Thanks to all co-authors, reviewers, editors, and critical support from @rockefeller.edu, Center for Integrated Cellular Analysis @cegs-ica.bsky.social, The Mathers Foundation, the Melanoma Research Alliance @melanomaresearch.bsky.social, and NIH!!

Excited to share our new paper @nature.com! We developed PerturbFate, a scalable single-cell platform to discover how diverse genetic perturbations converge on a shared drug-resistant cell state, and key programs driving it, led by our incredible Zihan Xu from @rockefeller.edu
rdcu.be/fdC14

A @nature.com study from Rockefeller's @junyuecao.bsky.social describes a new platform called PerturbFate that reveals how diverse genetic perturbations funnel into shared disease states, a method that could unlock therapeutic targets for complex diseases.

🔗: https://bit.ly/4thIsRw

Honored to be part of the Schmidt Science Fellows family! Excited for this pivot to bring discoveries to real-world impact, and deeply grateful to my mentor @junyuecao.bsky.social, labmates, collaborators for their unwavering support, and @rockefeller.edu for an exceptional training environment!

Please explore the full dataset on our website: epiage.net

Thanks to all co-authors, reviewers, editors, and support from @rockefeller.edu, Center for Integrated Cellular Analysis @cegs-ica.bsky.social, @afar.org, impetus grants and NIH!!

New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in @science.org, led by our fantastic graduate student Ziyu Lu from @rockefeller.edu!
www.science.org/doi/10.1126/...

Rockefeller's @junyuecao.bsky.social has created the most comprehensive atlas yet of how #aging affects thousands of cell subtypes. By profiling ~7 million individual cells, his lab has found which cells are most vulnerable to aging and what drives their decline: https://bit.ly/4bh9cdd

Lineage recording in monoclonal gastruloids reveals heritable modes of early development Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...

New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

Excited to share our first anti-aging intervention analysis, led by brilliant Zehao @tommyz626.bsky.social, Alex, and Chloe from our lab at @rockefelleruniv.bsky.social! We identified the aging-associated cell populations that can be rescued by caloric restriction in the mammalian brain!

Hero lawyers in state AG offices busted their asses over the weekend to get this done. Now do your part: call your Representative and Senators TODAY. Call your AG AND governor and voice your support for these lawsuits.

Multiplex generation and single-cell analysis of structural variants in mammalian genomes Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.

www.science.org/doi/10.1126/...

Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!

Study reveals how unexpected shifts in cell populations are revising our understanding of the aging process - News A newly created atlas of 21 million cells could provide fresh directions for anti-aging therapies.

A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience

Thanks Gonçalo!

Thanks Tim!

Thanks Vivek!

Thanks Kueh!

Thanks Yapeng!

Thanks Dingyao!

Thanks Jacob!

Thanks Vijay!

A panoramic view of cell population dynamics in mammalian aging To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

Pretty cool!

Also interested in T cells - please add me as well : )