Thanks for recapping the most intriguing #RockefellerScience stories of 2025 with us, Happy New Year! 👩🏽🔬 🥂 🦠 🎉 🧬
See the full 2025 #YearInReview here: https://bit.ly/44LtGrW
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Scientists in the @alushinlab.bsky.social figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview
🔗: https://bit.ly/3PKErmA
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A study from @danmucida.bsky.social and @victora.bsky.social showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of #foodallergies. #RockefellerScience #YearInReview
🔗: https://bit.ly/4hyS18b
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A study from the #RutaLab explained how the fruit fly brain coordinates courtship and aggressive competition—a framework which could help scientists understand how the human brain balances cooperation and competition. #RockefellerScience #YearInReview
🔗: https://bit.ly/4gI7phV
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A study from Erich Jarvis and @darnelr.bsky.social found that a single protein variant found only in humans may have helped shape the emergence of spoken language. When put in mice, the variant altered their vocalizations. #RockefellerScience #YearInReview
🔗: https://bit.ly/3Yfdcoh
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A study from the #FriedmanLab identified a neural mechanism involved in leptin resistance, a factor contributing to #obesity. Crucially, they also found a way to reverse it in mice using a well-known drug. #RockefellerScience #YearInReview
🔗: https://bit.ly/3MV0WqC
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Clinical trials based on work from the Nussenzweig lab showed that two broadly neutralizing antibodies can keep #HIV suppressed for months. The data suggest that the antibodies may even diminish the viral reservoir itself. #RockefellerScience #YearInReview
🔗: https://bit.ly/4pkY045
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A new method from @hirofunabiki.bsky.social dramatically improved cryo-EM’s imaging capabilities, enabling visualization of molecules that are very rare, very small, or hard to produce naturally—including some viruses. #RockefellerScience #YearInReview
🔗: https://bit.ly/4awR4gv
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The #StricklandLab discovered that amyloid-beta (Aβ) oligomers and the vascular protein fibrinogen may, when forming a complex, contribute to Alzheimer's disease. #RockefellerScience #YearInReview
🔗: https://bit.ly/44Eh31R
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The #StellerLab found that boosting PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to Parkinson’s. #RockefellerScience #YearInReview
🔗: https://bit.ly/3MOlmSc
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Research from the Fuchs lab showed that low levels of the amino acid serine trigger a process that turns hair follicle stem cells into skin repair specialists—and that diet may have a role to play. #RockefellerScience #YearInReview
🔗: https://bit.ly/4jfd9CA
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Rockefeller's Li Zhao spent nearly a decade cataloguing evolutionarily young genes. This year, her lab demonstrated how these new genes are regulated and expressed. #RockefellerScience #YearInReview
🔗: https://bit.ly/4jdvwb8
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Treatments for autoimmune diseases have big shortcomings, including high cost and supply shortages. A alternative developed this year from the #RavetchLab achieves the same effectiveness at a fraction of the dose. #RockefellerScience #YearInReview
🔗: https://bit.ly/3HFdsbs
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A study from the Birsoy lab showed that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung. #RockefellerScience #YearInReview
🔗: https://bit.ly/44GfOPG
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Shortly before his death this year, James Hudspeth achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience #YearInReview
🔗: https://bit.ly/49oaOlo
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The #BradyLab identified compounds that appear effective against drug-resistant bacteria using a new technique that could uncover many more antibiotics, as well as help illuminate a previously hidden microbial world. #RockefellerScience #YearInReview
🔗: https://bit.ly/4sjhV6j
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The first detailed look at how mosquitoes mate from the Vosshall lab reversed the assumption that male mosquitoes control the process, finding that a subtle female behavior dictates if mating will take place or not. #RockefellerScience #YearInReview
🔗: https://bit.ly/4huwEpL
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Neuroscientists have long posited that #memory functions like an on/off switch—either your brain remembers something or it doesn’t. The #RajasethupathyLab discovered that the truth is more complicated. #RockefellerScience #YearInReview
🔗: https://bit.ly/3MoSsrj
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The #WalzLab revealed key details about the T cell receptor, which is essential to T cell immunotherapies. The findings could expand T cell therapies, bringing their benefits to a broader group of #cancer patients. #RockefellerScience #YearInReview
🔗: https://bit.ly/3L0r3vK
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Winter break is upon us! Stay tuned as we count down the most intriguing #RockefellerScience stories of 2025. #YearInReview
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In a new @cp-cellstemcell.bsky.social study, scientists in the Brivanlou lab have used light-inducible gene expression to demonstrate that the formation of the body axes in human embryo models requires an interplay between chemical cues and mechanical forces. #RockefellerScience
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A new study in ants from @danielkronauer.bsky.social reveals a previously unknown mechanism that ensures that each olfactory neuron expresses only one odorant receptor, with broad implications for the study of gene regulation. #RockefellerScience
https://bit.ly/4pwPFLY
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A study from the #StellerLab in @pnas.org finds that boosting PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to Parkinson’s. #RockefellerScience
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Now out in @natbiotech.nature.com: Newly identified compounds from the #BradyLab appear effective against drug-resistant bacteria. The technique used to reveal them could uncover many more antibiotics, as well as help illuminate a previously hidden microbial world. #RockefellerScience
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Shortly before his death last month, James Hudspeth and his team achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience
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A new study from the #BirsoyLab shows that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung. #RockefellerScience
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Published in @cp-cancercell.bsky.social, the #RavetchLab demonstrates in a phase 1 clinical trial that an engineered antibody improves a class of cancer drugs—called CD40 agonist antibodies—that has struggled to make good on its early promise. #RockefellerScience
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A new tool from the #BradyLab that helps predict antibiotic resistance could help pharmaceutical companies design longer lasting drugs. #RockefellerScience @pnas.org
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New research from @danielkronauer.bsky.social's lab in @pnas.org sheds light on how a young ant’s future is determined by genetics and the environment, finding that genes not only influence size, they change what a given size means for the colony. #RockefellerScience
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Scientists in the #HeintzLab discovered an identical neural circuit that operates differently in male and female mice. #RockefellerScience
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