Crosstalk between macrophages and fibroblasts contributes to inflammation and damage in giant cell arteritis AbstractObjectives. Giant cell arteritis (GCA) is a large vessel vasculitis characterized by arterial wall inflammation and remodeling. Macrophages and fib

academic.oup.com/rheumatology...

How do I get to #IVW2026? It is easy, with 100s of flights to Australia daily! Check out #Momondo for flight deals worldwide. While you're here, why not add a trip to New Zealand! vasculitis-melbourne2026.com, Registration opens on 28 March #11daystogo

Distinct landscapes of fibroblast subtypes in arteries of patients with giant cell arteritis AbstractObjective. Giant cell arteritis (GCA) is a systemic vasculitis of large- and medium-sized arteries characterized by granulomatous inflammation and

Happy to share our latest publication! Here we document the spatial distribution of fibroblast subtypes in relation to vascular remodeling in GCA. Great work by Shuang Xu William Febry Jiemy and Maria Sandovici!
academic.oup.com/rheumatology...

ANZVASC Bluesky account ✔️
22nd Int Vasculitis Workshop website ✔️
vasculitis-melbourne2026.com

All things #vasculitis in Melbourne Feb 2026. Key dates, things to do and promotional tools.
Come for exceptional research, learning and interactions,
And....a great trip to Australia and New Zealand!

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis - PubMed Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a prototypic autoimmune disease, with a subset of AAV patients manifesting anti-myeloperoxidase (MPO) IgG. Patients with AAV ...

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis - Nature Communications The etiology of autoimmune disease anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is still poorly understood. Here the authors associate anti-myeloperoxidase (MPO) IgM-express...

Does autoreactive IgM complement IgG in ANCA associated vasculitis? Interesting observations by the group of Hans Ulrich Scherer with contributions from the Vasculitis Expertise Center Groningen as part of a collaboration within the Target to B consortium.
www.nature.com/articles/s41...

AI analysis of clinicians' notes in medical records helps identify AAV AI analysis based on clinicians' notes in patient records can accurately identify cases of ANCA-associated vasculitis, a study found.

AI analysis of clinicians’ notes in medical records helps identify AAV

Happy 1-year anniversary today @bsky.app!

GM-CSF drives IL-6 production by macrophages in polymyalgia rheumatica Insight into the immunopathology of polymyalgia rheumatica (PMR) is scarce and mainly derived from peripheral blood studies. The limited data availabl…

New paper alert!
Here, we analyzed monocytes and macrophages across three compartments in PMR patients, circulation, bursa fluid and bursa tissue. Our findings revealed a complex cytokine network that drives the development of pro-inflammatory macrophages.
www.sciencedirect.com/science/arti...

We are excited to announce the upcoming thesis defense of Shuang Xu !
On February 12th 11 am, Shuang Xu aka Lia, will defend her excellent work on fibroblast diversity and function in giant cell arteritis. If you are interested in learning more, here thesis is available here: bit.ly/3EexTtU

Examples like this are why I am optimistic about the huge potential for AI to dramatically improve healthcare and health outcomes.

Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection - Nature Medicine Blood biomarkers in a middle-aged population suggest that SARS-CoV-2 infection is associated with greater brain β-amyloid plaque accumulation.

Blood biomarkers in a middle-aged population suggest that SARS-CoV-2 infection is associated with greater brain β-amyloid plaque accumulation. The findings published in Nature Medicine suggest that SARS-CoV-2 may increase the risk of future Alzheimer’s disease. #Medsky 🧪

Scientists flock to DeepSeek: how they’re using the blockbuster AI model Researchers are testing how well the open model can perform scientific tasks — in topics from mathematics to cognitive neuroscience.

DeepSeek's open AI model is giving scientists worldwide the opportunity to train custom reasoning models designed to solve problems in their disciplines.

https://go.nature.com/4hxoRGD

When Doctors With A.I. Are Outperformed by A.I. Alone Interpreting Some Surprising Results

Our op-ed @nytopinion.nytimes.com today addresses the surprising results of recent medical studies that showed A.I. alone outperformed physicians using A.I. W/@rajpurkar.bsky.social
Here is a summary Table, an overview, and a gift link to the op-ed
erictopol.substack.com/p/when-docto...

Immune control of brain physiology - Nature Reviews Immunology The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and explore how these routes are leve...

And it's out! The BIC lab presents our new perspective article on "Immune Control of Brain Physiology" - fresh off the press at
@natrevimmunol.bsky.social
nature.com/articles/s41...
wonderful synergy:
@marikovacs.bsky.social
@amaia-db.bsky.social
and @fakesamir.bsky.social

Our analysis revealed altered expression of key immune molecules on B cells in GPA, with FcγRIIB, BTLA, and CD21 linked to disease activity highlighting the intricate immune dysregulation in GPA. Future studies should explore underlying mechanisms and assess their clinical relevance.

Circulating B cells display differential immune regulatory molecule expression in granulomatosis with polyangiitis Spectral flow cytometry uncovers a distinct B-cell composition profile in granulomatosis with polyangiitis (GPA). GPA patients have altered expression of F

Our paper on deep phenotyping of B cells in PR3-ANCA+ GPA patients is now published!
doi.org/10.1093/cei/...

🌟 Join us! 🌟
We’re reaching out to vasculitis patients and clinicians to join us in the Technical Plausibility Testing of an AI Tool, which will take place throughout 2025.

Your expertise and insights can make a difference!

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Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV-154 in Adults With Glucocorticoid-Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial
https://pubmed.ncbi.nlm.nih.gov/39866124

This is the first post from the Vasculitis Expertise Center Groningen on Bluesky! Here, we’ll share updates on our research and teaching activities, as well as insights into vasculitis management and pathogenesis. #vasculitis #translational-research #immunology