Blahopřejeme @zeptejsevedce.bsky.social a díky za všechny odpovědi!

🗣️ We were pleased to host Prof. Hosea M. Nelson (@caltech.edu, Pasadena, CA, USA) today, who delivered an invited lecture titled "Electron diffraction for chemical discovery and new reactions of carbocations".

#IOCBInvitedlecture #praguelectures

Participate | Dream Biology Award Your dream. Your vision. Biology beyond imagination. Dream Biology Award. A competition for young scientists across biological disciplines who dream of solving fundamental problems with bold ideas.

Applications can be submitted until July 31, 2026 at ► www.dreambiologyaward.org/participate

#DBA #biology #IOCB #IOCBPrague #visionary #vision

🧫 IOCB Prague is launching the first edition of the new international #DreamBiologyAward, a competition organised by @pluskal-lab.org & @dmsabatini.bsky.social that offers young scientists the opportunity to present their ambitious scientific visions in the life sciences.

Read the paper: Dunlop, D.; Strada, R.; Šebej, P. Substituent Effects on Cyanine Dyes Vary with Position and Chain Length. Adv. Optical Mater. 2026, e03219.
doi.org/10.1002/adom...

This new Perspective by David Dunlop from Tomáš Slanina Group and colleagues from @recetox.bsky.social brings order to seemingly conflicting substituent effects and proposes a predictive framework for designing cyanines with targeted optical behaviour and promising new photochemical applications.

🧵🧪 Cyanine dyes are everywhere from bioimaging to diagnostics, but tailoring their properties has not always been straightforward...

🧵

#research #photochem #chemistry #iocb #iocbprague

👉 https://rspkt.cz/300010896 Proč je důležitá popularizace vědy? Nejsou výzkumníci příliš uzavřeni ve svých laboratořích? Dá se spolehnout na AI, když navrhuje různé modifikace molekul?

🇸🇪 Lukáš Janecký, stipendista Nadace Experientia pro rok 2025, má za sebou první půlrok na Stockholm University ve Švédsku, kde vyvíjí speciální borové 3D spojky.

„Tuto zahraniční zkušenost hodnotím jako velice přínosnou,“ říká.

🔬 This tenure-track position is roughly comparable to an #assistantprofessor at a US university or to a #newinvestigator position at Max Planck Institutes in Germany.

See more ► www.uochb.cz/en/open-posi... ⤵️

#openposition #iocbprague #iocb #compchem

📆 Zveme vás na Experientia Day 2026! Letos se potkáme ve čtvrtek 18. června od 10 hodin v budově @iocbprague.bsky.social.

Co jsme pro vás přichystali za program? 🏆🧪

➤ vyhlášení nových stipendistek/stipendistů a držitele/držitelky start-up grantu 1/2

🗣️ We were pleased to host Dr. Hidde Ploegh (Boston Children’s Hospital, MA, USA) with an invited lecture "Nanobodies as tools for biochemistry and immunology" last week.

#praguelectures #IOCBinvitedlecture #chemistry

Jednadvacátý ročník ocenění TOP ženy Česka, které vyhlašují Hospodářské noviny, zná své vítězky a mezi nimi i "TOP ženu veřejné sféry", jíž se stala vědkyně a zakládající členka naší správní rady Zuzana Kečkéšová z @iocbprague.bsky.social.

Jsme hrdí, radujeme se a blahopřejeme! 👏

Substituent Effects on Cyanine Dyes Vary with Position and Chain Length In cyanines, substituent effects vary as a function of substituent position and cyanine length. Electron-donating- and -withdrawing groups at meso- and α-positions of 4n+1/4n−1 long cyanines (n = 1, ...

Read the paper: Dunlop, D.; Strada, R.; Šebej, P. Substituent Effects on Cyanine Dyes Vary with Position and Chain Length. Adv. Optical Mater. 2026, e03219.
doi.org/10.1002/adom...

This new Perspective by David Dunlop from Slanina Group and colleagues from @recetox.bsky.social brings order to seemingly conflicting substituent effects and proposes a predictive framework for designing cyanines with targeted optical behaviour and promising new photochemical applications.

🧪 Cyanine dyes are everywhere from bioimaging to diagnostics, but tailoring their properties has not always been straightforward.

🧵

#research #science #photochemistry #iocb #iocbprague

Read the paper: Brdová et al., J. Viktorová, E. Kudová: Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry 308: 118716, 2026.
doi.org/10.1016/j.ej...

The most active molecules proved non-toxic to human cells and showed no detectable endocrine activity.

Findings support the idea that rationally designed steroid-based molecules could act as antibiotic adjuvants, helping existing drugs overcome resistance.

They inhibited efflux pumps and lowered the effective doses of antibiotics such as ciprofloxacin and erythromycin.

Further analysis showed that one of the compounds also suppressed genes linked to bacterial virulence.

The team screened dozens of natural steroidal hormones and synthetic derivatives to see whether they could block bacterial efflux pumps—mechanisms that bacteria use to eject antibiotics and survive treatment.

2 compounds, labeled 13 and 16, emerged as particularly promising.

🦠 Researchers from IOCB (Eva Kudová) and @vschtpraha.bsky.social (Jitka Viktorová) have identified new androstane-based steroid derivatives that can significantly improve the effectiveness of existing antibiotics against resistant #Staphylococcus. 🧵

#IOCB #IOCBPrague #research #neurosteroids

In addition to the importance of scientific research, representatives of the institute also emphasized the crucial role of translating scientific findings into practical applications. 7/7

Among the commemorative gifts presented was a work of art made of uranium glass.

Along with the senior researchers, our #PhD students also met with the president. 6/7

The program also included a discussion with IOCB staff.

A total of over 100 employees from @iocbprague.bsky.social attended the discussion. 5/7

During the visit, the President toured the laboratories of Hana Cahová and Zuzana Kečkéšová. The former focuses on the chemical biology of nucleic acids, while the latter studies tumor suppressors. 4/7

“We appreciate that the President has taken the time to visit us. Research and education are key to the future and prosperity. At a time when even fundamental scientific facts are often being questioned, meetings like this provide scientists with an extraordinary boost,” said Jan Konvalinka. 3/7

His first stop was IOCB Prague, where he was welcomed by Director Jan Konvalinka during the first-ever presidential visit. 2/7

🇨🇿 #President of the Czech Republic Petr Pavel, accompanied by the President of the @czechacademy.bsky.social Radomír Pánek, visited three scientific institutions on April 1.

1/7

🤝 Trojici ústavů @akademievedcr.bsky.social dnes za doprovodu předsedy AV Radomíra Pánka navštíví prezident republiky Petr Pavel. Jeho první zastávka byla v Ústavu organické chemie a biochemie, kde ho přivítal ředitel ÚOCHB Jan Konvalinka.

#UOCHB #IOCB #IOCBPrague #AVCR #AkademievedCR #ceskaveda

🗣️ We are looking forward to hosting Prof. Hosea M. Nelson (@caltech.edu) with an invited lecture "Electron diffraction for chemical discovery and new reactions of carbocations".

See more ► uochb.cz/en/event-calendar/363

#praguelectures