Kaplan–Meier curves for 6-month survival according to treatment group and HIV status.

Tuberculous meningitis is often fatal, and current therapies need to be improved. In the HARVEST phase 3 trial, high-dose rifampin plus standard treatment was assessed. Full trial results: nej.md/49iiDsQ

#MedSky #NeuroSky #IDSky

Did you miss the #IDWeek2025 session on Lassa fever? Check out our recap and more in IDWeek Daily News:
www.pageturnpro.com/JHCLLC/11289...

Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study Olorofim showed efficacy and good tolerability in patients with IFD with few or no treatment options. Further studies will be needed to fully delineate the role of this new antifungal agent.

We need more antifungals, so good to see these new data.

www.thelancet.com/journals/lan...

State-of-the-Art Review: Recurrent Uncomplicated Urinary Tract Infections in Women Abstract. Over 50% of adult women experience at least 1 urinary tract infection (UTI) in their lifetime, and almost one-quarter of them will experience a r

One of the most challenging encounters in the outpatient practice of infectious diseases, summarized here wonderfully in @cidjournal.bsky.social by Drs. Advani and colleagues.
Have already used this algorithm several times!
doi.org/10.1093/cid/...

Fosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS) Fosmanogepix 1000mg IV (loading dose) and 600mg IV or 800mg oral (maintenance dose) was associated with an all-cause mortality of 25% at Day 42 with accept

In CID, Michael R Hodges and colleagues evaluated fosmanogepix (FMGX) treatment in invasive mold diseases (IMDs) by Aspergillus spp. and rare molds in adults with limited treatment options. academic.oup.com/cid/advance-...

Interim Results from STOMP Study of SIGA’s Tecovirimat in Treatment of Mpox Announced Interim analysis shows that tecovirimat did not improve time to lesion resolution compared to placebo in adults with mild to moderate clade II mpoxStudy...

STOMP Study Interim analysis:

- TPOXX (tecovirimat) showed no improvement in lesion resolution time vs placebo in adults with mild-to-moderate clade II mpox
- Enrollment stopped in all study arms
- Strong safety profile
- Efficacy in severe cases not assessed
www.globenewswire.com/news-release...

Donor‐Derived Infections: Transplant Infectious Disease: Vol 26, No S1 Click on the title to browse this issue

So excited to have the Donor-Derived Infection Special Edition out - thanks to Stephanie Pouch and Karen Waller for being guest editors for this special edition!

onlinelibrary.wiley.com/toc/13993062...

We are so excited to welcome our new class of ID Fellows for next year – what an amazing group!!

Maribavir for refractory cytomegalovirus infection (with or without resistance) in solid organ transplant recipients: subgroup analysis of the phase 3 randomized SOLSTICE study - PubMed ClinicalTrials.gov; NCT02931539 DATA AVAILABILITY STATEMENT: The datasets, including the redacted study protocol, redacted statistical analysis plan, and individual participants data supporting the re...

The results of the SOT subgroup analysis of the SOLTICE Phase III RCT (Maribavir vs. IAT) are consistent with those of the overall population. > Effectiveness < Discontinuations. #TxID #IDSky #ViroSky #MedSky pubmed.ncbi.nlm.nih.gov/39613120/

Virtual Home Care for Patients With Acute Illness This cohort study compares outcomes of patients receiving care in an outpatient, virtual, home-based acute care model with outcomes of patients receiving standard hospital care.

For my inaugural post, Im proud to announce the publication of our Safer@Home care model. This is going to change how medicine is practiced. No need to admit pts "for IV antibiotics" anymore. Or just for IV diuresis in CHF. Or just for EtOH withdrawal. Etc.
jamanetwork.com/journals/jam...

On World AIDS Day, let's remember those we've lost, support those living with HIV, and continue the fight for awareness and treatment. ❤️ #WorldAIDSDay2024 #IDSky #HIVSky @idsainfo.bsky.social @hivma.bsky.social

Just a friendly reminder that, in light of the IV fluid shortage, switching to PO antibiotics can be a safe, effective, and patient-centered option! This is because bacteria don't care how the antibiotic gets in.

Take, for example, Gram-negative rod bacteremia!

State-of-the-Art Review: Ocular Infections Collaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review

Latest State-of-the-Art Review in @cidjournal.bsky.social comes from Dr. Miriam Barshak et al on ocular infections.

(I had the pleasure of precepting Miriam in clinic around 20+ years ago --but who's counting! -- and she is brilliant and awesome.) @nottheogdrv.bsky.social
doi.org/10.1093/cid/...

Symptomatic Entamoeba dispar Infections Among Men Who Have Sex With Men, New York City, 2018 Abstract. Entamoeba histolytica is considered the primary species causing the parasitic gastrointestinal infection amebiasis. A cluster of amebiasis infect

Interesting cluster report of symptomatic individuals in NYC presumed from Entamoeba disbar, likely sexually transmitted.

academic.oup.com/ofid/advance...

Excellent thread by @dralicehan.bsky.social on this important paper in @cidjournal.bsky.social.

Dramatic increase in cure with telehealth vs referral to local providers.

Very concerning that telehealth coverage might soon be limited -- it's one of the silver linings of the pandemic.

#IDSky

Coccidioidomycosis Transmission Through Solid Organ Transplantation (2013-2022): A Report of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee - PubMed Despite its rarity, donor-derived Coccidioides infection is a serious concern, particularly due to the high mortality rate in the early post-transplant period. To mitigate these risks, a thorough asse...

#TxID #IDSky #MedMyco
pubmed.ncbi.nlm.nih.gov/39603983/

Serologic screening and molecular surveillance of Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) infections for early recognition and effective treatment of KSHV-associated inflammatory... Kaposi sarcoma herpesvirus/human herpesvirus-8 (HHV-8) neoplastic and non-neoplastic disease in solid organ transplant (SOT) recipients can be life-threatening. We evaluated the seroprevalence of HHV-...

In this single-center retrospective study, @mularoni.bsky.social tested donors (3%) and recipients (8%) for HHV-8. Most of the donor-derived HHV-8-related disease manifested as KICS!! 🤯 On the other hand, most reactivations presented as KS. #TxID #IDSky pubmed.ncbi.nlm.nih.gov/39551265/

Donor-derived Mycoplasma and Ureaplasma infections in Lung Transplant: 18% of donors tested positive. Culture had higher positive predictive value (PPV) compared to PCR.

www.sciencedirect.com/science/arti...

Antibiotic Myths for the Infectious Diseases Clinician

🌟"Today’s teaching point may end up as tomorrow’s myth." 🌟
Dr.Erin McCreary article 👇
#idquotes #idsky #medsky #AMSsky
academic.oup.com/cid/article/...

HIV/AIDS and COVID-19: Shared Lessons from Two Pandemics The HIV/AIDS and COVID-19 pandemics hold important lessons for preparing for, and responding to, future infectious disease outbreaks. Eight lessons common

We will have another pandemic. The question is not if but when. Excellent viewpoint in CID from 2 veterans of #publichealth Anthony Fauci & Greg Folkers. Speakly plainly they hold no punches reflecting on HIV & COVID. We need their wisdom esp now.
A must read! #IDSky
academic.oup.com/cid/advance-...

Don't you just love a good disease primer. Especially for neglected rare diseases we don't see in clinical practice on the daily. This #leprosy primer in nature reviews is great and comes with a snapshot summary that's very digestible.
#IDSky #MedSky
www.nature.com/articles/s41....

A systematic review of 24 randomized trials for #LongCovid
www.bmj.com/content/387/... open-access
No drug, diet, or device intervention has supportive evidence for efficacy. CBT, rehab provided some relief of symptoms (moderate certainty).
We're still in desperate need for a validated treatment!

Rewriting the Script Natasha Spottiswoode, MD DPhil, Daniel J Minter, MD, Rachel Friedman-Moraco, MD; Rewriting the Script, Clinical Infectious Diseases, , ciae589, https://doi

Inaugural article in a new section in @cidjournal.bsky.social called

“Clinical Dilemmas in Infectious Diseases”

led by IDMedEd superstars Daniel Minter and Varun Phadke designed to teach clinical reasoning

Rewriting the Script

academic.oup.com/cid/advance-... #IDSky

Tenets of Infectious Diseases:

1. Source control, source control, source control
2. Stuff sticks to metal (and other material)
3. The drug has to get in to work (GI absorption, tissue penetration, presence of walled-off collection, etc.)
4. Antibiotics should not be anxiolytics

Draft Revised Human Immunodeficiency Virus (HIV) Organ Policy Equity Act Safeguards and Research Criteria for Transplantation of Organs Infected With HIV The HOPE Act requires the Secretary of Health and Human Services (the Secretary) to develop and publish criteria for research involving the transplantation of organs from donors with HIV to recipients...

Additionally, the updated research criteria for HOPE Act transplants are out. You have 15 days to share your thoughts on the revised criteria using the instruction in the notice!

www.federalregister.gov/documents/20...