Very happy to see this new and improved IG genetic resource for Rhesus Macaque published today in Immunity! An enjoyable and fruitful collaboration with Steve Bosinger & team (Emory), @guryaari.bsky.social, @ayeletperes.bsky.social and @williamlees.bsky.social - More to come!
doi.org/10.1016/j.im...

Happy to see this work on IG light chains from @e-engelbrecht1.bsky.social in press www.nature.com/articles/s41...
How else will germline variation impact the expressed repertoire? Can't wait to see!
Thanks to awesome collabs:
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social

Ready to make your mark?
Accept the challenge 👇 🔗: kaggle.com/competitions...
#AIRR #Competition #DeepLearning #ComputationalBiology
@victorgreiff.bsky.social @chakri.bsky.social

Why you should join NOW: - The clock is ticking (ends Dec 17). - Top minds are already competing. - The prizes are exceptional: cash + a high-impact publication.
Don’t get left behind. This is your chance to contribute to cutting-edge science. #Bioinformatics #AI

Your mission: Predict disease from T-cell repertoires and identify the key sequences.
This is more than a prediction task, it’s about finding signals that could lead to new diagnostics & therapeutics. The data is complex, unpublished, and waiting for you. #immunoinformatics

The AIRR-ML-2025 challenge is LIVE on
@Kaggle, but the real question is… are you up for it?
We’re challenging the best in #MachineLearning & #DataScience to decode the immune system. Think you have the skills? Prove it.
💰 $10,000 prize pool 📄 Co-author a @NatureMethods
paper

The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data.
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates interactions between antibodies and other immune receptors and effector cells, directing cell killing and the cleara...

Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social

www.cell.com/cell-genomic...

Check it out!
Highly recommended for anyone passionate about ML/AI or computational biology and immunoogy.

The gremlin in the works: why T cell receptor researchers need to pay more attention to germline reference sequences The rise of T cell receptor (TCR) sequencing technologies is driving both new understandings of the immune system and the development of novel clinica…

Hi. If you're interested in learning more about the state of play in IG and T cell receptor gene curation, check out these articles:
www.sciencedirect.com/science/arti...
@jamieheather.bsky.social @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @elisarosix.bsky.social

🚨 Publication Alert!

AlignAIR is live, a deep learning–powered tool for aligning BCR/TCR sequences:
👉 alignair.ai

Explore the paper for results and methodological details:
📄 lnkd.in/dKY5fPZz

It’s been a long, creative, and rewarding journey with an amazing team.

We’d love to hear your feedback!

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...

Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...

A truly enjoyable and collaborative effort—this is what science should be all about!

The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...

Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social
www.biorxiv.org/content/10.1...

Looking forward to hearing from the great speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the program and register for this free virtual meeting 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin... @immcantation.bsky.social

Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...

Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social

www.biorxiv.org/content/10.1...

An unbiased comparison of immunoglobulin sequence aligners Abstract. Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is critical for our understanding of the adaptive immune system’s dynamics in health an

Check out our new publication: An unbiased comparison of immunoglobulin sequence aligners.
academic.oup.com/bib/article/...