Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇
📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬
"How cells copy their epigenome"
Register until Oct 31! 👇
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
Image credit: @gloglita.bsky.social @lifescienceeditors.bsky.social captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes
🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)
Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
Latest #CDlab paper online now:
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...
This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social) and single-molecule data (Richard Janissen).
Please join us celebrate the 5th year birthday of Social DNAing! Dr. Chapman will take the stage in the coming week. Sign up at cancer.columbia.edu/research/progr…
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?
Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!!
Please distribute :) 🙂
Amazing accomplishment 👏👏 congrats Hiten and team 🎉
Excellent advice!!
From theory to practice — explore #computational approaches and #AI developments at EMBO Practical Course "Integrative modelling of biomolecular interactions" in Izmir, Türkiye, 28 September–3 October 2025
Deadline: 15 June
meetings.embo.org/event/25-bio...
#EMBObiomolInteractions #EMBOevents 🧪
Congratulations 🎉
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
⏰🚨FINAL DEADLINE APPROACHING
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
📢 Next speaker in our '3D Regulatory Genome' series: Dr. Alvaro Rada Iglesias (@radaiglesiaslab.bsky.social) presenting innovative enhancer research using transgenic mouse stem cells!
Moderated by @stefanschoenfelder.bsky.social
Register: us02web.zoom.us/webinar/regi...
#Genomics #VirtualSeminar
One more appointment with great science in a few days, one click away 👇
💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network.
bit.ly/3EGflmL
Get to know Tuncay Baubec, former EMBO Young Investigator and EMBO Postdoctoral Fellow, who studied in #Austria, started his own group at University of Zurich and is now Professor at @utrechtuniversity.bsky.social: www.embo.org/people/the-f... 🧪 #LifeSciences #research #opportunities
Exciting science ahead! Hope to see many of you online on Tuesday 6th (just connect, no registration needed)
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism
Peter Andersen @germline.bsky.social and collaborators
www.embopress.org/doi/full/10....
Co-organized by EMBL, EMBO and EMBO Press, the EMBL Science and Society Conference "In science we trust?" will explore the importance of public trust in science and the role we all play in shaping its future. 🧪 Register by 5 May: www.embl.org/about/info/c... #LifeSciences @embl.org @embopress.org
Hana Polasek-Sedlackova
Cell scientist to watch – Hana Polasek-Sedlackova @hanasedlackova.bsky.social
In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby.
journals.biologists.com/jcs/article/...
To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴
www.biochemistry.org/events-and-t...
Dr Peter Marks, "Vaccines have been studied very extensively for being potentially associated with autism"
"That theory has been debunked"
"One study in Denmark, over 600,000 children. It shows that if anything, children had a lower rate of autism than unvaccinated children"
This is really great. Congratulations to @guijacquemet.bsky.social and all authors.
#PaperThemeTune can be anything from the atypical album Milijard by Circle, who are Finnish and also really great.
