🦠 Researchers from IOCB (Eva Kudová) and @vschtpraha.bsky.social (Jitka Viktorová) have identified new androstane-based steroid derivatives that can significantly improve the effectiveness of existing antibiotics against resistant #Staphylococcus. 🧵
#IOCB #IOCBPrague #research #neurosteroids
Revolutionary Insights into Brain's Electrical Gates from Cold Spring Harbor Lab #United_States #Cold_Spring_Harbor #NMDA_receptors #neurosteroids
BX’s mechanism in postpartum depression (PPD) involves elevating brain allopregnanolone (AP), which may decrease significantly at postpartum, back to third trimester levels. AP acts as a preferential allosteric modulator and direct activator of extrasynaptic δGABA-ARs, which causes persistent hyperpolarization of neurons and shunts network hyperexcitability. Although the precise binding location is unclear, both activation and potentiation functions of AP apparently proceed from a single interfacial binding site, specifically at the α-subunit lipid interface. AP enhances the receptor function by binding to ‘neurosteroid binding’ sites, which are distinct from sites for GABA and benzodiazepines. Based on their location and kinetics, GABA-ARs are stratified into two groups. Synaptic receptors (α1β2γ2 subunits) mediate phasic inhibition in response to presynaptic release of GABA, while extrasynaptic receptors (α4β2δ subunits) primarily contribute to tonic inhibition in response to ambient
#neurosteroids replacement therapy (NRT) with GABA-A receptor-modulating allopregnanolone (brexanolone) PPD affects 500000 women in 🇺🇸 annually. BX is 1st #neurosteroid approved for PPD and marks a significant milestone in the field of #neuropsychopharmacology
www.cell.com/trends/molec...
MedSky🧪#MolecularMedicine #postpartumdepression is associated with a decline in #progesterone-derived anxiolytic–#antidepressant #neurosteroids after delivery.
