Imaging spotlight: Calibrating expansion microscopy to map receptor sorting domains in endosomes - FocalPlane Imaging spotlight: Calibrating expansion microscopy to map receptor sorting domains in endosomes - News

🔬🔦In their Imaging spotlight, @taylashakespeare.bsky.social and @ijayas.bsky.social highlight their research dissecting receptor sorting in endosomes using the calibrated 3D ExM toolkit that they developed.
focalplane.biologists.com/2026/04/15/i...

Imaging spotlight: Calibrating expansion microscopy to map receptor sorting domains in endosomes - FocalPlane Imaging spotlight: Calibrating expansion microscopy to map receptor sorting domains in endosomes - News

Now you can check out our paper highlights in our @focalplane.bsky.social blog post!

We demonstrate the use of a calibrated ExM toolkit to visualise complex nanodomain architectures at membrane-bound organelles in the cell ▫️➡️ ⬜ 🔬

focalplane.biologists.com/2026/04/15/i...

So exciting to see all our hard work published in ACS nano! This paper highlights how we calibrated intrinsic expansion in X10 ExM to investigate the organisation of endosomal nanodomains during EGFR trafficking - check it out! 🔨🔬📄🎉

Nanosize rulers help correct distortion in inflated cells Nanosize rulers and computer analysis help fix uneven inflation of organelles

Delighted to see our recent work on the use of self-assembling nanoscale calibrants for detecting errors in #ExpansionMicroscopy, particularly in visualising the biology of small organelles such as endosomes, featured in C&EN.

cen.acs.org/analytical-c...