A beautifully crafted summary of the extraordinary discovery in the lab of my @mrclmb.bsky.social colleague @philholliger.bsky.social of a tiny RNA that can replicate RNA.

Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs

We are recruiting 2 postdocs to work on bacterial motility using a combination of cryoEM, FLM and MD. An exciting collaboration with Kirsty Wan @micromotility.bsky.social Wolfram Moebius @wolframmoebius.bsky.social and Daniel Kattnig. Please see links in the thread below!

If you’re attending #ACA2025 in Chicago, check out the talk by the amazing @alisiafadini.bsky.social. She’ll present new results on using experimental data (X-ray or #CryoEM) to guide AlphaFold even with very low resolution data! Session 2.1.3 at 11:10 on Sunday.

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Meanwhile, CryoEM continues to make strides: here, the swinging lever mechanism of the actinomysin power stroke is resolved in atomic- and time-resolved detail, via a myosin-5 mutant with slow hyrdolysis product release. Some very awesome single molecule biophysics! www.nature.com/articles/s41...

In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS www.biorxiv.org/content/10.1101/2025.03....

Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social

AlphaFold as a Prior: Experimental StructureDetermination Conditioned on a Pretrained Neural Network www.biorxiv.org/content/10.1101/2025.02.18.638828v1 #cryoEM

Job Opportunity at University of Leeds: Research Fellow in Structural Biology Are you an ambitious researcher looking for your next challenge? Do you have an established background in structural studies of amyloid aggregates and want to help to develop new routes to combat amyl...

Great opportunity to join the Radford / Ranson labs and the world-renowned Astbury Centre as a Research Fellow in Structural Biology! Please see jobs.leeds.ac.uk/vacancy.aspx...

Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis - Nature Structural & Molecular Biology Anti-NMDA receptor encephalitis is the most common autoimmune encephalitis. Michalski et al. reveal epitope diversity, conformational changes and functional impacts of the autoantibodies using cryo-EM...

www.nature.com/articles/s41... Our study on the structural and functional characterization of anti-NMDAR autoimmune encephalitis is officially published. Key findings include: (1) Autoantibodies from three distinct patients exhibited unique binding patterns, with two binding sites per tetramer. 1/n)

Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41...

We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.

Threads will follow!

Wow! Congratulations. I am curious how you could be sure the nanopearling you observed by EM were of axons and not subcellular compartments of other cell types (eg peripheral astrocytic processes) in the tissues?

We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!