Welcome to the institute and department, Alena! 🎉

Very interesting study demonstrating the impact of improving vascular health on Alzheimer’s pathology!

📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...

Implication: Current amyloid-PET may underestimate the most damaging Aβ burden, with direct consequences for clinical trials — arguing for complementary biomarkers and new imaging strategies targeting neurotoxic amyloid conformations.

Key points:
• Peripheral immune insults phenocopy TREM2/APOE risk, impairing microglial plaque engagement
• Non-compacted amyloid, not compact plaques, best predicts neuritic dystrophy
• These toxic amyloid states are invisible to standard amyloid-PET (e.g. [¹⁸F]flutemetamol)

🧠🦠 New preprint out!

Systemic inflammation fundamentally reshapes amyloid plaques — shifting them toward non-compacted, filamentous Aβ states that strongly predict neuritic damage across mouse models and human Alzheimer’s disease.

#Alzheimers #Neuroimmunology #Microglia #Amyloid #PET #Inflammation

Important study for understanding the vascular mechanisms of dementia!

Very cool work! Glad to have been able to contribute.

Jonas Neher, Sarah Marzi, Susanne Kooistra and Renzo Mancuso at the microglia epigenetics symposium for the Glia conference 2025 in Marseille.

Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: @jonasneher.bsky.social, @kooistrasm.bsky.social, @mancusorenzo.bsky.social. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...

led by Michael Heneka, published in @natrevimmunol.bsky.social today

(MANY more authors listed and linked below)