I feel like if homeopathy was TRYING to treat dehydration, though, it wouldn't.

We don't have cefdinir in Canada, which I must say is quite nice.

🚨 IDSA has released the first guidelines for the management and treatment of complicated urinary tract infections (cUTIs)!

The new guidelines simplify the prior definitions of uncomplicated UTIs and cUTIs, & address treatment for cUTIs.

View guidelines: bit.ly/4lUjN1a

Happy #IDPharmacistsDay to those who celebrate! (which should be everyone, amirite?😉)

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

💉 In a small RCT of IL-7 for refractory MAC lung disease, IL-7 increased lymphocyte counts but failed to convert sputum cultures.
Structural lung disease may trump immune dysfunction in driving outcomes.
journals.sagepub.com/doi/full/10....

Beyond Depression: The Role of Antidepressants in Managing Chronic Temporomandibular Disorders. A Systematic Review Background Chronic temporomandibular disorder (TMD) pain significantly impairs quality of life and lacks universally effective treatments. Antidepressants, traditionally used for mood disorders, hav.....

A bit late posting, but our systematic review on the role of #antidepressants in managing chronic temporomandibular disorder pain was published: doi.org/10.1111/joor....

Limited studies suggested benefit, particularly for agents with both noradrenergic and serotonergic activity. #TMD #pain

Staphylococcus aureus Bacteremia: A Review This narrative review summarizes current evidence on the epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment of Staphylococcus aureus bacteremia.

New review article on management of S. aureus bacteraemia: jamanetwork.com/journals/jam...

@jama.com @vancefowler.bsky.social #IDSky

Check out the gorgeous Figure which brings together elements of pathogenesis and management: (thread)

A calico cat resting casually on the back of a chair.

Realized I haven't posted my obligatory cat photo on here yet. Happy #Caturday!

TID more commonly

Picture of a plaque assay (purple field with clear holes) showing gorgeous poliovirus plaques

My replies are perpetually full of anti-vaxxers these days telling me about polio vaccines.

Not shockingly, most of what they are saying is wrong. Luckily, I trained with Vincent Racaniello & he taught me a few things about poliovirus.

So let’s discuss the king of the Picornaviridae👇🏻

Why do we use 100 mg of clofazimine in TB and NTM treatment? Abstract. Current tuberculosis and non-tuberculous mycobacterial disease guidelines recommend the use of clofazimine in a 100 mg once-daily dose. The ratio

Good question. I believe in Hanson's with ENL, the higher daily dose is used for its perceived anti-inflammatory effects. But agreed, the optimal dosing of clofazimine in general is a bit of a mystery. A nice discussion on this from earlier this year here:
doi.org/10.1093/jac/...

Agreed!

At this time, I'm not sure what types of patients this could be useful for. Small study, mostly looking at feasibility and tolerance; effectiveness metrics not captured. But interesting, nonetheless!

A loading dose of clofazimine to rapidly achieve steady-state-like concentrations in patients with nontuberculous mycobacterial disease AbstractObjectives. Clofazimine is a promising drug for the treatment of nontuberculous mycobacterial (NTM) diseases. Accumulation of clofazimine to reach

Interesting article in #JAC on loading dose of #clofazimine in nontuberculous mycobacterial disease. A 4-week loading dose of 300 mg daily resulted in faster time to steady-state-like concentrations (3.8 vs 5.3 months) and was deemed safe and well-tolerated.

doi.org/10.1093/jac/... #IDSky #NTM

Blueksy Mentions are now in Altmetric. It's been 84 years meme #AcademicSky #HigherEd #MedSky #HMSky #Altmetrics #Medlibs #Metascience

BLUESKY MEGA-THREAD

Altmetric is thrilled and also LITERALLY RELIEVED to officially announce:

We are now tracking research attention as it happens on Bluesky!

We have been picking up posts on the site since late Oct.

Our team is on Bluesky all day answering questions.

Let's get into it!

Oral cephalosporins for pyelonephritis?!
🆕️⚡️⚡️COPY-ED
Multicenter, retrospective study
N=851
No difference in 14-day pyelonephritis treatment failure for oral cephalosporins* vs FQ/TMP-SMX for outpatient pyelonephritis in the ED #idsky #medsky
* Mostly cephalexin
www.sciencedirect.com/science/arti...

I'm sure the dogma won't die that easily (do they ever?), but certainly a great step in that direction!

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...

🚨 Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections

BALANCE trial publication is here !

#IDsky #Medsky

@idjclub.bsky.social

www.nejm.org/doi/full/10....

Same here, it seems to be tolerated reasonably well. Similar to 500 mg TID, which has the same amount of clav, of course.

Action Intent Links | Bluesky Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:

docs.bsky.app/docs/advance...

#AcademicSky #HigherEd #Altmetrics

Several of us in Edmonton will do amox/clav 875 mg po TID in an attempt to strike a balance between optimizing PK/PD and patient convenience.

MYCOPLASMA PNEUMONIAE

This cheeky little intracellular bacteria seems to be up to mischief with kids in the USA at the moment

A quick thread on this bug, what's going on, and what to do (or not do!) about it

#IDSky #PedSky #PedsIDSky 🧪

1/🧵

Guidelines for the Prevention, Diagnosis, and Management of Urinary Tract Infections This consensus statement creates a clinical guideline for the diagnosis and management of urinary tract infections that addresses the gap between the evidence and recommendation strength.

My first #IDSky post will be a shameless promotion of our new UTI WikiGuideline!

jamanetwork.com/journals/jam...

Of 37 questions, only 6 had enough data to fully meet criteria for a clear recommendation!

👋 Hello friends, old and new! This move to 🦋 feels like a mass migration to a new island and I'm excited to see everyone showing up here. Enjoying the weather here so far. Looking forward to interacting and learning with and from you on this platform!