The @crg.eu 2026 International PhD Programme is now open! Join our international community in Barcelona: www.crg.eu/en/content/t...

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking - Nature Communications Here, the authors show how HSV-1 rewires the host cell’s chromatin architecture during lytic infection by hijacking transcription machinery and forming contacts between viral and host genomes.

The cold sore virus reshapes the human genome’s architecture, rearranging its shape in three-dimensional space so that HSV-1 can access host genes most useful for its ability to reproduce. Read full paper led by @piacosma.bsky.social in Nature Communications:

This is one of a kind research outreach event. Scientists and artists have gathered together to deliver this sensory experience!

The diffraction limit of light taken by storm Nature Reviews Molecular Cell Biology - Pia Cosma recounts the development of STORM, which was the first microscopy method to break the diffraction limit of light.

Excited to share our Journal Club discussion on the invention of STORM microscopy, just published in Nature Reviews Molecular Biology! @natrevmcb.bsky.social @crg.eu

rdcu.be/ekUL7

The diffraction limit of light taken by storm Nature Reviews Molecular Cell Biology, Published online: 06 May 2025; doi:10.1038/s41580-025-00856-xPia Cosma recounts the development of STORM, which was the first microscopy method to break the diffraction limit of light.

New Online! The diffraction limit of light taken by storm

ECaBox Symposium: Seeing the Future - EcaBox Register for the ECaBox Symposium: Seeing the Future on 3rd June 2025, a full-day event bringing together leading experts to discuss the latest advancements in eye disease, retinal regeneration, and t...

We're very excited to announce the ECaBox Symposium in Barcelona on the 3rd of June 2025. Join global experts exploring the latest innovations in regenerative medicine for eye disease. Organised by @piacosma.bsky.social. Registration is now open!

In a study published in Horticulture Research, a research team leveraged ATAC-seq technology to profile chromatin accessibility in P. expansum during its vegetative growth and infection phases.
#ATAC-seq #chromatin accessibility
Details: doi.org/10.1093/hr/uhae264

So, is it compaction or decompaction? Here is a notable alternative hypothesis: "Our data suggest that the process of..loop extrusion per se is not required for enhancer function..Rather, it is the chromatin compaction brought about by loop extrusion that may be the important factor to consider."

It was a pleasure to showcase our lab’s expertise in assays for DNA-protein interactions (ChIP & CUT&RUN), chromatin accessibility & more at #ABRF2025 (thanks for the invitation). A great discussion on how Epigenomics core @mdanderson.bsky.social is making impact to advance research missions.

Journal of Cell Science logo Meet the Editor at Biologists @ 100: Megan King Areas of expertise: Nuclear pores complexes, nuclear organisation, nuclear integrity, nuclear mechanics, chromatin structure and dynamics, mechanotransduction, quality control.

Our Editor Megan King @luskinglab.bsky.social is attending our Biologists @ 100 conference. Reach out to Megan if you have questions about submitting your research to JCS or visit our website to find out more: journals.biologists.com/jcs/pages/re...
#biologists100

Trying to understand drug mechanism of action? Epigenomics may be a great solution for you. Attend this free webinar March 26 at 11 AM ET to learn more: https://www.genengnews.com/multimedia/webinars/decoding-drug-mechanism-of-action-with-chromatin-mapping-assays/

🧪🧬 Curious how your drug actually works?

Join our free webinar TOMORROW, 11AM ET to explore how chromatin mapping assays can uncover drug mechanisms of action.

Great for drug developers + preclinical researchers in oncology, immunology, and beyond.

🔗 Register: www.genengnews.com/multimedia/w...

Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells - BMC Genomics Background The regulation of chromatin accessibility is essential in eukaryotic cells as one of several mechanisms that ensure gene activation occurs at appropriate times and in appropriate cell types...

Planarian stem cells have many unique properties, mediated in part by their dynamic chromatin state. The Duncan lab recently showed that chromatin remodeling protein BPTF is critical for maintaining these powerful functions.
bmcgenomics.biomedcentral.com/articles/10....

Single-cell expression during mouse gastrulation of genes enriched in probands with isolated congenital heart disease or neurodevelopmental delay and extracardiac findings. Single-cell RNA sequencing from mouse gastrulation for 28 genes associated with isolated CHD probands (in pink) or neurodevelopmental delay and extracardiac findings (in purple) are shown. On the vertical axis, cell types are sorted for heart (red), brain (blue), and other tissues (green). Expression levels are scaled to the greatest transcripts per million reads for each gene across all tissues. Chromatin genes are annotated with a white dot in the purple bar.

A genetic study of 11,555 people finds 60 genes implicated in congenital heart disease, a condition that affects 1–1.8% of all live births. The study could inform the development of early molecular diagnosis tools. In PNAS: www.pnas.org/doi/10.1073/...

Plasmodium blood stage development requires the chromatin remodeller Snf2L | Nature The complex life cycle of the malaria parasite Plasmodium falciparum involves several major differentiation stages, each requiring strict control of gene expression. Fundamental changes in chromatin structure and epigenetic modifications during life cycle progression suggest a central role for these mechanisms in regulating the transcriptional program of malaria parasite development1–6. P. falciparum chromatin is distinct from other eukaryotes, with an extraordinarily high AT content (>80%)7 and highly divergent histones resulting in atypical DNA packaging properties8. Moreover, the chromatin remodellers that are critical for shaping chromatin structure are not conserved and are unexplored in P. falciparum. Here we identify P. falciparum Snf2L (PfSnf2L, encoded by PF3D7_1104200) as an ISWI-related ATPase that actively repositions P. falciparum nucleosomes in vitro. Our results demonstrate that PfSnf2L is essential, regulating both asexual development and sexual differentiation. PfSn

Plasmodium falciparum's life cycle relies on Snf2L for gene expression control within its high AT content chromatin. Essential discovery! PMID:39972139, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-08595-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation Structural maintenance of chromosomes (SMC) complexes are thought to shape genomes by extruding DNA loops, but recent genetic tests have challenged the “loop extrusion hypothesis.” Here, Uhlmann explores whether SMC complexes might form chromatin loops by sequential DNA-DNA capture, akin to how cohesin establishes sister chromatid cohesion.

A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation

Human Body Single-Cell Atlas of 3D Genome Organization and DNA Methylation Higher-order chromatin structure and DNA methylation are critical for gene regulation, but how these vary across the human body remains unclear. We performed multi-omic profiling of 3D genome structur...

9/10 Preprint at www.biorxiv.org/content/10.1.... Data at huggingface.co/zhoujt1994/. Check it out if you're interested in epigenomics, chromatin structure and function, and single cell biology in diverse organ systems.

Metabolic early warning signals of epigenetic tipping points under chromatin modifier competition www.biorxiv.org/content/10.1101/2025.03....

Metabolic early warning signals of epigenetic tipping points under chromatin modifier competition www.biorxiv.org/content/10.1101/2025.03....

Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation Fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. Induction of early Notch s

Top-notch activation. Notch signals enhance effector CD8 T cell generation in #vaccination or infection. Fibroblastic reticular cells are the source of Notch signal. The signal is associated with chromatin opening in regions occupied by bZIP transcription factors.
@jem.org
doi.org/10.1084/jem....

Inside the nucleus, lncRNAs act as molecular architects, shaping gene expression and chromatin landscapes. But tracking them in action? That's the tricky part! Cutting edge imaging techniques are revealing how RNAs like Xist spread and silence genes, reshaping our understanding of epigenetics!

#ChromatinDays – Join Us!

SFB 1064's final annual meeting! Talks, reunion & BBQ Bash 🍖 on May 26-27. Guest speakers: former SFB & IRTG members. Alumni, don’t miss the BBQ & IRTG Satellite Session!

📢 Register now! Scan the QR code or visit: www.sfb1064.med.uni-muenchen.de/chromatin-da...

🐝 there!

3/ We developed a new approach to map the chromatin accessibility data to primary atlases using cisTopics loadings. We find that organoid cells recapitulate primary counterparts not only on transcriptomic, but also on chromatin accessibility level!

We thus propose that mitotic chromosome shape is dictated by Condensin-driven extrusion of long and overlapping loops up to a density set by chromatin self-repulsion.

Hey #ABRF attendees! Are you interested in setting up CUT&RUN chromatin mapping services?

Then make sure to see Cheryl Szany's talk about optimizing CUT&RUN services, TODAY at 4:30PM!

Stop by booth 103 for additional info and training opportunities to get started with CUT&RUN in your core today!

Studies on Gene Enhancer with KSHV mini-chromatin www.biorxiv.org/content/10.1101/2025.03....

Studies on Gene Enhancer with KSHV mini-chromatin www.biorxiv.org/content/10.1101/2025.03....

Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β | Nature Communications Single-strand breaks (SSBs) are one of the most prevalent forms of DNA damage found in the chromatinized genome and are repaired by single-strand break repair (SSBR) or base excision repair (BER). DNA polymerase beta (Pol β) is the primary enzyme responsible for processing the 1-nt gap intermediate in chromatin during SSBR and BER. To date, the mechanism used by Pol β to process a 1-nt gap in the context of chromatin remains poorly understood. Here, we use biochemical assays and cryogenic electron microscopy (cryo-EM) to determine the kinetic and structural basis of gap-filling DNA synthesis in the nucleosome by Pol β. This work establishes that Pol β uses a global DNA sculpting mechanism for processing 1-nt gaps in the nucleosome during SSBR and BER, providing fundamental insight into DNA repair in chromatin. DNA polymerase beta (Pol β) is the primary enzyme responsible for processing 1-nt gaps in chromatin during DNA repair. Here, the authors determine the kinetic and structural basi

Discover insights from 1-nt gap repair by DNA Pol β in chromatin! Using biochemical assays and cryo-EM, this study unravels the complex mechanisms in 123 characters. PMID:40097433, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57915-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@naturegenet.bsky.social editors Petra Gross and Chiara Anania will be joining the Keystone Symposia “Epigenetics in Development and Disease” & “Interplay of Chromatin Architecture and Transcription Regulation”. Please feel free to reach out to them if you want to discuss your research!

NEW PUBLICATION!

Researchers from the @r4knetwork.bsky.social just revealed the progressive chromatin rewiring induced by the ETO2::GLIS2 fusion in the onset of pediatric leukemia.

A collaboration between @gustaveroussy.fr, @institutimagine.bsky.social, & many more.

doi.org/10.1182/bloo...

CHROMATIN REMODELING FACTOR 28 and HEAT SHOCK FACTOR A2 activate BINDING IMMUNOGLOBULIN PROTEIN 3 under heat stress (Haiyan Li, Minmin Liang, Guohong Huang, Haiwei Fan, Ruiyao Liu, Lijun Cao, Minghui Lu) doi.org/10.1093/plph... #PlantScience