Half of esophageal adenocarcinoma have no detectable Barrett's esophagus, but is the pre-cancer stage essential for cancer development?
Rebecca Fitzgerald lab & alumni analyzed epidemiological & molecular data of more 3800 patients and found a single pathway to EAC
www.nature.com/articles/s41...
Why should tumor whole genome sequencing (WGS) be done for cancer?
In real practice of medicine study of 888 patients with solid cancers, WGS directly led to clinical consequences in over 40%
www.nature.com/articles/s41...
Looking forward to London Calling 2026! I'll share how we built a long-read HRD test using adaptive sampling. With a single assay, we can now capture multiple complex biomarkers, dive deeper into individual tumours and uncover new layers of cancer biology. #nanoporeconf
More: echo.walls.io/cAgvWLR
Transformer-based AI has boosted
@nanoporetech.com
sequencing accuracy, but at a cost to portability due to GPU demands.
Our new work, spearheaded by
Sara Bakic, introduces Campolina link.springer.com/article/10.1... to improve nanopore signal segmentation for event-based mappers.
Last day at #InSiGHT2026 with a session for Early-onset colorectal cancers that I had the pleasure to co-chair. Thank you for thoughtful discussions with the speakers & audience !
Lastly, thank you for the support from @nanoporetech.com on the project and more updates to come!
Day 2 at #InSiGHT2026 with thought provoking talks on the molecular features of Lynch Syndrome. Thankful for the opportunity to give a talk in collaboration with Illumina Simeen and Shunhua Han on the newly released TruPath Genome.
Looking forward to the next 2 days of talks!
Wonderful opportunity to work on cancer genome reconstruction with long reads!
Looking for a postdoc in computational biology? We are looking for a postdoc candidate apply for the fellowship 'Juan de la Cierva' for a project on long-read transcriptomics, multiomics, spatial transcriptomics, single-cell long-reads. Deadline is approaching!! (December 10th)
The structure of the bacterial genotoxin colibactin bound to DNA shows how it might contribute to cancer risk @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Excited to see this thought provoking piece of work now published. So much more to learn about mutagenesis in healthy tissue.
Black and white portrait of John Gurdon, 1971
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.
Elegant work to unveil the etiology behind the ubiquitous SBS5 mutational signature. Glad to be in the audience to see this work presented and I have already put it on my reading list.
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
If you don’t have time to take a walk, then you don’t have time to do science. Charles Darwin would take two walks every day on his "thinking path", not as a break from science, but as a crucial part of it.
Excited for the talks on the amazing biology of ecDNA! Interested in ecDNA in esophageal cancers and long read sequencing? Always happy to chat!
#CancerGrandChallenges #CGCecDNA
Attending BRCA Symposium 2025 and enjoying a master class from Ralph Scilly on HRD. I will also start calling SBS3 bland from now on.
Interesting work from Khi Pin Chua, PhD on precise characterization of complex repeat regions in cancer genomes at #AACR25. Catch him at poster 2 in section 46 (#6288) until 5 PM! #PacBio
“If left unchallenged, a rising wave of white nationalism in many parts of the globe could threaten the progress that has been made in science — and broader society — towards a more equitable world,” writes Genevieve Wojcik in a Comment article for Nature. 🧬 🧪
We should catch up! Was looking around to see if you were here!
Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!
Maybe I need to look at some head and neck cancer to study both DNA repair and ecDNAs. Come look for me at #AACR25 if you like to chat!
Yes! - we are hiring @yale.edu - links below...
Highlights of day 1 of #MITS : @steverozen.bsky.social on Aristolochic Acids their effects on carcinogeneis
, @nlbigas.bsky.social on driver mutations in small clones in the bladder. Sir Mike Stratton on signatures stem of the colorectum @mollyprz.bsky.social elegantly solving the etiology of a Sig
A wonderful reminder that my time spent comparing all the ecDNAs in organoids from the @RFitzgerald_lab added new insight to how we can use tumour organoids as a model to study ecDNA.
The future of tumor organoids in precision therapy: Trends in Cancer www.cell.com/trends/cance...
And so it begins. I have been working in genomics / sequencing for more than 30 years but today is a particularly exciting day as I begin training on using the @nanopore MK1D sequencer which we will be using soon for student projects (and other things) at @ucdavis.bsky.social
The first Singapore Long-Reads Symposium was a success! A massive thanks to the speakers: Keynote Heng Li, Ken Sung @jonathangoeke.bsky.social , @msikic.bsky.social & industrial partners @nanoporetech.com , @pacbio.bsky.social , @awscloud.bsky.social MGI_Technology Next Level Genomics & NovogeneAIT
I'm happy to announce that my project to use @nanoporetech.com sequencing to study Early Onset Colorectal Cancer has been funded!
Our 2024 Wrapped! 🧪
- £173m awarded to our Cambridge Institute, @cruk-ci.bsky.social
- £58.7m to train clinician scientists
- 120,000+ people being recruited for the capsule sponge screening trial
- 3 cancer prevention vaccine projects
Read more about our progress this year 👇 cruk.ink/4iLz3ws
SPECIAL ISSUE! This month Genome Research publishes a diverse collection of research and review articles in a special issue highlighting advances in long-read sequencing applications in biology and medicine. Full issue links here: tinyurl.com/Genome-Res-3....