New research sheds light on why Alzheimer's treatments targeting amyloid alone may not be enough 🧠

Prof @marcaurelbusche.bsky.social & Dr Robert Ellingford suggest the hallmark proteins amyloid beta and tau may work together to disrupt memory circuits 👉 ukdri.ac.uk/news-and-eve...

Rethinking neurodegeneration: How do brain circuits fail in early Alzheimer's disease? YouTube video by UK Dementia Research Institute - UK DRI

It was a pleasure to host @marcaurelbusche.bsky.social for a special UK DRI webinar last week on how circuits fail in Alzheimer's disease, and hear about his lab's recent incredible findings 🧠

If you missed it, catch up here 👇
youtu.be/JzPFyO4ef-I?...

How do brain circuits fail in early Alzheimer's disease? With Dr Marc Aurel Busche

🧠 How do brain circuits fail in early Alzheimer's disease? 🧠

Join @marcaurelbusche.bsky.social for the next research webinar in our 'Rethinking neurodegeneration' series, taking place 4-5pm (BST), Thurs 24 July 🗓️

🚨 Register for free today! 🚨 Full info 👉 www.ukdri.ac.uk/events/rethi...

I‘m excited to speak at this UK DRI webinar “Rethinking Neurodegeneration” on 24 July, discussing cell type- and circuit-specific vulnerability in early Alzheimer’s. #Alzheimers #Neurodegeneration #UKDRI

Alzheimer’s-linked proteins help to maintain healthy communication in the brain Researchers at UCL Queen Square Institute of Neurology have discovered that the amyloid precursor protein (APP) family is essential for healthy communication between brain cells.

Research led by @marcaurelbusche.bsky.social and Dr Samuel Harris (@uclqsion.bsky.social & @ukdri.ac.uk) has discovered that the amyloid precursor protein (APP) family is essential for healthy communication between brain cells.

Research led by Dr Samuel Harris and @marcaurelbusche.bsky.social reveals a role for the Alzheimer's-linked APP proteins in sustaining brain activity in healthy brains 🧠

The study provides insight into how their disruption could contribute to cognitive impairments👉https://buff.ly/KcwK7OQ

Closing date is June 12th - please do apply in case of interest!

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution - Communications Biology Three-photon in vivo imaging provides access to medial prefrontal cortex, hippocampus and spinal cord in mice at up to 1.7 mm depth of neurons, dendrites, spines, astrocytes and microglia.

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week.
www.nature.com/articles/s42...

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.

Apply here👇
shorturl.at/LpCAq

Deep-layer brain cells falter first in early Alzheimer’s A study led by Dr Marc Aurel Busche (UK DRI at UCL, UCL Queen Square Institute of Neurology) sheds light on the earliest stage of Alzheimer’s, identifying which layers and cell types of the brain are…

A study led by Dr @marcaurelbusche.bsky.social (@uclqsion.bsky.social, @ukdri.ac.uk) sheds light on the earliest stage of Alzheimer’s, identifying which layers and cell types of the brain are first affected.

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.

Apply here👇
shorturl.at/LpCAq

New research by @marcaurelbusche.bsky.social identifies where Alzheimer's begins in the brain, revealing which layers and cell types of the brain are first affected 🧠

The study opens up potential new pathways for targeted therapies👉https://buff.ly/4GlltQF

Very grateful to @ukdri.ac.uk , Medical Research Council, @ukri.org , @curealzheimersfund.bsky.social , @brightfocus.bsky.social , @alzassociation.bsky.social for the invaluable support!

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity and altered tuning of fa...

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...

Thank you so much for all the support.

Impressive research. We are proud to support your work!

Delighted to have played a part in this work, now out in @cellpress.bsky.social, where we show how soluble high molecular weight tau from Alzheimer’s brain suppresses burst firing in hippocampal neurons.

Grateful to @ukdri.ac.uk, medical research council, @ukri.org, @curealzheimersfund.bsky.social, @brightfocus.bsky.social, @alzassociation.bsky.social, and others for their support

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these ...

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...

New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠

The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6

Stelle als Oberärztin/Oberarzt: An der Universitären Altersmedizin FELIX PLATTER in Basel entsteht eine interdisziplinäre Verbindung von Klinik, Diagnostik und translationaler Forschung in Demenz/Alterspsychiatrie. Jetzt aktiv mitgestalten. www.felixplatter.ch/felixplatter...

Delighted to see the Synapsis Foundation & Race Against Dementia investing in the next generation of dementia researchers! Hopefully just a start of a growing UK-Swiss collaboration in this very important area.

Delighted to see this news! Rikesh is an outstanding colleague - creative, dedicated, and absolutely committed to the fight against dementia. He will be a tremendous asset to the new BHF-UK DRI Centre. Wishing him every success - they couldn’t have picked a better person!

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...

Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1...

Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...

On my way to UCL to give a seminar on all things #tau and #iPSC! Looking forward to hanging out with the @marcaurelbusche.bsky.social and @selinawray.bsky.social labs 😊

Struggling with my enormous Edinburgh-weather-appropriate but London-inappropriate coat on the Piccadilly line though 🫣