The pipeline is openly available and readily extensible to other spinal circuits, motor tasks, and clinical populations
💻 All code: github.com/FrancoisDern...
📊 Data (raw EMG + edited MU spike trains): Figshare
#OpenScience #OpenData #Neuroscience #EMG #Motorneuron #MotorUnit #SpinalCircuit
Key findings:
1️⃣ A validated simulation-based inference pipeline providing probabilistic estimates of recurrent inhibition from observable motor unit spiking features.
2️⃣ Application to six human muscles revealing previously uncharacterized muscle- and intensity-dependent patterns.
🆕 🚩 New preprint on #bioRxiv by F. Dernoncourt .
We introduce a conceptually new framework that combines large-scale human motor unit recordings with simulation-based inference to estimate recurrent inhibition during voluntary contractions in humans.
🔗 Preprint:
www.biorxiv.org/content/10.6...
The CEDE website is now up and running. Designing an experiment using EMG? Then check out this website and try the decision support tool:
cede.isek.org
francoishug.bsky.social et al. investigated non-homogeneous distribution of inhibitory inputs among #motor units in response to #nociceptive stimulation at moderate contraction intensity ⚙️ ✍️
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/JP288504
We combined experimental data + simulation to study how nociceptive stimulation affects motor unit behavior during moderate contractions.
Our findings challenge the traditional view of uniform inhibition and provide new insights into how the nervous system adapts to pain during muscle contraction.
🆕📝 New publication in @jphysiol.bsky.social “Non-homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity”
🔗 doi.org/10.1113/JP28...
@univcotedazur.bsky.social @simonavrillon.bsky.social @agencerecherche.bsky.social
We are recruiting a PhD student to join our team and contribute to research on neuromotor interfaces for motor augmentation and recovery in both healthy individuals and patients.
The application deadline is approaching soon!
amethis.doctorat.org/amethis-clie...
Collab with @francoishug.bsky.social
We are recruiting a postdoc for an exciting multi-disciplinary project that explores the use of quantum sensors to measure muscle behaviour - looking for someone with skills in ultrasound, mocap, and EMG - funded by QLD Government's Quantum 2032 Challenge uq.wd3.myworkdayjobs.com/en-US/uqcare...
📌 The dimensionality of the linear manifold may not directly reflect the dimensionality of descending inputs but could instead relate to the organization of local spinal circuits.
#MotorUnit #EMG #neuroscience #MotorControl #muscle
We combined experimental data and in silico models and showed that the activity of a large sample of motor units from a single hashtag#muscle can be represented by a multidimensional linear manifold; however, these units show very limited flexibility in their recruitment.
🆕 🚩 Check out our latest publication in @jphysiol.bsky.social led by F. Dernoncourt 👨🎓👏: "Flexible control of motor units: Is the multidimensionality of motor unit manifolds a sufficient condition?" - 🔗 urlr.me/x3uVGE @univcotedazur.bsky.social @agencerecherche.bsky.social @simonavrillon.bsky.social
Registration and abstract submission are now open for the CNB Muscle-tendon mechanics across species Satellite meeting in Helsinki Finland July 23rd-26th 2025 before the main ISB meeting.
Meeting website: www.jyu.fi/en/events/mu...
Abstracts due Feb 14th
registration.contio.fi/jyu/Registra...
Finishing the year in style with a job alert! 📢
I am seeking for a talented postdoctoral researcher/researcher to join my Neuromechanics group at UNSW. This is a 2-year full-time position focusing on predictive musculoskeletal simulations (1/3) 👇
🆕 Check out our latest publication in @elife.bsky.social, led by @simonavrillon.bsky.social 👏: "The identification of extensive samples of motor units in human muscles reveals diverse effects of neuromodulatory inputs on the rate coding" 👉 urlr.me/uE8cxG
In my group, we focus on understanding the neural control of movement at the spinal motor neuron level, combining experimental and computational approaches. We combine high-density surface #EMG and blind source separation algorithms to decode motor neuron firing activity non-invasively.
