sculpting Innate Immunity The immune system sustains human health via the complementary action of its two branches: the innate and the adaptive immune systems. Precision modulation of innate immunity can unlock transformative ...

Potential new funding opportunities in innate immunity 😀 www.aria.org.uk/opportunity-...

The innate immune system is our first line of defence, but its potential remains untapped. In our latest opportunity space, PD @bscwang is asking: what if we could shape innate immunity with precision + accuracy? Read the doc and share your feedback: link.aria.org.uk/sii-bs

Thanks so much for all the kind messages

Thanks to our fab Monday Inflammazoom speakers @mere_conjecture and @keshu_VRimmChhttps catch up here://events.abcam.com/hub/events/c3dfed16-4376-4e2a-ab40-be973edd6855