Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
For me, the most maddening thing is when AI boosters, or detractors, all seem to agree that AlphaFold is an unmitigated good and useful tool showing the power of AI.
I disagree. It's hit and miss. And the misses are REALLY expensive. Especially when the conversation suggests it is ALL HIT.
I don't think people fully appreciate how apocalyptic things are for US science. I haven't had any new funding since 2024, but I'm still ok since typical grants are for three years. This means next year I will be completely out of funding and will have to fire everyone in the lab. It's not great.
A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...
So excited to be drowning in new "findings". Coming soon to a journal near you! 🫠
github.com/aiming-lab/A...
Federal funding for US biomedical research is moribund.
Since October 1 2025, NIH is -80% in new grants and -70% in values (total dollars).
Labs are closing down and researchers are leaving science.
To what end?
Do folks have a preferred protocol for bleaching fluorescent proteins prior to doing Immunofluorescence?
I tried a 3% H2O2 + 12mM HCl solution but I had severe cell detachment problems (despite everything being fixed).
@science.org Evolution of error correction through a need for speed | Science #evolution 🧬🔬 www.science.org/doi/10.1126/...
Insane that anyone can just unleash hundreds of glorified spam bots on the public internet and harass people, with little to no repercussions. The person who fired up the agent might not even know that it’s doing this!
How are we as a society going to handle BS at this scale?
Absolutely wild timeline we live in
TLDR: An agentic AI bot writes a takedown blog post of a matplotlib maintainer after he rejects its pull request. @arstechnica.com screws up and use AI to write a piece about the incident which hallucinates quotes. 🤦
theshamblog.com/an-ai-agent-...
🤩
Interesting study from *Anthropic* that found that AI use didn’t significantly speed up development on a novel task (w/ new Python async lib) but it did hurt understanding. Unsurprisingly, AI seems best at regurgitating common patterns and isn’t that helpful for novel ones. arxiv.org/pdf/2601.20245
an insect, a bird, and an elephant visualized with unit height scaling. insect is landscape shaped and the elephant is portrait shaped
Why is it that small animals like insects have a landspace body plan when viewed head-on, but larger animals like elephants are taller than wide?
With @m-v.bsky.social, we find out in our new preprint titled 'Size and shape of terrestrial animals' - arxiv.org/html/2602.00...
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
For all the talk about accelerating science, tools like this will likely slow things down because we have wade through mountains of AI garbage. The consequences need to grow for faking results.
Peer review science relies, more than we care to admit, on what @zey.bsky.social calls "load bearing frictions" that make it difficult to fake good science, and on trust that most ppl also value science itself & won't cheat just for personal gain. This creates the wrong environment for that to hold.
Thanks for linking the actual study. I dunno, seems pretty interesting?
They're using multilevel mixed-effect models (pg 21) to track the same person over time to see how their relationship satisfaction improves at time t+1, given a time-saving purchase at time t, vs original satisfaction at t-1
Blog post: Chance favors the (theoretically) prepared mind
Data is big, machines are learning, so what good is theory anyway? Isn't most discovery driven by serendipity anyway, with theory mostly a "post-mortem"? I argue that this view discounts the value of theory.
open.substack.com/pub/arjunraj...
Good review on what’s going on at NIH.
“Polling consistently shows strong majorities favor federal investment in health research. The dismantling we’re witnessing is instead the result of a political moment in which a minority viewpoint holds disproportionate power.”
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
Wait, it’s playing here. Amazing! bsky.app/profile/hbra...
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
Movie doesn’t seem to be playing 😞I would be super interested to see its motility!
1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1...
Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.
Really cool work! Congrats @zjmaggiexu.bsky.social and @cellraiser.bsky.social!
Congrats Dr Sachweh! 🫡😁
This awful news…we’ll miss Zara deeply :(
Iconic!
I had a great time presenting at the LLHF Annual Meeting. Lots of good feedback and lots to do!
