Rpd3 integrates with transcription factor networks to promote Histoplasma yeast-phase growth under host conditions. Image shows a proposed model for Rpd3 function under host conditions. Rpd3 is required for the repression of hyphal-phase-specific (HPS) genes and the expression of yeast-phase-specific (YPS) genes at 37°C. The study data suggest a model where Rpd3 represses HPS gene expression through the removal of acetyl (Ac) groups on histone H3 (histone), most notably in the promoters of HPS transcription factors (TFs) that may antagonize the Ryp network. The authors hypothesize the genomic landscape established by Rpd3 is indirectly (dashed arrows) required to promote activation of YPS genes through promoting the DNA-binding activity of the Ryp TFs (Ryp1-3). Thus, Rpd3 is required for Histoplasma yeast-phase morphology and virulence gene expression to promote macrophage lysis at 37°C.

#Fungi adapt to temperature during host invasion, but how is this controlled? This study shows that an HDAC-dependent chromatin program enables thermal dimorphism by coordinating activation of pathogenic growth & repression of filamentation in #Histoplasma @plosbiology.org 🧪 plos.io/40D0f9a

Rpd3 integrates with transcription factor networks to promote Histoplasma yeast-phase growth under host conditions. Image shows a proposed model for Rpd3 function under host conditions. Rpd3 is required for the repression of hyphal-phase-specific (HPS) genes and the expression of yeast-phase-specific (YPS) genes at 37°C. The study data suggest a model where Rpd3 represses HPS gene expression through the removal of acetyl (Ac) groups on histone H3 (histone), most notably in the promoters of HPS transcription factors (TFs) that may antagonize the Ryp network. The authors hypothesize the genomic landscape established by Rpd3 is indirectly (dashed arrows) required to promote activation of YPS genes through promoting the DNA-binding activity of the Ryp TFs (Ryp1-3). Thus, Rpd3 is required for Histoplasma yeast-phase morphology and virulence gene expression to promote macrophage lysis at 37°C.

#Fungi adapt to temperature during host invasion, but how is this controlled? This study shows that an HDAC-dependent chromatin program enables thermal dimorphism by coordinating activation of pathogenic growth & repression of filamentation in #Histoplasma @plosbiology.org 🧪 plos.io/40D0f9a

Rpd3 integrates with transcription factor networks to promote Histoplasma yeast-phase growth under host conditions. Image shows a proposed model for Rpd3 function under host conditions. Rpd3 is required for the repression of hyphal-phase-specific (HPS) genes and the expression of yeast-phase-specific (YPS) genes at 37°C. The study data suggest a model where Rpd3 represses HPS gene expression through the removal of acetyl (Ac) groups on histone H3 (histone), most notably in the promoters of HPS transcription factors (TFs) that may antagonize the Ryp network. The authors hypothesize the genomic landscape established by Rpd3 is indirectly (dashed arrows) required to promote activation of YPS genes through promoting the DNA-binding activity of the Ryp TFs (Ryp1-3). Thus, Rpd3 is required for Histoplasma yeast-phase morphology and virulence gene expression to promote macrophage lysis at 37°C.

#Fungi adapt to temperature during host invasion, but how is this controlled? This study shows that an HDAC-dependent chromatin program enables thermal dimorphism by coordinating activation of pathogenic growth & repression of filamentation in #Histoplasma @plosbiology.org 🧪 plos.io/40D0f9a

My favorite collage ever 😎🍄 #Histoplasma

Fungal infection spreads in two TN counties; health officials say MEMPHIS, Tenn. — The Tennessee Department of Health (TDH) reported a fungal infection outbreak spreading in parts of Middle Tennessee, and there are at least 18 known cases currently, accordi…

#Fungal #infection spreads in two #Tennessee counties ...

| #fungi | #pathogen | #histoplasma | #histoplasmosis | #publichealth | Via wreg .com

Left: Example images of colonies from gain-and-loss rate experiments after 12 days at 25°C. Cells derived from an aneuploid parent (top, green) and colonies derived from a euploid parent (bottom, magenta) each showing one progeny colony (indicated by an arrow) that converted in morphology bias. Bar indicates 10 mm. Conversion in morphology bias was used as a proxy for converting in ploidy. Right: Rapid gain and loss of Chr7 aneuploidy may increase phenotypic diversity. Summary scheme of the authors' data, suggesting that rapid gain and loss of the Chr7 aneuploidy may benefit Histoplasma by rapidly increasing phenotypic diversity, helping populations survive frequent and abrupt transitions between environment and host. Histoplasma grows as yeast in the mammalian body and in the laboratory when grown at 37°C, but as hyphae in the environment or in the laboratory when grown at 25°C. Cells with a second copy of chromosome 7 are biased towards hyphal growth and outcompete euploid cells in the yeast-to-hyphal transition (black arrows). Euploid cells (with one copy of each chromosome) are biased towards yeast growth and outcompete in the hyphal to yeast transition (black arrows). Cells frequently gain and lose a second copy of Chr7 (gray arrows). Cells with one copy of Chr7 have increased virulence in comparison to cells with two copies of the chromosome. Cells with two copies of Chr7 have a hyphal-biased transcriptome as do cells with increased copy number of HYF1, a TF on Chr7.

Thermally dimorphic #fungi like #Histoplasma switch between environmental filamentous & host-associated #yeast forms. This study shows that a rapidly reversible duplication of a #chromosome alters the efficiency of this switch, reducing virulence @plosbiology.org 🧪 plos.io/4qCC9Gf

Left: Example images of colonies from gain-and-loss rate experiments after 12 days at 25°C. Cells derived from an aneuploid parent (top, green) and colonies derived from a euploid parent (bottom, magenta) each showing one progeny colony (indicated by an arrow) that converted in morphology bias. Bar indicates 10 mm. Conversion in morphology bias was used as a proxy for converting in ploidy. Right: Rapid gain and loss of Chr7 aneuploidy may increase phenotypic diversity. Summary scheme of the authors' data, suggesting that rapid gain and loss of the Chr7 aneuploidy may benefit Histoplasma by rapidly increasing phenotypic diversity, helping populations survive frequent and abrupt transitions between environment and host. Histoplasma grows as yeast in the mammalian body and in the laboratory when grown at 37°C, but as hyphae in the environment or in the laboratory when grown at 25°C. Cells with a second copy of chromosome 7 are biased towards hyphal growth and outcompete euploid cells in the yeast-to-hyphal transition (black arrows). Euploid cells (with one copy of each chromosome) are biased towards yeast growth and outcompete in the hyphal to yeast transition (black arrows). Cells frequently gain and lose a second copy of Chr7 (gray arrows). Cells with one copy of Chr7 have increased virulence in comparison to cells with two copies of the chromosome. Cells with two copies of Chr7 have a hyphal-biased transcriptome as do cells with increased copy number of HYF1, a TF on Chr7.

Thermally dimorphic #fungi like #Histoplasma switch between environmental filamentous & host-associated #yeast forms. This study shows that a rapidly reversible duplication of a #chromosome alters the efficiency of this switch, reducing virulence @plosbiology.org 🧪 plos.io/4qCC9Gf

Left: Example images of colonies from gain-and-loss rate experiments after 12 days at 25°C. Cells derived from an aneuploid parent (top, green) and colonies derived from a euploid parent (bottom, magenta) each showing one progeny colony (indicated by an arrow) that converted in morphology bias. Bar indicates 10 mm. Conversion in morphology bias was used as a proxy for converting in ploidy. Right: Rapid gain and loss of Chr7 aneuploidy may increase phenotypic diversity. Summary scheme of the authors' data, suggesting that rapid gain and loss of the Chr7 aneuploidy may benefit Histoplasma by rapidly increasing phenotypic diversity, helping populations survive frequent and abrupt transitions between environment and host. Histoplasma grows as yeast in the mammalian body and in the laboratory when grown at 37°C, but as hyphae in the environment or in the laboratory when grown at 25°C. Cells with a second copy of chromosome 7 are biased towards hyphal growth and outcompete euploid cells in the yeast-to-hyphal transition (black arrows). Euploid cells (with one copy of each chromosome) are biased towards yeast growth and outcompete in the hyphal to yeast transition (black arrows). Cells frequently gain and lose a second copy of Chr7 (gray arrows). Cells with one copy of Chr7 have increased virulence in comparison to cells with two copies of the chromosome. Cells with two copies of Chr7 have a hyphal-biased transcriptome as do cells with increased copy number of HYF1, a TF on Chr7.

Thermally dimorphic #fungi like #Histoplasma switch between environmental filamentous & host-associated #yeast forms. This study shows that a rapidly reversible duplication of a #chromosome alters the efficiency of this switch, reducing virulence @plosbiology.org 🧪 plos.io/4qCC9Gf

Oklahoma veterinarian warns pet owners about fungal infection in cats Veterinarian Dr. Rebekah Hartfield warns cat owners about histoplasmosis, a treatable fungal infection found in soil, bird droppings, and bat droppings.

#Veterinarian warns #pet owners about #fungal #infection in #cats ...

| #feline | #fungi | #histoplasmosis | #Histoplasma | #spores | Via newson6 .com

#idsky #idmeded #meded #weareid #IUIDFellowship #histoplasma #serology

📣 New ASSAY ALERT: Quantitative Real-Time PCR Assays for Dimorphic Fungi, Now Available! 🔎 READ: www.eurofins-viracor.com/news-and-eve...

📄 Dimorphic Fungal Brochure: www.eurofins-viracor.com/media/apnosy...

#DimorphicFungal #ViracorFungal #Histoplasma

Testing for Rapid and Accurate Detection of Life-Threatening Dimorphic Fungi | Eurofins Viracor Eurofins Viracor launches rapid qPCR assays for dimorphic fungi, enabling faster, accurate diagnosis and targeted antifungal treatment.

📰 PRESS RELEASE ALERT! 🧪 New quantitative real-time PCR assays for dimorphic fungi, now available. 👇READ NOW 🔎 PRESS RELEASE:
www.eurofins-viracor.com/news-and-eve...

#Blastomyces #Histoplasma #Coccidioides #Cryptococcus #DimorphicFungi #dimorphicfungi

Histoplasmosis

2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults, Children, and Pregnant People
#IDSky #MedMyco #histoplasma

Arterial thrombus caused by #Histoplasma capsulatum deriving from native valve endocarditis caused by the same organism #Idsky

#Histoplasma antigen is a #galactomannan; therefore, it can cross react with #Blastomyces, #Aspergillus, and most other endemic fungi to a lesser extent #PathSky #IDSky #MedSky