⚠ @kidneyint.bsky.social January issue is out!

Read the latest news in research, highlights from current literature, comprehensive reviews, and in-depth case studies www.kidney-internati...

Read the editor's pick for this month:

Most likely CYC as Rituximab has not done so hot in SLE. However, more info on the patient will be helpful: age? Comorbidities? Baseline and peak creatinine? and some data from the biopsy: percent crescents, type of crescent (fibros, cellular, or fibro cellular) and %IFTA

A randomized controlled trial evaluated the efficacy and safety of #apixaban for prevention of recurrent thrombosis after #thrombectomy of #hemodialysis #vascularaccess

doi.org/10.1016/j.kint.2024.10.023

#MedSky #NephSky #SkyNeph

TINU?

Young patient with acute kidney injury and the biopsy findings below. Recently saw othpthamology for eye redness, pain. Glucosuria is noted. Urine beta microglobulin is elevated. Differential diagnosis? #renalpath #nephrology #pathsky #nephsky

Such an outstanding thread demystifying "drink 8 glasses of water a day" recommendation! In my personal experience, whenever I tell people that the majority of people need to drink only when they are thirsty they look at me like I am coming from a different planet!

Makes me happy when the nephrologist nails the biopsy diagnosis in their provided clinical note. Older pt with progressive CKD with minimal proteinuria, unremarkable work up. Concerned for LECT2 amyloidosis. Just have H&E this morning; but looks like they nailed it. #renalpath #pathtsky #nephrology

Systemic steroids can definitely cover all of these potential etiologies (IBD, TNF or even AIN). However, with more targted treatments available (like targeted release budesonide) coming up with clinical criteria to make the precise diagnosis will become more and more important

@jzrenlapath.bsky.social are there any histological features to help distinguish IgAN associated with tnf-i from those associated with IBD itself? The distinction can have huge implications in terms of treating IBD.

CKD, proteinuria, Crohn's disease. KBx w/focally granulomatous tubulointerstitial nephritis and IgAN. Common findings in IBD patients (pubmed.ncbi.nlm.nih.gov/38344742/). Pt on TNFa inhibitor (pubmed.ncbi.nlm.nih.gov/36706240/) also reported IgAN/TIN associations. #renalpath #pathsky #nephrology.

For all new and old: REGISTER to our first ever, recurrent FSGS only, conference! Washington DC, December 9th. We just upsized the venue to accommodate more people! Unique participation of patients, scientists, public figures and more.
Social dinner the night before for all!
#rFSGS #Nephsky #Medsky

The biggest issue (and the reason for failure) was that it was actually not approved in pre-dialysis patients (and as far as I remember, not even for PD patients) to begin with...

Looks like amyloid deposition. Beside full work up for dysproteinemia, I would do a Congo red on the tissue.