BARI is celebrating Orion Weiner on his new review! It dives into how immune cells and tiny amoebas both build their own chemical signposts to team up from far away. Two very different cells solving the same puzzle in clever ways. cshperspectives.cshlp.org/content/earl...

Transcriptional Regulatory Modulation as a Potential Therapeutic Modality Numerous human diseases are caused by changes in gene expression levels. In addition, changing the expression levels of specific genes can lead to therapeutic benefits for several diseases. Systems us...

Big cheers for BARI’s Nadav Ahituv on this new review! It dives into clever ways scientists can dial gene activity up or down, like a smart dimmer switch, to help treat genetic conditions without rewriting the DNA code. Promising for the future of medicine! www.annualreviews.org/content/jour...

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells Aging is accompanied by significant changes to the immune system. Allen et al. demonstrate that age-related NF-κB activation in fibroblasts remodels the lung resident immune system and promotes the em...

www.cell.com/immunity/ful...

Congrats to BARI’s Tien Peng on his new paper! It shows how aging fibroblasts in the lung starts a chain reaction of chronic inflammation and overactive immune cells, helping us understand why older folks are more at risk for serious lung issues. Hopeful step toward better aging!

Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions Brain development relies on coordinated remodeling of neuronal and glial membranes. Theisen et al. show that lysosomal breakdown of lipids sculpts brain architecture, as glia phagocytose neuronal memb...

BARI is celebrating John Vaughen’s new Neuron study! It shows developing glia phagocytose neuronal membranes, salvage the lipids in lysosomes, and turn them into CPE lipids needed for autophagy and synaptic ramification. Fantastic work! www.cell.com/neuron/fullt...

BARI is celebrating Yin Shen’s new Nature Comms study! It shows how the brain cleverly compensates when enhancers are deleted on one SIN3A allele by boosting the other, precise dosage control that could matter a lot for healthy brain aging. www.nature.com/articles/s41...

A transcription regulator atlas identifies TOX3 as an Atoh1 coactivator in cerebellar development and tumorigenesis | PNAS Organ development and function are orchestrated by intricate transcriptional circuits. Here, we present a comprehensive atlas profiling 1,904 trans...

www.pnas.org/doi/10.1073/...

BARI is celebrating Guo Huang’s new PNAS study! It shows how TOX3 supercharges Atoh1 to keep cerebellar progenitors thriving during development and plays a big role in medulloblastoma too. Elegant work on brain growth and disease!

BARI’s celebrating Peggy Cawthon’s new Age and Ageing study! It shows advanced imaging features from CT scans capture skeletal muscle details that strongly tie to physical performance in older men, helping us fight sarcopenia and keep mobility high with aging. bit.ly/3OqwN3u

BARI’s cheering for Saul Villeda! His research just got spotlighted in The Washington Post! It shows exercise strengthens the blood-brain barrier in Alzheimer's models, leading to better memory and learning. Read it here: www.washingtonpost.com/wellness/202...

Alanine catabolism as a targetable vulnerability for MYC-driven liver cancer Montoya et al. uncover a role for alanine as a conserved metabolic substrate for MYC-driven liver cancer. GPT2 is a therapeutic target for MYC-overexpressing liver tumors.

www.cell.com/cell-reports...

BARI's celebrating Dr. Andrei Goga's new Cell Reports study! It shows MYC-driven liver tumors depend on breaking down alanine for energy and survival, and targeting this pathway (with a drug or genetics) really slows them down. Meaningful step forward for age-related cancer research.

BARI’s been busy! If you’re into aging research, swing by our Updated News page for the newest publications and discoveries from our labs. Super proud of our members and would love for you to check it out and join the conversation.
geroscience.ucsf.edu/updated-news

The Role of Fat in Osteoarthritis Our work challenges the traditional view of osteoarthritis (OA) as a wear-and-tear disease of aging, proposing a paradigm shift toward understanding OA as a systemic condition influenced by metabolic...

onlinelibrary.wiley.com/doi/epdf/10....

Check out BARI’s Kelsey Collins excellent review in JOR. It reveals how fat is a key driver of osteoarthritis through metabolic and immune signals, linking directly to age-related joint decline. This could transform how we approach healthy aging and pain management. Fantastic work Kelsey!

The Hsp40 cochaperone DNAJC7 regulates polyglutamine aggregation and exhibits context-dependent effects on polyglycine aggregation Protein-encoding nucleotide repeat expansion diseases, including polyglutamine (polyQ) and polyglycine (polyG) diseases, are characterized by the accumulation of aggregation-prone proteins. In the pol...

Cheers for BARI's Martin Kampmann on his new JBC paper! It uncovers how DNAJC7 fights polyQ aggregation in Huntington's-like diseases and tweaks polyG, connected to aging, where protein clumping drives neurodegeneration. Read more here: www.jbc.org/article/S002...

Magnetic Resonance Imaging Abnormalities and Incidental Age-Related Changes In this issue of JAMA Internal Medicine, the Finnish Imaging of Shoulder Study (FIMAGE) study1 offers timely and clinically important evidence regarding what clinicians and patients read in shoulder m...

Big congrats to BARI's Dr. Brian Feeley on his JAMA Internal Medicine article! It breaks down how most shoulder MRI "issues" are just normal aging wear-and-tear, even in pain-free folks—super relevant to aging biology for smarter care and avoiding extra surgeries. jamanetwork.com/journals/jam...

onlinelibrary.wiley.com/doi/10.1111/...

Big cheers for BARI's Dr. Diane Barber on her Acta Physiologica review about lysosome pH in health & disease! It connects the dots on how pH shifts affect lysosomal roles: super relevant to aging, where off-balance pH worsens neurodegeneration and protein buildup. Exciting therapeutic angles!

She shared how OA surrogate markers revolutionized trials—let's do the same for aging, while zeroing in on real patient wins: no disability, dementia, or death.

BARI's Peggy Cawthon at the ICFSR conference on healthy longevity & aging biomarkers: Hosted by Nature Aging's Sébastien Thuault, with Luigi Ferrucci, David Furman, & Dan Belsky.

Vitamin B2 and B3 nutrigenomics reveals a therapy for NAXD disease A nutrigenomics framework identifies genetic diseases amenable to vitamin B2 and B3 therapies. This approach nominates vitamin B3 as a therapy for NAXD deficiency, a lethal neurodevelopmental disorder...

www.cell.com/cell/fulltex...

Big cheers for BARI member Isha Jain on her new Cell paper! It reveals how vitamins B2 and B3 can treat NAXD disease, saving metabolism, shielding the brain, and stretching lifespan over 40x in models. Ties right into aging biology, where boosting NAD could slow down age-related breakdowns.

Kelsey H. Collins, PhD, Wins NEXT Award for Translational Research on Relationship between Fat and Osteoarthritis Development and Pain /PRNewswire/ -- The 2026 New Emerging eXperts in Translational Science (NEXT) Award was granted to Kelsey H. Collins, PhD, for her research on the role of fat...

BARI is celebrating today! Kelsey Collins just won the 2026 NEXT Award for her research on the surprising role of fat in osteoarthritis and joint pain.
Turning personal inspiration into real mechanistic discoveries – this is why we do what we do. Congratulations, Kelsey! bit.ly/4sCUdBd

Non-visual light modulates behavioral memory and gene expression in Caenorhabditis elegans Visible light engages a non-visual, bZIP-dependent transcriptional pathway in peripheral tissues that communicates with the nervous system to shape behavioral plasticity and memory, enabling optogenet...

BARI’s Dengke Ma shows non-visual light tweaks genes & improves adaptability in worms in a bacteria-dependent, wavelength-sensitive pathway. Enhances olfactory memory & potential for aging sensory research. Check it out: elifesciences.org/articles/108...

Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude High-altitude conditions improve glucose tolerance and reduce diabetes risk, but the physiological mechanism is not well understood. Using mouse model…

Isha Jain at BARI just published this in Cell Metabolism: Living high up makes blood sugar drop because red blood cells soak up glucose in low oxygen. Hypoxia can even treat diabetes in mice! #metabolism www.sciencedirect.com/science/arti...

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration - Nature Reviews Drug Discovery Neuroimmune interactions shape neurodegenerative disease progression. This Review examines how microglia integrate signals from central and peripheral immune cells, outlines emerging therapeutic targe...

BARI’s Andrew Yang breaks down how immune cells in the brain fuel neurodegeneration and what we can target to stop it. From microglial states to complement and inflammasomes, this review maps therapies that could help aging brains stay sharp longer. go.nature.com/4096fGg
#aging #neuroscience

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...

www.cell.com/cell/fulltex...

New out in Cell! Bari’s Saul Villeda shows how a liver factor from exercise (GPLD1) rejuvenates brain barriers, clears AD gunk, and boosts memory in old mice. By hitting specific vessel proteins, it mimics workout perks. Promising for fighting dementia! #aging #neuroscience

Modulation of the 14-3-3σ/C-RAF "Auto"inhibited Complex by Molecular Glues - PubMed Molecular glues, compounds that bind cooperatively at protein-protein interfaces (PPIs), are revolutionizing chemical biology and drug discovery, allowing the modulation of traditional "undruggable" targets. Here, we focus on a native regulatory PPI between the scaffolding protein 14-3-3 and C-RAF, …

pubmed.ncbi.nlm.nih.gov/41617210/