Wellcome Connecting Science Target Validation - In the Era of Genomics, Big Data, and AI (hybrid conference) Conference dates: 21-23 September 2026 Location: Hinxton Hall Conference Centre, Wellcome Genome Campus, UK and online. Bursary deadline: 22 June Abstract deadline: 13 July In-person registration deadline: 1 September Virtual registration deadline: 14 September

What's new in the era of genomics, big data, and AI?🧬

Share your insights at our Target Validation conference.
🗓️ 21–23 September | 📍 Wellcome Genome Campus, UK

Abstract deadline: 13 July 📩
Bursary support available!

👉 bit.ly/4aBLEiy
#TargetValidation #AIInDrugDiscovery #PrecisionMedicine

How I went from Oracle to Postgres (with a big NoSQL detour) with Gwen Shapira (E38) #TalkingPostgres talkingpostgres.com/episodes/how...

Now out in @acs.org JACS Au, the manuscript by #BarbaraTerlouw et al. describing PARAS, a high-accuracy machine-learning algorithm to predict substrate specificities of nonribosomal peptide synthetase (NRPS) adenylation domains, key for estimating natural product structures from BGC sequence. 1/n

New preprint @cxqiu.bsky.social @jshendure.bsky.social ! Can we learn regulatory grammars of human cell types — by training on mouse development and transferring across 241 mammalian genomes? Introducing STEAM & a whole-organism scATAC-seq atlas from E10 to birth.
www.biorxiv.org/content/10.6...

How can we see where genes are active in tissues?

The Spatial Transcriptomics Portal combines imaging and molecular data to map gene activity in spatial context.

Explore how cells interact and develop.
www.ebi.ac.uk/about/news/u...
@bioimagearchive.bsky.social @expressionatlas.bsky.social

Feel free to ask me about society publishing, publish-and-read deals, pitch a paper for MGen, maybe even for our Microbial Eukaryote genome collection... maybe for a taster, take a look at all the cool stuff already in there! 2/2 www.microbiologyresearch.org/content/micr...

Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy - Nature Cell Biology Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of autophagy and uncovers new regulatory...

☕Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of #autophagy and uncovers new regulatory pathways.
bit.ly/4sfZa2g

If you're wondering about the phases, here's our phased transition strategy enabling you to move over your MkDocs projects to Zensical:
zensical.org/compatibilit...

Release News: V96 of #Reactome is live! 🎉

We have new and updated topics and pathways in Developmental biology, Disease, Immune system, Metabolism, Muscle Contraction, and more.

💡 Read more about V96 here :https://reactome.org/about/news/291-v96-released

Dual cytosine modification through hydroxylation and arabinofuranosylation in phages - Nature Chemical Biology He et al. identified a cytosine hypermodification pathway in phage HY126. This pathway involves prereplicative deoxycytidine monophosphate hydroxylation and arabinofuranosylation, followed by postrepl...

A new paper reports a cytosine hypermodification pathway in phage HY126 that confers nuclease resistance

www.nature.com/articles/s41...

Glad to share our new work: RitS (Right into the Saddle): a generative model for direct transition state (TS) prediction.
📄 Paper: chemrxiv.org/doi/full/10.26…
🤠 Code: github.com/isayevlab/RitS
• Flow-matching model with explicit stereochemistry control
• Direct TS generation from SMILEs #compchem

Designing Protein Binders Using the Generative Model Proteina-Complexa | NVIDIA Technical Blog Developing new protein-based therapies and catalysts involves the challenging task of designing protein binders, or proteins that bind to a target protein or small molecule. The search space for…

Worth sharing. Powerful.
Please share. #AIForHumanity

developer.nvidia.com/blog/designi...

Coupling between sterol and sphingolipid structure in ordered membrane domains www.biorxiv.org/content/10.64898/2026.04...

HPV Vaccination and the Risk of Invasive Cervical Cancer | NEJM The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between qua...

There are over 200 HPV strains
40 are sexually transmitted and infect the genitalia and oral cavity.
12 are considered high-risk for cancer
Of these, HPV 16 and HPV 18 are responsible for most cancers
Don’t believe me, believe this massive study, not the ACIP.
Make sure your children are vaccinated!

Continuous abundant viral antigen drives expansion and clonal deletion (attrition) of high-affinity antiviral B cells, while low-affinity B cells are sustained. Attrition is B cell-intrinsic but is mitigated by exogenous antibody @pnas.org @unibas.ch
www.pnas.org/doi/10.1073/...

Bilbo being tempted to keep the one ring meme, with top panel saying "Impact Factor 15.9"

Reminder that you can get up-to-date curated data, including gene names, #GO annotations, #phenotypes, #PTMs, #disease, #interactions, biochemical #pathways, #regulation, #complexes, etc. from SGD Downloads. Updated weekly. Get your data and get to work: sgd-archive.yeastgenome.org/curation/lit...

The quest to understand where atoms end Atomic size measurements like van der Waals and covalent radii are central to chemistry, but are they grounded in reality?

Chemists use atomic radius as a measure of the size of an atom, typically defined as half the distance between the nuclei of two adjacent atoms.

However, in reality atoms don’t have fixed boundaries, @philipcball.bsky.social reports.

www.chemistryworld.com/news/the-que...

This is my favorite climate change chart. Japanese monks, aristocrats, and emperors kept meticulous records of cherry blossom festivals for 1,200 years and accidentally built the world's longest climate dataset.

‘Truly spectacular’ drug for sleeping sickness simplifies treatment, raising hopes for eradication European regulators greenlight new one-dose compound that could help African countries get rid of an ancient burden

This is fantastic!!
www.science.org/content/arti...

Lab Leakers: "SARS-CoV-2 can't infect bats, so it must have been made in a lab".

Science: "Let's do the experiment".

SARS-CoV-2 behaves exactly like one would expect in a reservoir species - low-level infection, no overt disease, etc.

Elegant study from Sato Lab:
www.biorxiv.org/content/10.6...

Release 2026_03_1 (Q1 2026) Release · rdkit/rdkit Release_2026.03.1 (Changes relative to Release_2025.09.1) Acknowledgements (Note: I'm no longer attempting to manually curate names. If you would like to see your contribution acknowledged with you...

We did a new major #RDKit release yesterday. v2026.03.1 is out and the conda-forge builds are available.

As always, especially with major releases, be sure to read the "Backwards incompatible changes" section of the release notes!

github.com/rdkit/rdkit/...

Review @cp-cellreports.bsky.social
The maternal-fetal interface as an immunological barrier: Structure, regulation, and breakdown
www.cell.com/cell-reports...

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

Wow, you rock! Thanks so much.

Structural basis for prostaglandin and drug transport via SLCO2A1 Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...

Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work!

@oxfordbiochemistry.bsky.social

www.nature.com/articles/s41...

Great thanks!.

Congrats and thanks for putting this together! Any timeframe for publication of vol 728? Best -- f

Oh this is great! Glad I asked. Will wait also for the lower confidence set to explore in more detail. Thanks!!!

Pharmaceutical companies move away from horseshoe crab biomedical testing Amgen and Abbott are ditching horseshoe crab blood for synthetic alternatives — a win for a 450-million-year-old species edging toward extinction.

"One of the biggest drivers...unsustainable harvest for their blood to be used in pharmaceuticals. Now, two major pharmaceutical companies, Amgen Inc. and Abbott Laboratories, have publicly announced they will shift toward synthetic blood instead."

news.mongabay.com/short-articl...