Check out our new release on BioRxiv
co-lead by @pm-mueller.bsky.social

👉 rb.gy/lnrizk

special🙏 to
Severine Kunz #MDC
@leventallab.bsky.social
@andimicroscopy.bsky.social
@ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM

Are the days of discovering new cellular structures over?? /1

Mammalian membranes are thought to universally avoid macroscopic solidification, as reduced fluidity impairs plasticity and protein function. Cells counter this via lipid unsaturation and cholesterol buffering.
However, the ER is deliberately cholesterol-poor to maintain high-curvature membranes!/5

Here is someting unexpected definitely worth to be highlighted on a #FluorescentFriday. @oliverrocks.bsky.social shows that unmixing of saturated lipids generates fascinating, super rigid tubules in the ER. This work gives new insight in how the cell may regulate sheet vs. tubular ER domains.

A stab at the brain: #Astrocytes (GFAP – cyan) and #microglia (Iba1 – magenta) took care of the damage and isolated the wound from the surrounding tissue. Normal distribution of neuronal NeuN (yellow) indicates the efficiency of the #glia based damage control. #FluorescenceFriday

Missed the symposium deadline over Easter? Good news! The Call for Symposia for GLIA 2027 has been extended by 12 days. New deadline: 20 April 2026. Submit Symposia, Trainee, or Technical proposals: https://www.glia-meeting.eu/2027/call-for-symposia/

A high-affinity split-HaloTag for live-cell protein labeling Nature Communications - Lin and colleagues present high-affinity split-HaloTag pairs for protein tagging and multiplexed labelling. This versatile system allows protein visualisation with diverse...

A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...

With the deadline for abstract submission approaching, it is our pleasure to introduce the first invited speaker of #AstrocyteCafe2026😍

@aleksandrapekowska.bsky.social , we can't wait to hear more about your latest research!!!

We're still accepting submissions for our upcoming special issue - Imaging Cell Architecture and Dynamics - which is being coordinated by @franbottanelli.bsky.social and Giulia Zanetti, working alongside our Editor @guijacquemet.bsky.social
Deadline: 1 April
journals.biologists.com/jcs/pages/im...

Podosomes in endocytosis! 🔬

Check out our new preprint "Drebrin forms a cortical hub that connects actin, microtubules, and clathrin for endocytic transport of β2 integrin"
www.biorxiv.org/content/10.6...

I would use such a AI slob as boomerang to disqualify that reviewer in return

BEYOND BOUNDARIES - MOVING FORWARD TOGETHER: Wir feiern weitere sieben Jahre Exzellenzförderung!

🎉BREAKING: Die #BerlinUAlliance schreibt Geschichte und wird als erster Verbund für weitere sieben Jahre im Rahmen der #Exzellenzstrategie von Bund und Ländern gefördert! 👉 Mehr erfahren: www.berlin-university-alliance.de/items/2026/2...

Congratulations, Shashank! Well deserved.

Newest advancement in German train technology: Stealth S-Bahn (Overground) train in Berlin. According to the @deutschebahn.com announcement, the train stands here ready for departure, but I cannot see it, although I am supposedly standing right in front of it...

Postdoc job alert in the Crick Institute in London. Are you interested in the actin cytoskeleton? I am looking for a postdoc to examine the cellular, developmental or physiological role of Arp2/3 iso-complex driven actin polymerisation. Multiple aspects available.
crick.ac.uk/WayPostdoc2026

2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

FÖRDERENTSCHEIDUNGEN und TERMINE 2026 25.-26.03. Senat / Hauptausschuss 27.03. neue / verlängerte Forschungsgruppen 27.03. neue Schwerpunktprogramme SPP 15.05. neue / verlängerte SFB 01.06. neue / verlängerte Graduiertenkollegs 29.06.-01.07. DFG-Jahresversammlung in Bonn 29.-30.06. Senat / Hauptausschuss 01.07. neue / verlängerte Forschungsgruppen 01.07. DFG-Jahresbericht 2025 16.-17.09. Senat / Hauptausschuss 18.09. neue / verlängerte Forschungsgruppen 16.11. neue / verlängerte Graduiertenkollegs 26.11. neue / verlängerte SFB 09.-10.12. Senat / Hauptausschuss 10.12. Forschungsimpulse FIP 11.12. neue / verlängerte Forschungsgruppen

Termine! 📅 2026 tagen die DFG-Gremien turnusmäßig wieder 4 Mal – und beraten sich über Anträge in der Einzelförderung, von Forschungsgruppen und andere Entscheidungsvorlagen. Die Ausschüsse der Graduiertenkollegs (GRK) und Sonderforschungsbereichen (SFB) kommen an gesonderten Terminen zusammen.

20-plex volumetric super-resolution imaging of cellular ultrastructure. Preprint, led by @seweryn-galecki.bsky.social, dropping soon.

In parallel, we'll be publishing a special issue on Imaging Cell Architecture and Dynamics - you can find out more at:
journals.biologists.com/jcs/pages/im...

Submission deadline: 1 April 2026

#imaging #microscopy #cellbiology

The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...

Great study in @natneuro.nature.com revealing reactive astrocyte-specific enhancers by @margheritazamboni.bsky.social et al (@ellorens.bsky.social, @ki.se) + it brings along a neat AAV to target reactive astrocytes => definitely one tool that we want to try out www.nature.com/articles/s41...

Are you interested in cytoskeleton and looking for a postdoc position? I will be advertising positions in the new year but happy to chat in person if you are attending ASCB @ascbiology.bsky.social in Philadelphia. Just drop me a line.

Introducing mScarlet3-S2: a highly photostable and bright red fluorescent protein.

www.nature.com/articles/s41...

From aerospace to neuroscience: new imaging tech captures the brain’s intricate connections Inspired by technologies used in aerospace engineering, scientists have developed a way to capture the brain’s intricate structures using X-rays without destroying the samples.

Researchers at the Crick, @psich.bsky.social and @esrf.fr have developed a new way to look deeper into brain cell connections by using a particle accelerator and a kind of resin borrowed from the aerospace industry.
www.crick.ac.uk/news/2025-11...

Very cool indeed!

Tomorrow we will celebrate the 10th Anniversary of our AMBIO Imaging Facility. I am very much to see a lot of cutting edge microscopy data.

Check out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish."

lnkd.in/gN7z6th4

Macrophages are super!
SoRA (superresolution after optical reassignment) microscopy video of a primary human macrophage transfected with Lifeact-GFP to visualize actin-rich podosomes.
Star-like appearance is due to connecting cables linking individual podosomes into a cell-wide superstructure ✨

Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

A fantastic paper by my @hhmijanelia.bsky.social colleague and friend Heejun Choi (who is on the job market!). Another elegant use of the Janelia Fluor dyes for cellular imaging. www.nature.com/articles/s41...

What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.

This study reflects the dedication of a great team over many years. I am sincerely thankful to my co-first author Tom Bickel, to our PI Christian Madry and to all collaborators who brought their expertise and care to this work.

Read the full story here: www.science.org/doi/10.1126/...