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Posts by Argyris Zardilis

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How can we learn tissue mechanics directly from cell patterns and images?

In our new preprint, we introduce VertAX, a differentiable vertex-model framework in JAX for simulating epithelia, inferring parameters, and designing target tissue behaviors.

shorturl.at/PUzT0
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1 week ago 48 22 2 0
Postdoc Pönisch Lab Postdoc Pönisch Lab

Interested in stochastic tissue morphodynamics in development and disease? Join us at HT @humantechnopole.bsky.social

We are recruiting a postdoc for a project combining image analysis, morphometrics, and modelling in collaboration with experimentalists.

More information:
tinyurl.com/3kc7s4rz

5 days ago 4 5 0 0
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New #Sci #Job ! Together with six other PI’s based at the Universities of Tübingen - Heidelberg - Hohenheim and the Max Planck Institute for Biology in Tübingen, we are looking for two PhD students and a Postdoc for our LEAP project, which is part of the Cluster of Excellence @greenrobust.de

1 month ago 8 11 1 0
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Gene regulatory networks: from correlative models to causal explanations Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"

Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?

rdcu.be/e7zx7

1 month ago 121 46 2 2
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📢We are excited to announce the Cambridge Morphogenesis Symposium - a full day event at SLCU @slcuplants.bsky.social (and virtually) on 5 June 2026!
🎉Come celebrate the 5th anniversary of the seminar series!
🚩Register & submit abstracts by 3 April! Check out the details: t.ly/YYM3u
Please repost!🙏

1 month ago 24 20 1 3
Sainsbury Laboratory Symposium 2026 logo - Shaping Life-Mechanisms of Morphogenesis. Timelapse of a developing Arabidopsis leaf imaged at 9-12 days old under a confocal microscope, with cells segmented and coloured using MorphographX software. Images by Sarah Attrill.

Sainsbury Laboratory Symposium 2026 logo - Shaping Life-Mechanisms of Morphogenesis. Timelapse of a developing Arabidopsis leaf imaged at 9-12 days old under a confocal microscope, with cells segmented and coloured using MorphographX software. Images by Sarah Attrill.

Registrations now open for #SLS26 Sainsbury Laboratory Symposium 2026 in Cambridge, UK — Shaping Life: Mechanisms of Morphogenesis!
Join us explore how cellular, genetic & mechanical forces sculpt plant form
📅 22–24 Sept 2026
In-person + livestream
Limited fee waivers
www.slcu.cam.ac.uk/sls
#plantsi

2 months ago 40 28 0 4
Portail Emploi CNRS - Offre d'emploi - PhD (M/F) in development of machine learning methods for single-cell omics data integration Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

PhD position in my team at @pasteur.fr ! The selected canddiate will work on the development of new methods combining biophysicial and machine learning modelling for single-cell multi-omics spatiotemporal data.

emploi.cnrs.fr/Offres/Docto...

2 months ago 10 12 1 0
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The Cambridge Morphogenesis Seminar Series is back! 🎉
Check out the flyer for a great lineup of speakers for Lent Term 2026!
Don't forget to subscribe to our mailing list to get all the information, including the Zoom link. We are excited to see you again soon 👋

3 months ago 15 8 1 2
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We have an open PhD position here in Marseille - please spread the word :)
Deadline for application is 28th of January!

3 months ago 6 4 0 1
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The new ShapeEmbed deep learning method helps quantify shapes in bioimages 🔬

It learns to encode 2D object outlines into descriptors that are invariant to several geometric transformations.

Great for robust cell shape analysis, classification & exploring phenotypes.

neurips.cc/virtual/2025...

4 months ago 16 4 1 0
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Investigating morphogen and patterning dynamics with optogenetic control of morphogen production Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control of morphogen production in vitro. Using light-controlled Sonic hedgehog expression, they recapitulate neural tube...

Good to see the peer reviewed version of this published

A chemo-optogenetic system for spatiotemporal control of gene expression

We use it to:

- Reconstruct SHH mediated neural tube patterning in vitro

- Measure extracellular half-life of Shh

www.cell.com/developmenta...

4 months ago 71 24 3 0

Interested in doing an interdisciplinary PhD to elucidate signalling centres that orchestrates limb regeneration? Come to work with the amazing @canaztekin.bsky.social and myself!!

4 months ago 3 2 0 0

Congratulations Elise Laruelle & @robinsonsci.bsky.social on your @acceleratescience.bsky.social - @c2d3.cam.ac.uk funded project "Plant automatic cell lineage reconstruction"
More info www.slcu.cam.ac.uk/news/plant-a...
Illustration by Elise Laruelle & leaf images by @sainikumud.bsky.social

4 months ago 21 8 0 1
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Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...

Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.

Paper: www.nature.com/articles/s41...

5 months ago 48 25 1 4
advert text as bitmap

advert text as bitmap

picture of the Schornacklab team

picture of the Schornacklab team

Plz RP. Come join us at @slcuplants.bsky.social @cam.ac.uk to study effector-targeted plant processes impacting plant cell biology and development.
www.cam.ac.uk/jobs/post-do...
www.schornacklab.net

5 months ago 33 38 0 1
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How can we organize current theoretical approaches for developmental biology - from information to dynamical systems & GRNs - into a common framework?

We propose to think along Marr's 3 levels: computational problem, algorithm, implementation

Check out our review:
arxiv.org/abs/2510.24536

5 months ago 49 13 1 2
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The Cambridge Morphogenesis Seminar Series is back this Michaelmas Term 2025!
Join us for an exciting lineup of talks exploring the many facets of tissue morphogenesis. Check out the flyer for the full list of speakers!

6 months ago 9 4 1 0
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CBIAS2025 flier, showing the conference logo, listing the topics, confirmed speakers and sponsors. On the top right corner, a QR code is available to access the registration page.

CBIAS2025 flier, showing the conference logo, listing the topics, confirmed speakers and sponsors. On the top right corner, a QR code is available to access the registration page.

The program for the #CBIAS2025 is now live – space is limited, so register now to secure your spot! 24th-25th Nov, Wellcome Trust, London (UK) - see you there!

🔗⬇️
www.crick.ac.uk/whats-on/cri...

6 months ago 10 7 0 0

New preprint!
"Understanding Shape and Residual Stress Dynamics in Rod-Like Plant Organs" 🌱
with @merozlab.bsky.social and @routierlab.bsky.social
👉 doi.org/10.1101/2025...

7 months ago 14 6 1 0
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The BM^2 Lab is hiring a Ph.D. student to work on a variety of problems connected to modeling of morphogenesis in plants (i.e. ovule curvature formation, fixed handedness establishment in certain plant organs and its link to cell wall mechanics).

Please share!

7 months ago 34 39 1 2
Group photo of workshop attendees standing in ginkgo tree courtyard with the Sainsbury Laboratory Cambridge University building in background.

Group photo of workshop attendees standing in ginkgo tree courtyard with the Sainsbury Laboratory Cambridge University building in background.

🌿💻 Plant Models and Morphology 💻🌿

The 9th International Plant Computational Biology Workshop @slcuplants.bsky.social brought together mathematicians, computer scientists, physicists and biologists exploring plant development through models and simulations.

Huge thanks to organisers and speakers!👏

7 months ago 18 4 1 0
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Very happy to share MODIS - a new Multi-Omics Data Integration method for Small and unpaired datasets!

We solve a long-standing problem in the field: how to perform data integration for small unpaired datasets

Our solution: learning with class imbalance on both reference and target datasets!

7 months ago 13 2 1 0

Amazing illustration @nickdesnoyer.bsky.social 🌺!
I wish we had something like this to illustrate the dynamics of our model!

Paper (including model, not animated sadly!)
➡️ doi.org/10.1126/scia...

7 months ago 3 0 0 0
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Home - RESYDE: Re-engineering symmetry breaking in development and evolution. A consortia of plant scientists from Europe and Australia has been awarded a prestigious research grant from the ERC, which will ...

Come and work with us!
We are hiring a research assistant/associate @slcuplants.bsky.social to work on the RESYDE project (www2.hu-berlin.de/resyde/)
using ML for multi-scale data and modelling to understand and engineer flower development!

Details: www.jobs.cam.ac.uk/job/52116/

8 months ago 7 5 0 0
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It was very nice to attend and present at #LMRL @iclr-conf.bsky.social !

Our paper with my student Sasha Budnikova @slcuplants.bsky.social on learning mechanical models (Lockhart) from data!
openreview.net/forum?id=yQF...

11 months ago 1 0 0 0

Looking forward to this! Join us!

1 year ago 1 0 0 0
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A computational pipeline for spatial mechano-transcriptomics - Nature Methods The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

🚨 Paper Alert 🚨
Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" @naturemethods👇!!
www.nature.com/articles/s41...

1 year ago 139 53 10 3
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We were delighted to host @zardilis.bsky.social from Cambridge's Sainsbury Laboratory during the past two weeks! It was a fantastic opportunity to exchange ideas on the spatial biology of plants and beyond. Interesting new methods combining expression patterns, morphometric and physical features!!

1 year ago 9 3 1 0

Thanks Paul! Back in Cambridge full of ideas!

1 year ago 1 0 0 0