A couple who created the first approved gene therapy for blindness awarded $3m (£2.2m) Breakthrough Prize for Life Sciences.
Molecular biologist Jean Bennett & ophthalmologist Albert Maguire share the prize with physician Katherine High.
🧪👁️
www.theguardian.com/science/2026...
With the new changes, a B on an #ERC application may actively make you less employable. People looking for postdocs will prioritise hires who might get funding over those that are banned from even applying.
#academicchatter
Be Patient ❣️
Cloud of words in various colors and sizes on a black background, arranged in the shape of a circle. Some of the largest words include cell dendritic infection response th2 induction helminth inflammation macrophage role type vivo activation human mansoni production schistosoma development lung CD4 function immune macrophages airway microbiota th1 cd11c differentiation expression gut
Cloud of words in various colors and sizes on a black background, arranged in the shape of a rectangle. Some of the largest words include Cell Dendritic Infection Response Th2 Induction Helminth Inflammation Macrophage Role Type Vivo Activation Human Mansoni Production Schistosoma Development Lung Cd4 Function Immune Macrophages Airway Microbiota Th1 Cd11c Differentiation Expression Gut
Cloud of words in various colors and sizes on a black background, arranged in the shape of a rectangle. Some of the largest words include Cell Dendritic Infection Response Th2 Induction Helminth Inflammation Macrophage Role Type Vivo Activation Human Mansoni Production Schistosoma Development Lung Cd4 Function Immune Macrophages Airway Microbiota Th1 Cd11c Differentiation Expression Gut
Fresh batch of Scholar Goggler clouds for Andrew S. MacDonald. Hot topics: cell, dendritic, infection, response, th2, induction @profandrewmac.bsky.social
Create yours at https://scholargoggler.com/
#AcademicSky #CellBiology #Immunology
Sunrise over water
A very pretty sunrise this morning to start the day ☀️
A picture of a woman running and labels put in front of it like a typical online video narrating the scene. They read: Nobody sees the 4am workouts. Nobody sees me meal prepping for hours every week. Nobody sees any of this. Because I don't do those things.
lol 😂
Atlantic beach
New preprint describes “a spectrolaminar organization of neurovascular coupling in the human auditory cortex” to distinguish feedforward vs feedback dynamics across cortical depths.
A good first step.
The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.
How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!
Out today in Nature: rdcu.be/fdC2A
@uclbrainscience.bsky.social
If you're interested in the intersection of neuroscience 🧠 and software engineering 👩💻, these are excellent opportunities. Great teams and a supportive working environment.
Can't recommend them enough! #neuroskyence
Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
International Women’s Day
Happy International Women’s Day.
In solidarity with women in all their diversity, including women of color, queer, intersex, and trans women — and the ongoing struggle for their dignity and equality.
Celebrate #InternationalWomensDay by following diverse voices from kickass Scientists in the #zebrafish community! 💪 🐟 🧪
#WomenInScience Volume 1: go.bsky.app/4BegEjv
Volume 2: go.bsky.app/VoebYrt
For #InternationalWomensDay I’m sharing my ongoing series of women in science through history. I’m now at 79.
Here’s to the day a scientist’s sex is no longer remarkable in any field.
Since last year I have added these 12 #linocut prints.
🧪🐡👩🔬🧮🔭🎢🔬
March issue @brain1878.bsky.social with winning article in Brain Essay Competition by @oharealex.bsky.social considers if it is technologically feasible for machines to achieve human-level intelligence, and philosophically plausible for them to possess consciousness
academic.oup.com/brain/articl...
A detailed digital composite image based on the 1947 historical photograph of geneticist Barbara McClintock. McClintock, with her characteristic short hair and round glasses, is seated at a microscope, using tweezers in a Petri dish. While based on the original photo distributed for her AAUW award, this image presents a significantly expanded and fictionalized laboratory environment. The simple wooden workbench is now densely populated with a vast, colorized collection of complex glassware, numerous amber-colored reagent bottles, intricate distillation columns, and botanical specimens relevant to maize cytogenetics, creating a rich, illustrative narrative of her "jumping gene" research context that was not present in the original photo. The expanded background shows complex vintage laboratory cabinetry. This image explicitly states it is a composite: a digital recreation where Seriously Scientific has taken the historical figure and placed them into an augmented, complex fictionalized environment. Based on original source from Smithsonian Institution Archives. Digital composite by Seriously Scientific.
Remembering Barbara McClintock on International Women's Day!
She discovered that genes aren't static, they can actually "jump" around on a chromosome.
Her discovery of transposons ("jumping genes") fundamentally changed how we understand evolution and the complexity of DNA! 🧬🌽
#WomenInScience
Happy International Women's Day to all who celebrate! Rights. Justice. Action. For ALL women and girls.✊🏿
Xiaobo Wu, Laura Beth Payne & Robert G. Gourdie from @virginiatech.bsky.social offer #homocellular and #heterocellular perspectives of gap junctional and ephaptic coupling in cardiac electrical propagation 🔎 🫀
🔗📜 Read their review: physoc.onlinelibrary.wiley.com/doi/10.1113/...
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...
Hot meeting alert!! 🚨🚨 @vai.org is hosting Rising Stars and Horizons in Metabolism, a new format, 2 day symposium highlighting both established and up and coming leaders in Metabolic research. Check it out and register here: www.vai.org/event/rising...
Interested in pain and alcohol use?
If so, then a @painresforum.bsky.social webinar happening next Tuesday, 16:00 UK time is for you 👇
NetSci Satellite: Networks in Biology and Medicine (NetBioMed)
Submission deadline: March 3
#NetSci2026 #NetBioMed2026 #Biomedicine #Epigenomics #SystemsBiology #NetworkMedicine #PrecisionMedicine ./6
www.complexitycat.org/posts/netsci...
📣 We are looking for new colleagues 🔬🧬🧪
The @lmcb-ucl.bsky.social at University College London @ucllifesciences.bsky.social are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.
For anyone interested in ex–vivo brain slice electrophysiology, this pub review highlights how precisely sectioned tissues were used to reveal physiological vulnerabilities in rare disease models 🧪
🔬 Call for Papers: Channelopathies in Focus
Focusing on #ionchannel–related diseases, from classical plasma‑membrane #channelopathies to emerging roles of organellar channels, non‑excitable cell physiology, and channel‑dependent #signalling.
📍 🔗 physoc.onlinelibrary.wiley.com/hub/journal/...
McGuinness, Shen, Khalili-Araghi, Weber et al. reveal the role of #claudin-15 D55 residue in ion size & charge selectivity. A reduced model of claudin-15 offers novel insights into ion conductance, providing a valuable tool for therapeutic modulation of #TightJunctions rupress.org/jgp/article/...
It gets weirder
Check out our recently updated calendar, featuring the top neuroscience meetings and events through September 2027.
#neuroskyence #neuroscience #events
www.thetransmitter.org/events/?utm_...
