Me today watching @nataliagonzalezp.bsky.social leave lab for the last time. Natalia is an outstanding scientist and is going to do great things at @mpfneuro.bsky.social!

As a recipient of federal grants from #NIH (for now! 😭) that funds research in my lab, I'd like to sincerely thank American taxpayers on #TaxDay for investing in scientific research that lays the foundation for medical and technological innovation in this country and keeps us ALL safe and healthy

👑

Pathways to pain: graphic illustrating the symptoms and mechanisms of endometriosis. Panel 1: diagram of the pelvic area showing common locations of lesions and cysts: the abdominal wall, the peritoneal membrane, the ovaries, between the uterus and rectum, and the vagina. Panel 2: Illustration of a reproductive system with endometriosis, showing locations of lesions and an ovarian cyst, as well as menstrual blood flowing out of the fallopian tube, which is thought to seed lesions. Panel 3: comparison of neutrophils in the menstrual effluent (ME) of women with endometriosis versus without; with endometriosis, the neutrophils have shrunken, many-lobed nuclei and vacuoles in their cytoplasm. Panel 4: Illustration of immune factors involved in endometriosis lesions: decreased natural killer cells, and increased neutrophils and macrophages.

A scientist is helping uncover the role of the immune system in endometriosis—while managing the disease herself.

Learn more on #WorldHealthDay: https://scim.ag/4oDvjAa

First #FluorescenceFriday post! Some islands in the human NAc 🏝️🧠. Forever fascinated with this really cool population. Shoutout to @svitlanabach.bsky.social for the incredible Visium-HD targeting!

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding Goode et al. show that prodynorphin (Pdyn)-expressing neurons of the dorsolateral septum (DLS) receive substantial dorsal hippocampal (DHPC) input and inhibit lateral hypothalamic (LHA) GABAergic neur...

Restaurants, billboards, commercials… what brain circuits link context to appetite? 🧠🌎🍽️

Very happy to finally share a major update in our work exploring the hippocampus and lateral septum in calibrating food consumption! 🍩

Major thanks to our lab and collaborators! ⭐️⭐️

www.cell.com/neuron/fullt...

FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)

Excited to share our study in Neuron led by
@travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications

🐐

Great feeling for a friday. First cell from the new rig. Still a lot of work to do on the rig, but we are patching. Feels like going back to your first love ❤️ 😍

New paper out on cortistatin neurons and their role in regulating fear and cortical hyperexcitability in the prelimbic cortex! This one has been a fun ride 🧵 www.biorxiv.org/content/10.6...

Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus The ventromedial hypothalamus (VMH) and arcuate (ARC) nuclei of the hypothalamus play critical roles in regulating metabolism and behavior. Here, Mulvey et al. create a focused spatial transcriptomic ...

Now online! @lieberinstitute.bsky.social & @jhubiostat.bsky.social collaboration generating important resource (Visium & Xenium) on molecular organization of human hypothalamus w/ cool findings associating sex differential expression to neuropsychiatric disorders 🧠🔬🧪
www.cell.com/cell-reports...

U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office A Science analysis reveals how many were fired, retired, or quit across 14 agencies

This quantification of loss is staggering. And knowing some of the excellent people that make up these numbers… is heartbreaking
www.science.org/content/arti...

Cartoon zebrafish with green lit-up brain, in well of plate responding to hit molecule.

Drug discovery for nervous system disorders is really challenging. We think early/rapid in vivo testing with zebrafish will accelerate the drug development cycle for conserved targets. Check out our proof-of-principle pilot study and virtual drug discovery pipeline (tinyurl.com/3whr23hs). #Skytorial

#ACNP2026 was a huge success! Great location, with even better science.

Americans still have more confidence in scientists than many other groups in society

Full survey results show American public have high levels of confidence in scientists while revealing some partisan differences (including on how to fund science), but statements asserting lost trust should be read instead as intentional efforts to degrade trust.

www.pewresearch.org/science/2026...

Natalia is awesome! She’s applying to grad schools this fall and will make a great addition to any lab

Excited to be headed to my first @acnporg.bsky.social meeting! Stop by my talk to hear about D1-islands in the human NAc or my poster to hear about our efforts to use spatial transcriptomics to profile lateral septum neurons in the human brain.

Keri is not only an incredible scientist, but also an awesome mentor. So excited to see what's next for LIBD with @martinowk.bsky.social as CSO #Chief

Steve claims not to have thrown a snowball in Brad's "Annoying little face". The evidence suggests otherwise.....

Incredibly excited to and truly honored to receive a #SOBP travel award! Grateful for the opportunity and excited to attend the meeting, share my work, and connect with a new group of scientists. Looking forward to an awesome experience #SOBP2026

🧠🐭💊 Check out our work on the role of Central Amygdala cell-types in opioid withdrawal ...

Now published in Neuropsychopharmacology
@npp-journal.bsky.social

Open-access link: www.nature.com/articles/s41...

Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT) The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...

Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention.

1/7

www.biorxiv.org/content/10.6...

Also! @rehg-j.bsky.social is the talent behind the 🔬for some of my most loved #FluorescenceFriday images! He is an amazingly talented RA that is applying to grad school this cycle and has done an incredible job contributing to this project over the past two years!

Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting Parenting behavior emerges from hormonally sensitive circuits, but how distinct circuit components are affected by, and contribute to, sex and state dependent changes in infant caregiving remains uncl...

New paper alert!!...🤩 Led by @blogeman.bsky.social, we identify how cell type-specific hormonal responses in the hypothalamus tunes parenting behavior in males and females 🐭🧠🍼. Highlights in thread 👇 1/6

www.biorxiv.org/content/10.6...

Viral labeling of projection neurons in the mouse brain with green fluorescence protein

For #FluorescenceFriday - experiment was apparently a stereotaxic injection "miss", but resulted in a lovely image nevertheless. Credit to @rphillips3.bsky.social and JHU undergrad Natalia Gonzalez-Perez 🧠🔬🧪

There is a correct answer here

Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉

Check it out here: doi.org/10.1093/narg...

#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics

Clustering of spatial gene expression from a profiled tissue section of human brain in the basal forebrain

Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠

I'm there too - get in touch!

Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test

Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online

www.nature.com/articles/s41...