The Netherlands #ME/CFS Cohort and Brain Biobank Consortium
Brain changes in ME/CFS:
Felipe Correa da Silva
January, 2026
Brain changes in ME/CFS: post-mortem analyses of neuro-endocrine, microglial and mitochondrial mechanisms
Brain multiregion single-cell
transcriptomics of ME/CFS
requiring extensive and costly medical care,” the researchers wrote. “Missed prevention opportunities for the children described in this report included failure to be vaccinated before the injury, delays in wound care, and lack of timely administration of TIG after exposure and before illness onset,
Missed prevention opportunities for the children described in this report included failure to be vaccinated before the injury, delays in wound care, and lack of timely administration of TIG after exposure and before illness onset, including refusal.
“Tetanus can result in serious health consequences
A new visual from wecrunchme showing how #ME/CFS creates extreme physical limitations - worse than those typically seen in patients with cancer, heart disease, or other common chronic conditions.
This uses the SF-36 measure, with results from Nacul et al. (2011) paper.
@rorpreston.bsky.social
Source and leafleat
www.oneagleswings.me.uk/wp-content/u...
www.oneagleswings.me.uk
stairs, attending a party... things they would normally have had no problem with... listen to them.
Encourage them to stop, to get in bed and rest, and to stay there except for doing necessary things that won’t exert energy.
ME, a lifelong #pwME: easier said than done…
their cells, to regroup and recover.|
A universal symptom of ME and Long Covid is Post Exertional Malaise (PEM). The body just seems to give out after exertion. If someone with mild ME or Long Covid is unusually tired at the end of a day of work, or from cleaning their home, going shopping, climbing
CRASH PREVENTION BY GALEN WARDEN From the forthcoming book, Dying to Live The most urgent thing you can do to prevent someone with Mild ME/CFS or Long Covid from becoming as severely ill as my son James, who is 100% bedrid-den, is to let them rest. Only extreme, radical rest will allow their bodies, their cells, to regroup and recover. A universal symptom of ME and Long Covid is Post Exertional Malaise (PEM). The body just seems to give out after exertion. If someone with mild ME or Long Covid is unusually tired at the end of a day of work, or from cleaning their home, going shopping, climbing stairs, attending a party... things they would normally have had no problem with... listen to them. Encourage them to stop, to get in bed and rest, and to stay there except for doing necessary things that won't exert enerov
CRASH
PREVENTION
BY GALEN WARDEN
From the forthcoming book, Dying to Live
The most urgent thing you can do to prevent someone with Mild #ME/CFS or Long Covid from becoming as severely ill as my son James, who is 100% bedrid-den, is to let them rest. Only extreme, radical rest will allow their bodies
are asked to prove their medical frailty - how sick we really are.
This #MillionsMissing, we are Frail and Furious, and we are mobilizing the community to educate the world about how serious and complex this disease truly is.
@meactnet.bsky.social
#MillionsMissing 2026 Toolkit
Governments and healthcare systems around the world fail to classify myalgic encephalomyelitis (aka #ME/CFS) as a serious, complex medical condition, leading to significant neglect in medical care and social services. Over and over again, people with ME and Long COVID
6/6
Huge thanks to everyone who helped bring this appeal to life. Please watch and share to raise awareness and understanding 🧡
Read more about Andrea, Alice & Isla, and Mark here 👇
www.actionforme.org.uk/support-us/b...
#pwME #BBCLifeline
Poster showing a video camera on a tripod with text “BBC Lifeline Appeal – Airing Sunday 26 April.” The Action for ME logo appears in the top right, and a Lifeline logo with two reaching hands is at the bottom.
1/6
🚨 ME on the BBC
We are delighted to have been selected for a BBC Lifeline Appeal - a unique opportunity to increase understanding of ME and share the voices of the ME community across national TV!
#pwME
⬇️
Update of the current demo dates #ME/CFS 🇩🇪 #pwME
Newly added:
Kassel, Münster, Nuremberg, Weimar, Schweinfurt
A final time for Oldenburg, Bielefeld, Bremen, Dresden & Tübingen
+ a final date and time for Ulm
• slight time change at Freiburg & Nordhorn/Grafschaft Bentheim
@liegenddemo.bsky.social
La liste impressionnante des actions et rassemblements organisés dans toute l'Allemagne par le collectif @liegenddemo.bsky.social autour de la journée internationale de sensibilisation à l'EM.
#MEawarnessDay #MECFS #12mai
Germany, like any other place in the world, has still a loooong way to go regarding #ME, but PHEW... what they have achieved politically, financially, medically, and socially (press included) in 4y for Long Covid / Myalgic Encephalomyelitis seems simply 'impossible' anywhere else.
Danke 🤝🙏💜
cellular energetics.
🏷️ @cgatist.bsky.social @simonmcg.bsky.social @lizworthey.bsky.social
protective, whereas increased glycoprotein acetyls and mean platelet volume increased risk. Together, these findings indicate that ME/CFS susceptibility reflects interacting pathways involving barrier–microbiome dysfunction, neurovascular instability, inflammation, platelet activation, and impaired
consistent genetic correlation but relatively low shared pleiotropy, suggesting that metabolic dysfunction may act through broader physiological networks. Mendelian randomization identified three biomarkers with evidence for causal effects on ME/CFS risk: higher mitochondrial DNA copy number was
genetic overlap with ME/CFS, with migraine and irritable bowel syndrome contributing most to shared pleiotropy. Immunothrombotic related and inflammatory traits showed smaller but measurable genetic correlations. Energetics-related traits, including type 2 diabetes and blood lactate, displayed
statistics from DecodeME (15,579 cases), we performed genetic correlation, pleiotropic heritability, and Mendelian randomization analyses. Across 22 auxiliary traits spanning five mechanistic domains, cellular energetics, neurovascular regulation, and barrier–microbiome function showed the strongest
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-acute infection syndromes (PAIS) are multisystem disorders involving immune, vascular, neuroinflammatory, and metabolic abnormalities, yet the causal relevance of these processes remains unclear. Using genome-wide summary s
New pre-print study possible thanks to @decodemestudy.bsky.social’s data
Insights into Pathophysiological Pathways in #ME/CFS Through Genetic Correlation and Mendelian Randomization
Matthias Wielscher, Leonardo Vincenzi, Wolfgang P Weninger, Eva S Schernhammer Medical University of Vienna
@unroll.skywriter.blue
Pope Leo XIV @Pontifex X.com #ArtificialIntelligence systems increasingly shape and permeate our mentality and social environments. Like every great historical transformation, this too calls not only for technical competence, but also for a humanistic formation capable of making visible the logic behind economics, embedded biases and forms of power that shape our perception of reality. 1:31 PM • 4/17/26 • 91K Views
Pope Leo XIV @Pontifex X.com Within digital environments — structured to persuade — interaction is optimized to the point of rendering a real encounter superfluous; the otherness of persons in the flesh is neutralized, and relationships are reduced to functional responses. Dear friends, you, however, are real persons! Creation itself has a body, a breath, a life to be listened to and safeguarded. 1:31 PM • 4/17/26 • 209K Views
Pope Leo XIV @Pontifex X.com When simulation becomes the norm, it weakens the human capacity for discernment. As a result, our social bonds close in upon themselves, forming self-referential circuits that no longer expose us to reality. We thus come to live within bubbles, impermeable to one another. Feeling threatened by anyone who is different, we grow unaccustomed to encounter and dialogue. In this way, polarization, conflict, fear and violence spread. What is at stake is not merely the risk of error, but a transformation in our very relationship with truth. 1:31 PM • 4/17/26 • 696K Views
Pope Leo on AI:
“Within digital environments — structured to persuade — interaction is optimized to the point of rendering a real encounter superfluous; the otherness of persons in the flesh is neutralized, and relationships are reduced to functional responses.”
This short thread is worth reading:
Even octogenarians nuns get evicted from their convent these days, after being put into a nursing home against their will…
The Netherlands #ME/CFS Cohort and Blobank Consortium
Brain changes in ME/CFS: post-mortem analyses of neuro-endocrine, microglial and mitochondrial mechanisms
Brain multiregion single-cell
transcriptomics of ME/CFS
Felipe Correa da Silva
13-01-2026
This project is made possible by: ZonMw
I'm not joking when I say mRNA technology is more important than "AI" and it's a tragedy we're throwing billions into one while our government is aggressively defunding the other.
Please refer to @mecfsscience.org ‘s 🧵 on the findings by Dr. Felipe Correa da Silva on the first 10 brain autopsies of #pwME from the Netherlands below
#ME/CFS #HPA #CRH
Also
🏷️ Prof. @cgatist.bsky.social spoke about this eye opening research just to weeks ago
youtu.be/KHxzn3VFevw?...
After reading this wikipedia entry on CRH, imagine if your brain had no CRH neurons…
Pair the reading with these www.healthrising.org/blog/2025/12...
And this www.s4me.info/threads/loss...
#ME/CFS #HPA #CRH
Paulo Coelho (b. 1947) ...