In @jgp.org, McGuinness, Weber et al. reveal the role of #claudin-15 D55 residue in ion size & charge selectivity. A reduced model of claudin-15 offers novel insights into ion conductance, providing a valuable tool for therapeutic modulation of #TightJunctions rupress.org/jgp/article/...
McGuinness, Shen, Khalili-Araghi, Weber et al. reveal the role of #claudin-15 D55 residue in ion size & charge selectivity. A reduced model of claudin-15 offers novel insights into ion conductance, providing a valuable tool for therapeutic modulation of #TightJunctions rupress.org/jgp/article/...
The various pathways that may be involved in the transmission of SARS-CoV-2 to the brain and neuroinfection in COVID-19. The spike protein on the SARS-CoV-2 S protein binds with ACE2 on the cell surface, is cleaved by the enzyme TMPRSS2, and aids the virion entry. SARS-CoV-2 infection causes immune cell infiltration that facilitates inflammatory cytokine storms and multiple-organ failure through acute respiratory distress syndrome.
The neurovascular unit in the brain. The neurovascular unit consists of vascular cells, glial cells, and neurons, including astrocytes, microglia, pericytes, and endothelial cells. The neurovascular unit controls the integrity of the blood-brain barrier (BBB). The BBB is a dynamic complex that consists of endothelia, astrocytes/astrocytic endfeet, pericytes, and tight junction components: claudins, cytoplasmic zonula occludens (ZO-1, ZO-2, ZO-3), occludins, junction adhesion molecules JAM-A, JAM-B, JAM-C), and adherens junction structures in the brain. The BBB controls nutritive substances to the brain, neurotransmitter levels, and entry of macromolecules, and it protects the brain from the entry of neurotoxins. Adherens junctions include the cadherin-catenin complex and its associated proteins.
Figure 3. SARS-CoV-2 neuroinfection-associated molecular disruption of the neurovascular unit in COVID-19/long COVID. The neurovascular unit/blood-brain barrier (BBB) is composed of endothelial cells, astrocytes, pericytes, and neurons. The tight junction and adherens junction complex between endothelial cells controls BBB permeability and the transport of substances. The BBB preciously regulates the movement of nutrients and metabolites into the brain parenchyma and prevents the entry of toxic substances. Disruption or damage of BBB is associated with various neurologic disorders through increased permeability and inflammatory cell infiltration. COVID-19 and long COVID are associated with a derangement or decrease of the tight junction and adherens junctional complex, indicating BBB disruption and leading to neuroinflammatory responses and subsequent brain pathology.
Potential Markers That May Be Associated with COVID-19, Long COVID, and Post-COVID-19 Syndrome.
#Neurosky #NeuroCovid Recap : #COVID19 & #LongCOVID: Disruption of the Neurovascular Unit, #BloodBrainBarrier, and #TightJunctions
www.researchgate.net/profile/Theo...
The images show a series of midplane cross-sections of small, spherical structures called cysts, made up of cells from a type called MDCK-II. These cysts have been genetically modified, with specific changes to their tight junctions (TJs), which are structures that help cells stick together and regulate flow between them.
How do cells control the lumen shape and size? Check out our combined work from the
Honigmann_Lab
and
RivelineLab
where we look at the mechanical role of #TightJunctions in #lumen formation: www.sciencedirect.com/science/arti...
#MedSky🧪#IDsky #COVID19 and #LongCOVID #NeuroCovid : Disruption of the Neurovascular Unit, #BBB & #TightJunctions
www.nature.com/articles/d41...
Join our Cellular Imaging lab! Offering a master position in #nano-#physiology of #tightjunctions Check out for more information and apply here👇
https://www.leibniz-fmp.de/cellular-imaging
#microscopy #jobs #masterthesis
