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Posts by Steve Diggle

Scanning electron micrographs of P. aeruginosa PA14 biofilms associated with EVPL bronchiolar tissue 48 h after infection.

Scanning electron micrographs of P. aeruginosa PA14 biofilms associated with EVPL bronchiolar tissue 48 h after infection.

Pseudomonas aeruginosa gene expression changes during established biofilm infection in a cystic fibrosis lung model. Published Open Access and fee-free in Microbiology using a Publish and Read agreement: https://doi.org/10.1099/mic.0.001678 #PublishandRead #MicrobioJ

6 days ago 5 2 1 0

Awful news. Sorry for your loss Rich.

1 week ago 1 0 0 0
Portraits of Paul Williams and Thomas Thompson featured in an interview.

Portraits of Paul Williams and Thomas Thompson featured in an interview.

Ahead of the 2026 Prize Medal Lecture, Thomas Thompson interviewed Professor Paul Williams to learn more about his career and how it feels to win a Microbiology Society prize.
Read the blog: https://microb.io/3PTIi44

#Microbio26

1 week ago 4 3 1 1
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Final version just published of our review on the ecological and evolutionary consequences of cooperation www.journals.uchicago.edu/doi/10.1086/... @ryosukeiritani.bsky.social @annadewar.bsky.social @asgriffin.bsky.social @lauriebelch.bsky.social
@asn-amnat.bsky.social

1 month ago 31 20 0 1
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New pre-print from us showing how biophysical traits like cell surface hydrophobicity dictate Pseudomonas aeruginosa aggregate architecture & shield cooperators from cheaters. May have relevance for understanding social evolution in chronic infections. 🧬🧫

doi.org/10.64898/202...

1 month ago 26 7 1 2

Was a pleasure hosting @billhanage.bsky.social for our @cmdi.bsky.social MicrobeATL event where he discussed the importance of the accessory genome in bacteria.

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A four-panel figure showing scanning electron micrographs of Pseudomonas biofilm on the surface of pig lung tissue. Aggregates of bacteria sit on top of a network of collagen fibrils, with some bacterial cells penetrating the collagen mesh.

A four-panel figure showing scanning electron micrographs of Pseudomonas biofilm on the surface of pig lung tissue. Aggregates of bacteria sit on top of a network of collagen fibrils, with some bacterial cells penetrating the collagen mesh.

Paper out! We used RNAseq to track changes in P. aeruginosa gene expression over 7 days of #biofilm infection in our #CysticFibrosis lung model. www.microbiologyresearch.org/content/jour... #MicroSky (1/n)

1 month ago 28 11 3 0
Logo of Microbiology Society featuring a stylized blue and green abstract M shape with bold text.

Logo of Microbiology Society featuring a stylized blue and green abstract M shape with bold text.

External Event Grant Awards of up to £750 are available for eligible members to use towards the registration, travel and accommodation costs to attend events between 1 May–31 August 2026. Apply before 15 March at 23:59 GMT: vhttps://microb.io/4qEISPC

1 month ago 4 2 1 0
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Studying adaptation at the invisible scale | PNAS In order to understand adaptation by natural selection, it is necessary to observe organisms in their natural habitat. For this reason, the field o...

Thank you to Doug Emlen and Matthias Fischer for the wonderful images we used in this figure, illustrating the parallels of studying adaptation across scales of visibility: scarab beetles and giant viruses www.pnas.org/doi/10.1073/... @stuwest.bsky.social

1 month ago 11 3 0 0
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Microbial Primer: Bacterial DNA supercoiling DNA in most bacterial cells is maintained in an underwound state. The DNA double helix responds to underwinding by adopting a minimum energy conformation through the supercoiling of the duplex, the fo...

Check out the latest Microbial Primer on DNA supercoiling www.microbiologyresearch.org/content/jour...

2 months ago 4 1 1 0
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<i>Microbiology</i> Editors: Call for expressions of interest

It’s the final week to apply for the Microbiology Editor role. We're looking for passionate experts to help shape the future of research. Submit your CV and cover letter by February 16: https://microb.io/4qKdgJ6

2 months ago 2 3 0 0
A cartoon showing the various targets of reconstructed eyesalve against Gram-positive and Gram-negative bacteria. It targets the cell membrane, as well as several intracellular targets including nucleotide biosynthesis. In S. aureus, it also affect quorum sensing.

A cartoon showing the various targets of reconstructed eyesalve against Gram-positive and Gram-negative bacteria. It targets the cell membrane, as well as several intracellular targets including nucleotide biosynthesis. In S. aureus, it also affect quorum sensing.

Remember the medieval remedy we reconstructed years ago? We've now dissected the various ways it attacks and kills bacteria! Preprinted & submitted, led by @tosinorababa.bsky.social & Jess Furner-Pardoe w/ many collaborators #MicroSky #Ancientbiotics www.biorxiv.org/content/10.6...

2 months ago 34 13 3 1
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<i>Microbiology</i> Editors: Call for expressions of interest

Only 2 weeks left to apply for the Microbiology journal's Editorial Board. Contribute to high-quality research and engage with the scientific community. Find out more and apply by February 16: https://microb.io/4qKdgJ6

2 months ago 2 2 0 0
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Microbial Primer: Ancientbiotics – making modern antimicrobials from historical infection remedies The modern antibiotic era began in the early twentieth century, but humans have long used materials from the natural world to attempt to treat the symptoms of infection. In this primer, we will discus...

New primer alert! Microbial primer discussing 'ancientbiotics': the search for 'new' antimicrobials from ancient remedies. @microbiologysociety.org @friendlymicrobe.bsky.social www.microbiologyresearch.org/content/jour...

2 months ago 4 3 0 0

Crazy!

2 months ago 0 0 0 0

That's crazy!

2 months ago 1 0 0 0

Come and join our editorial team

2 months ago 6 6 0 0

Thanks for writing

2 months ago 1 0 1 0
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Microbial Primer: Ancientbiotics – making modern antimicrobials from historical infection remedies The modern antibiotic era began in the early twentieth century, but humans have long used materials from the natural world to attempt to treat the symptoms of infection. In this primer, we will discus...

Why should microbiologists be interested in historical infection remedies, and how can we best investigate them for antimicrobial discovery? Thoroughly enjoyed co-writing this Microbiology Primer with @tosinorababa.bsky.social www.microbiologyresearch.org/content/jour... #MicroSky #Ancientbiotics

2 months ago 24 13 3 2
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<i>Microbiology</i> Editors: Call for expressions of interest

Do you want to be a journal editor and help shape the future of the @microbiologysociety.org? If so, check out this link Come and help shape the future of the journal Microbiology microbiologysociety.org/news/society...

2 months ago 3 5 0 0
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Improving a Tn7-based luciferase reporter system for promoter activity studies Single-copy chromosomal integration systems are essential tools for stable gene expression in bacteria, minimizing variability associated with plasmid-based systems. The Tn7 transposon-based system is...

New paper alert! An improved Tn7 lux reporter construct with basal lux expression eliminated. @microbiologysociety.org www.microbiologyresearch.org/content/jour...

2 months ago 2 2 0 0
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Clinical isolates from chronic wounds reveal strain-specific, alkyl-quinolone-independent competition in Pseudomonas aeruginosa- Staphylococcus aureus biofilms - PubMed <span><b>Introduction.</b> Chronic wounds are notoriously difficult to treat and are associated with decreased limb function, reduced quality of life and significant morbidity. Their recurrent nature, despite aggressive antibiotic therapy, is due in part to the presence of polymicrobial biofilms. <i>Pseud</i></span> …

Studies of clinical isolates show that P. aeruginosa and S. aureus interact in strain-specific ways. Surprisingly, competition doesn't always rely on usual chemical signals (AQs), highlighting the complexity of infections.

pubmed.ncbi.nlm.nih.gov/41533460/

#Microbiology #Biofilms #HealthScience

2 months ago 1 1 0 0
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From infestation to infection: a systematic review of arthropod-mediated microbial transmission in hospitals - PubMed Arthropods in healthcare environments commonly harbor clinically relevant and antimicrobial-resistant microbes, and limited but compelling evidence supports their potential role in patient transmission. Strengthened pest management and environmental hygiene are essential components of infection prev …

Insects in hospitals are potential disease vectors! 🪳🪰

A new systematic review shows that cockroaches, flies, and ants often carry drug-resistant bacteria and can transmit pathogens to patients. 🏥

pubmed.ncbi.nlm.nih.gov/41562025/

#InfectionPrevention #PublicHealth #Microbiology

2 months ago 2 3 0 0
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Rothia similimucilaginosa sp. nov., isolated from the human nasal cavity Four strains of a Gram-stain-positive, coccoid, catalase-positive, non-motile bacterium were recovered from nasal lavage samples collected from children in Wisconsin during the Spring of 2008. These s...

My lab has published our first paper! We previously showed that Rothia are associated with healthy nasal microbiomes and inhibit the pathobiont Moraxella catarrhalis. We now describe the novel species Rothia similimucilaginosa. Check it out here: www.microbiologyresearch.org/content/jour...

3 months ago 15 3 0 0
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Clinical isolates from chronic wounds reveal strain-specific, alkyl-quinolone-independent competition in Pseudomonas aeruginosa–Staphylococcus aureus biofilms Introduction. Chronic wounds are notoriously difficult to treat and are associated with decreased limb function, reduced quality of life and significant morbidity. Their recurrent nature, despite aggr...

P. aeruginosa can outcompete S. aureus in chronic wounds through strain-specific, alkyl-quinoline-independent mechanisms. This highlights why clinical isolates are key to understanding these infections. 🧬🧫 #Microbiology #Biofilms #Microsky www.microbiologyresearch.org/content/jour...

3 months ago 10 1 0 0
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Jobs View the current job vacancies at the Microbiology Society.

📢 We’re looking for Senior Editors to guide MGen's 'Pathogens and Epidemiology' section and promote high-quality research while representing the Microbiology Society. Apply by Monday 19 January 2026: microb.io/Vacancies
#MGen

3 months ago 3 3 0 0
From infestation to infection: a systematic review of arthropod-mediated microbial transmission in hospitals | Antimicrobial Stewardship &amp; Healthcare Epidemiology | Cambridge Core From infestation to infection: a systematic review of arthropod-mediated microbial transmission in hospitals - Volume 6 Issue 1

Our new review highlights that ants, cockroaches, and flies carry antimicrobial-resistant bacteria and fungi in hospitals. Better pest management is key to infection prevention. #ASHEJournal #microsky www.cambridge.org/core/journal...

3 months ago 15 4 1 0
Professorial Appointment within the Manchester Institute of Biotechnology:Manchester Institute of Biotechnology Applications are invited for a professorial appointment to be based in the Manchester Institute of Biotechnology (MIB) at the University of Manchester (UoM). The successful candidate will join a dynamic research environment at an exciting time and will help shape the institute research priorities and national/international profile. We are open to high quality applications from across the broad engineering biology and biotechnology landscape. Specific areas of interest include but are not limited to chemical biology of disease related proteins, natural product biosynthesis and enzyme discovery; structural biology and mechanistic enzymology; and microbial engineering.

Manchester Institute of Biotechnology is looking for a new Professor. There are a few priority areas including microbial engineering (broadly defined, from pathways to cells to microbiomes). Closing 12 Jan.
Join us in the best city in the UK 😜
www.jobs.manchester.ac.uk/Job/JobDetai...

4 months ago 15 25 1 1
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Society Event Grant – Annual Conference 2026 Awards of up to £350 (UK) and £650 (International) are available for eligible members wishing to attend the Annual Conference in Belfast. Application deadline is midnight GMT 02/01/26.

🔗Link here: microb.io/AC26Grant

#Microbio26 #Microbiology #MiM26

4 months ago 5 6 0 0

Agreed

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