Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social

Huge team effort, with immense contributions by friends from nearby and around the globe.

www.science.org/doi/10.1126/...

Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that drives programmed axon degeneration and has gathered significant interest as a therapeutic target. Despite preclinical...

In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1

- Challenges for SARM1 therapeutic inhibition

- SARM1 in non-neuronal cells

- SARM1 activation for selective peripheral neuroablation.

www.cell.com/trends/pharm...

Sir John Gurdon, 1933-2025 | Wellcome A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 October. He made a discovery that opened up the field of cloning research, and created one of the best environments for res...

A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...

It is 22 years ago today that my best friend, Nick Everton, died. He was 17 years old. Not much time to leave a mark on the world you would think.
But those of us who knew him came away irreversibly altered by even the short time we shared together....
🧵

Yes I heard about Bill. Never had the chance to meet him. I remember Kristjan & Rhona collaborated with him on the Schwann cell precursor transplantation for CNS remyelination project while I was in the lab. My condolences to you too.

It’s with a very heavy heart that I share with you the news that Prof Kristjan Jessen has passed away.

Kristjan with his wife Rhona were at the forefront of the #Schwanncell field for over 3 decades.

Kristjan was my first scientific mentor & he taught me a lot. He will be sorely missed.

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...

Congratulations @janos-groh.bsky.social ! Fantastic work!

Just finished the Peripheral Nerve Society meeting in Edinburgh #PNS2025. The last few days have been a whirlwind of science and medicine with inspiring talks and great posters in everything to do with peripheral nerve. It’s also been great to catch up with old colleagues.

I had a great experience publishing in @jcellsci.bsky.social - would highly recommend it!

😂

Sunrise over the Tyrol alps It will be alright in the end. And if it's not alright, it is not yet the end. #AcademicSky #ClimateSky #Altmetrics

THREAD

Things that didn't make the news that will likely change our lives for the better

The news is not an accurate reflection of the world.

Good news doesn't get reported as much.

Here are the wonderful things researchers have achieved recently.
1/24

This sounds completely shocking. I really hope it’s not as bad as it sounds.

This is very sad news!

Make a much shorter to-do list! 15 quick, simple ways to avoid overwhelm From weightlifting to woodland walks, Guardian readers and health experts share their tried-and-tested ways to keep burnout at bay Overwhelm can come from multiple worries going round and round in our heads like a washing machine, which can deplete our…

Make a much shorter to-do list! 15 quick, simple ways to avoid overwhelm

Thank you @frezzalab.bsky.social. I have just come across your blogs and I’ve found them very enlightening.

Yes that is really excellent! Happy New Year btw!

It’s amazing how humanity spent hundreds of years trying to eradicate disease from food/beverages and through vaccination to reduce child mortality and increase life expectancy & we are throwing it away in an instant.

Sheer madness.

Donald Trump and Elon Musk will unite British politics - against them We are primed for manipulation

The woes of the govt are overdone. Their biggest problem is a consistent tendency to favour tactics over strategy. And failing to change the law to protect British democracy from Musk's money, is the worst example of this yet. My piece for
the i.

inews.co.uk/opinion/dona...

Wishing everyone a very Merry Christmas/Happy holidays!🎄

No

Thou shalt pay Amazon workers fairly, for they are as close as it gets to being Santa’s elves. Without them, Christmas doesn’t happen.

😂😂

Wow. Nice collection but you are missing a coffee siphon!

A neurologist with 2 APOE4 copies tells us about his experience with #Alzheimers disease
washingtonpost.com/wellness/202...

Would be great to catch up. Andrea is also coming and I’m sure @colemanlab.bsky.social will be there too.

2025 PNS Call for Abstracts - Submission Deadline Extended - pnsociety.com

PNS2025 meeting for the first time will include a consortium dedicated to nerve injury & repair.

Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair

pnsociety.com/2025-pns-cal...

I’ve been meaning to buy one of these for the last couple of years!

I know it's not Friday but I just want to revisit this because look at this beautiful painting I was given by artist @ab-etc.bsky.social - the photo doesn't do it justice but it is called Thalamus Poppies (I would add a heart emoji but they don't seem to be working). Thank you Anne!