Immunomodulation in the Treatment of Disseminated Coccidioidomycosis Severe coccidioidomycosis carries high mortality despite antifungals. We treated 18 refractory cases with immune modulation, including augmentation of Type

academic.oup.com/cid/advance-...

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Candida vulturna, the Next Fungal Menace? A Narrative Review Introduction The yeast Candida vulturna is a member of the Candida haemulonii species complex, like its close relative Candida auris. Members of this species complex, including C. vulturna, often di...

Candida vulturna (member of Candida haemulonii species complex)can be misidentified with reduced azole and ampho susceptibilities. #MedMyco #IDSky

Histoplasmosis

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People
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Longitudinal Assessment of the Effect of Invasive Fungal Infections on Transplant Success in Kidney Transplant Recipients Invasive fungal infections (IFIs) significantly impact morbidity and mortality in kidney transplant recipients (KTR), but their effect on allograft fu…

www.sciencedirect.com/science/arti...

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Sensitivity of Coccidioides serologic tests among culture-proven coccidioidomycosis patients with hematological malignancy compared to a matched immunocompetent cohort Abstract. Coccidioidomycosis is associated with an increased risk of mortality and morbidity among immunosuppressed patients. The sensitivity of current co

Coccidioides serology is not very reliable to diagnose coccidioidomycosis in hematological malignancy patients, and that's why antigen test should always be added.
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Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity | Antimicrobial Agents and Chemotherapy Coccidioidomycosis is a fungal infection that is caused by dimorphic, saprobic fungi, Coccidioides species, that are endemic to areas of Arizona, California, New Mexico, Utah, Nevada, and Texas within...

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Olorofim has low MICs in Coccidioides species. Hopefully we will get human clinical data confirming this.

The profound effect of diabetes mellitus control on outcomes of coccidioidomycosis Abstract. Coccidioidomycosis is an endemic fungal infection caused by the soil-dwelling Coccidioides immitis/posadasii. One prior study showed that persons

Increased complications of coccidioidomycosis with uncontrolled DM. "For each 1 unit increase in A1C, the risk of hospitalizations increased by 59% (OR 1.59, p=0.005) and the risk of a cavitary lung lesions increased by 42% (OR 1.42, p=0.01)"
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Impact of fluconazole on outcomes of patients with primary pulmonary coccidioidomycosis: a commercial health insurance claims-based, propensity score matched analysis AbstractBackground. Patients with pulmonary coccidioidomycosis often experience prolonged symptoms lasting weeks to months. Limited data exist regarding wh

Great work by CDC (Mycotic Diseases Branch) and @grthompsonmd.bsky.social. Healthcare data analysis evaluating fluc efficacy on pulmonary #coccidioidomycosis in immunocompetent patients. Again, fluc is not effective.
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Impact of Fluconazole Resistance on the Outcomes of Patients With Candida parapsilosis Bloodstream Infections: A Retrospective Multicenter Study Despite global concerns about fluconazole resistance in Candida parapsilosis, its impact on mortality remains unexplored. Our study found no increased mort

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#IDSky #MedMyco

Emergence of terbinafine-resistant Trichophyton indotineae in Ontario, Canada, 2014–2023 | Journal of Clinical Microbiology Cases of dermatophytosis caused by emerging pathogen Trichophyton indotineae are increasing worldwide. Many are resistant to first-line treatment option terbinafine, resulting in difficult-to-treat ca...

New data on T. indotineae from Canada. We are still far too inactive in addressing these infections!
#Medmyco

journals.asm.org/doi/full/10....

Autochthonous <em>Blastomyces dermatitidis</em>, India Autochthonous <em>Blastomyces dermatitidis</em>, India

Interesting case series of autochthonous B. dermatitidis in India
wwwnc.cdc.gov/eid/article/...

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Coccidioidomycosis Transmission Through Solid Organ Transplantation (2013-2022): A Report of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee - PubMed Despite its rarity, donor-derived Coccidioides infection is a serious concern, particularly due to the high mortality rate in the early post-transplant period. To mitigate these risks, a thorough asse...

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pubmed.ncbi.nlm.nih.gov/39603983/

a man in a red suit and blue tie is holding a piece of paper in his hand . Alt: Will Ferrell as Ron Burgundy raises a conch to his lips and blows on it

#IDSky: Assemble!

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