Dear all, please see link below for Milano et al, describing a role for BRCA2 (& BRCA1) in the maturation of nascent DNA strand gaps during DNA replication in the presence of PARP inhibitor. Congratulations Larissa and all !

authors.elsevier.com/a/1mtQe3vVUP...

Replicative gaps in DNA damage tolerance, genome instability, and cancer therapy Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions or difficult-to-replicate regions. This review delineates the pathways that generate, stabilize, and process these i...

Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.

#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors​​​​​​​​​​​​​​​​

www.cell.com/molecular-ce...

Our lab is hiring! Please come join our lab in the department of @UCLRespiratory in @uclmedsci.bsky.social

We have another fully funded postdoctoral position available, focusing on delineating the earliest stages of lung cancer development 🧪!

Please apply using the link below:
lnkd.in/gN4UK785

We just published a short conceptual review together with @angela-taddei.bsky.social on the spatial controls of homology search in both bacteria and eukaryotes. We discuss an emerging framework for homology search in cells with two main phases. Check it out: authors.elsevier.com/c/1mjyh,LqAZ...

Glad to have contributed to this study from @thomasmartinez.bsky.social’s lab identifying a new microprotein, NISM, implicated in nucleolar integrity! 🎉 Check out the link below:

🔗
www.biorxiv.org/content/10.6...

🥳 🎉 New preprint from the lab is out!

It's time to officially introduce the world to the Nucleolar Integrity and Stress Microprotein (NISM)!

Check out the preprint in the link below

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇
www.biorxiv.org/content/10.6...

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
1/n

Amazing work! Congrats Nibal

Happy to share the results from my PhD thesis, in which we uncovered a function for FANCD2 on maintaining fork stability upon re-replication, now out in Nat. Commun!

📖 Read the full story here: 

www.nature.com/articles/s41...

Thanks to everyone who supported me along the way!

Excited to share our new Nature study! 🧬

We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.

Full paper: www.nature.com/articles/s41...

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social .

rdcu.be/eVrxX

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...

🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics

Cohesin drives chromatin scanning during the RAD51-mediated homology search Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...

Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...

Finally published! Our work on how the #CircadianClock controls DNA repair. This has direct implications for cancer treatment: #Chronotherapy.
@CABIMER @UniSevilla

rdcu.be/eSwxl

H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death Cell Death & Disease - H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death

New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis-investigacion.bsky.social @unisevilla.bsky.social

Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks - Nature Cell Biology Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcript...

💫NEW: Saur, Lesage et al. report that RNA:DNA hybrids arise at double-strand breaks in transcribed genes, independently of de novo recruitment of RNA polymerase II/III, as a result of DSB-induced transcriptional repression.
@lablegube.bsky.social
@cbitoulouse.bsky.social
bit.ly/4kFWGr1

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...

Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...

Mitotic single-stranded DNA suppression by DDIAS Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

New work from the lab! 🔬

We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n

www.biorxiv.org/content/10.1...

Happy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

S-phase checkpoint protects from aberrant replication fork processing and degradation Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it!
Now online here 👇🏼 academic.oup.com/nar/article/...

Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity - Nature Communications Bats harbor diverse viruses but it’s less clear how they tolerate infection. Here, by characterizing innate immune responses in bat cells the authors show that IFN-beta signaling resists antagonistic ...

🚨Our new study out today in Nature Communications. Bats can asymptomatically host multiple viruses while remaining apparently healthy. Here we identify how interferon-mediated responses protect bats and identify molecular adaptations in GBP1. #LZCI
Link: www.nature.com/articles/s41...

Science Thrives on Trust: Why Collaboration Is Our Greatest Strength In a competitive academic world, building bridges instead of walls may be our most powerful tool to accelerate discovery and rebuild public trust in science.

"In a competitive academic world, building bridges instead of walls may be our most powerful tool to accelerate discovery and rebuild public trust in science."

I'm very happy with this article piece! 🥳

www.the-scientist.com/science-thri...

Shining a Light on the World of Tiny Proteins

These tiny proteins are super cool! 😊

www.science.org/doi/10.1126/...

www.nytimes.com/2025/06/12/s...

Join us NEXT WEEK for the #EMGS webinar "Oxidative DNA Damage and Repair: Impacts and Methods of Detection," featuring a workshop lead by Drs. Laurie Sanders and Tobias Dansen, a keynote talk by Dr. Karlene Cimprich, and more!

Register Today: emgs-us.org/event/OxiDNA...

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

Congrats! 🙌

Beautiful work!