Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome A previously entirely unknown mode of TLR signal transduction is elucidated.

#MysterySolved! Wellcome to the #TRIFosome! Kudos to @clarebryant.bsky.social & friends for visualizing filamentous TRIF @ Science Advances & showing that a supramolecular organizing center #SMOC is required for NfKB, not TBK1, signaling!! www.science.org/doi/10.1126/...