The #StellerLab found that boosting PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to Parkinson’s. #RockefellerScience #YearInReview

🔗: https://bit.ly/3MOlmSc

PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism | PNAS Neurodegenerative diseases present one of the most significant global health challenges. These disorders are defined by the accumulation of abnorma...

Study by #StellerLab @rockefelleruniv.bsky.social demos that boosting levels of the protein PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to #Parkinsons. PNAS
www.pnas.org/doi/10.1073/...

Increasing the level of the protein PI31 demonstrates neuroprotective effects in mice - News One fundamental feature of neurodegenerative diseases is a breakdown in communication. Even before brain cells die, the delicate machinery that keeps neurons in touch—by clearing away protein waste at...

A study from the #StellerLab in @pnas.org finds that boosting PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to Parkinson’s. #RockefellerScience