Welcome @bbbranjan.bsky.social! His career across single-cell genomics, 🐁 biology and software dev has been about bridging wet-lab with reliable analysis workflows. At @embl.org he will lead a collab with @vrmlnroel.bsky.social on modelling GxE interactions to dissect risk factors for human disease.

So there you have it, twin study estimates were greatly inflated, and molecular data sets the record straight. I walk through possible counter-arguments, but ultimately the uncomfortable truth is that genes contribute to traits much less than we always thought.

This was a lovely read. It is tempting to overlook the “language” aspect of LLMs, which both makes them extremely versatile (since a lot can be described using language) but also imposes an implicit restriction on input. Exciting times in this space ✨

A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...

Embryonic signatures of intergenerational epigenetic inheritance across paternal environment & genetic background
@jamiehackett.bsky.social et al @embl.org see transcriptome changes in offspring after fertilisation by fathers exposed to gut dysbiosis or western diet
www.embopress.org/doi/full/10....

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

This is wild. Hotelling's 1930 unpublished work (later provided by Ore) detailing differential geometric approach to describe statistical distributions used population genetics as its first example application.

Perhaps not that surprising given his communications with Fisher, but still neat!

What we talk about when we talk about risk How embryo selection exploits our flawed intuitions about risk

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

To evaluate computational models, we rely on trusted benchmark data and metrics

So what if a metrics is widely used… but plain wrong? It means that evaluations in dozens of papers are meaningless.

This has happened in single cell genomics…

(1/)

We’re growing @arcadiascience.com & are on the lookout for talent to run new pilot projects contributing to our broader goals. Seeking computational + wet lab fluency to iterate independently on new projects. If you’re a creative scientist w/ ambitious ideas, apply!

jobs.lever.co/arcadiascien...

#EMBOClimateResilience
“The way in which our universities have divided up the sciences does not reflect the ways in which nature has divided up its problems”
@embo.org
@monicabettencourt.bsky.social

Just a gentle reminder that deceptive hyping in scientific publications (which includes preprints) is actually antithetical to the core mission of the scientific process. We can stay grounded, truthful, humble while being ambitious. Revealing caveats, pitfalls & limitations speeds up progress.

Night Science Where do ideas come from? In each episode, scientists Itai Yanai and Martin Lercher explore science's creative side with a leading colleague. New episodes come out every second Monday.

I'm almost halfway through Night Science (I know, I'm so late on getting on this train). Apropos of absolutely nothing beyond their new logo, here are my top 8 favorite episodes from the first 30 installments of this gem of a podcast. @nightsciencepod.bsky.social nightscience.buzzsprout.com/1744020

Associate or Senior Editor (Computational and mathematical biology), Nature Communications - Beijing, Jersey City, Nanjing, New York, Philadelphia, Shanghai, Madrid, Milan (hybrid working) job with S... Job Title: Associate or Senior Editor (Computational and mathematical biology) Organisation: Nature Communications Location: Beijing, Jersey City, ...

We are hiring! Associate or Senior Editor in computational and mathematical biology #scijobs

US, China, Madrid, Milan
Closing date April 4th

www.nature.com/naturecareer...

Postdoctoral fellow - Saez-Rodriguez Group Your group Saez-Rodriguez Research Group Your supervisor Julio Saez-Rodriguez Your role As a postdoctoral fellow in the Saez Rodriguez group, you will develop and apply computational methods and tools...

6 days left to apply to the Post-doc opening in our lab
@ebi.embl.org to develop&apply #bioinformatics & #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data: embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

Opinion | Covid’s Deadliest Effect Took Five Years to Appear (Gift Article) What once belonged to all of us now belongs to corporations.

“Back then, the overwhelming public sentiment was: never again. Today, it seems: never what?”—Siddhartha Mukherjee
Exceptional essay
Gift link

www.nytimes.com/2025/03/10/o...

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

Let’s not lose hope that we can find our way to a better world. It might take time but we should realize that we aren’t the product of warring #SelfishGenes but the creation of #CooperativeCells
english.elpais.com/science-tech...

Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.

A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪

Why does @weare.rladies.org have less than 1000 followers? We can do better than this #rstats folks. It is a terrific account to follow because every week not only we get to know a new member of the #RLadies community but we also get to read their R favorites, tips, and jokes.

Do you have ambitious plans to study the molecular mechanisms of environmental adaptation in mammalian model systems? Join EMBL Rome as an independent group leader: generous core funding & benefits, top-level students & core facilities. embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Congratulations Sara!! 🍾🎊🥳🥂

EPFL Life Sciences Early Independent Research Scholar (ELISIR) From exceptional PhD directly to independent group leader

Fantastic opportunity: 🚀 Calling early-career scientists! Apply for the 2025 ELISIR Scholar at EPFL. From outstanding PhD straight to group leader. Join an interdisciplinary research community to conduct independent research in any area of #lifesciences in Lausanne, CH
👉 go.epfl.ch/ELISIR

🚨🚨🚨

If you're a bioinformatician who loves:

🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling

Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com

Please RT! 🙏

A great opportunity to be part of a truly unique and collaborative scientific environment 🧬☀️ Do apply!

Lovely initiative by @jamiehackett.bsky.social, thanks for the highlight 🥰

Thanks for the shoutout, Marzia :)

Some lovely news to open my Bluesky account 😇
Incredibly grateful to Mathilde, @jamiehackett.bsky.social and Ana Boskovic for the opportunity to contribute to this project 🙏
Delighted to see this out on @biorxivpreprint.bsky.social! 🎉🥂